Results 101 to 110 of about 127,911,481 (277)

Design and simulation of a novel MEMS based microfluidic circulating tumor cell (CTC) detection system for a lab on a chip device

IOP Conference Series: Materials Science and Engineering, 2020
This paper proposes a novel microfluidic system for a lab on a chip device which includes three major systems: a microchannel, micromixer and a droplet generator.
M. P. Suriyage, P. V. K. Asanka, T. Cooray, D. L. F. M. Liyanage, R. A. N. I. Pushpakumara, D. K. Hendavitharana, W. W. A. T. I. Fernando, W. H. P. Sampath, Y. Amarasinghe   +8 more
semanticscholar   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Microfluidics-Based Technologies for the Assessment of Castration-Resistant Prostate Cancer

Cells
Castration-resistant prostate cancer remains a significant clinical challenge, wherein patients display no response to existing hormone therapies. The standard of care often includes aggressive treatment options using chemotherapy, radiation therapy and ...
Amel Sassi, Lidan You
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Host-microbe-cancer interactions on-a-chip

Frontiers in Bioengineering and Biotechnology
The tumor microbiota has emerged as a pivotal contributor to a variety of cancers, impacting disease development, progression, and therapeutic resistance.
Mauricio G. C. Sousa, Mauricio G. C. Sousa, Mauricio G. C. Sousa, Danielle S. K. Brasino, Madeline Krieger, Duygu A. Dindar, Rebekka Duhen, Rebekka Duhen, Zhenzhen Zhang, Cristiane Miranda Franca, Cristiane Miranda Franca, Cristiane Miranda Franca, Luiz E. Bertassoni, Luiz E. Bertassoni, Luiz E. Bertassoni, Luiz E. Bertassoni, Luiz E. Bertassoni   +16 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications

, 2020
Polydimethylsiloxane (PDMS) is among the most widely used materials for organ-on-chip systems. Despite itsmultiple beneficial characteristics from an engineering point of view, there is a concern about the effect of PDMSon the cells cultured in such ...
Carter, Sarah-Sophia,, Kadekar, Sandeep,, Atif, Abdul Raouf,, Varghese, Oommen P., Mestres, Gemma,, Carter, Sarah-Sophia, Tenje, Maria,, Engqvist, Håkan, Varghese, Oommen P.,, Tenje, Maria, Kadekar, Sandeep, Engqvist, Håkan,, Atif, Abdul Raouf, Lanekoff, Ingela, Lanekoff, Ingela,, Mestres, Gemma   +15 more
core   +1 more source

Engineering the tumor microenvironment of colorectal cancer [PDF]

, 2014
The tumor microenvironment contributes significantly to the clinical prognosis, especially in CRC. Infiltration by cells from the adaptive immune system (e.g. CD8) has been linked to a better survival independently of TNM-stage.
Hirt, Christian Kurt
core   +1 more source