Results 51 to 60 of about 91,694,512 (315)

Scalability of Network-on-Chip communication architecture for 3-D meshes. [PDF]

, 2009
Design constraints imposed by global interconnect delays as well as limitations in integration of disparate technologies make 3D chip stacks an enticing technology solution for massively integrated electronic systems.
Awet Yemane Weldezion, Tenhunen, Hannu, Matt Grange, Roshan Weerasekera, Grange, M, Jantsch, A, Weldezion, Awet Yemane,, Pamunuwa, Dinesh Bandara, Jantsch, A., Zhonghai Lu, Lu, Zhonghai, Pamunuwa, Dinesh, Dinesh Pamunuwa, Pamunuwa, I D B, Axel Jantsch, Weldezion, A., Weldezion, A. Y., Jantsch, Axel,, Tenhunen, Hannu,, Weerasekera, Roshan, Hannu Tenhunen, Tenhunen, H, Grange, M., Lu, Zhonghai,, Weerasekera, R., Grange, Matt   +25 more
core   +1 more source

A microvessel-on-a-chip for studying how tumor-derived factors prime the endothelium for extravasation

, 2023
Slater, John H.Metastasis is a leading cause of disability and death from cancer. Each year, 50% of new cancer patients are diagnosed with metastasis and must undergo immediate and aggressive treatment.
Sperduto, John Lewis
core   +1 more source

An in vitro model of cancer invasion with heterogeneous ECM created with droplet microfluidics

Frontiers in Bioengineering and Biotechnology, 2023
Metastasis is a multi-step process that is critically affected by cues from the tumor micro-environment (TME), such as from the extracellular matrix (ECM). The role of the ECM in the onset of metastasis, invasion, is not yet fully understood.
Mohammad Jouybar, Mohammad Jouybar, Jelle J. F. Sleeboom, Jelle J. F. Sleeboom, Jelle J. F. Sleeboom, Elnaz Vaezzadeh, Cecilia M. Sahlgren, Cecilia M. Sahlgren, Cecilia M. Sahlgren, Jaap M. J. den Toonder, Jaap M. J. den Toonder   +10 more
doaj   +1 more source

Gradient-sized control of tumor spheroids on a single chip.

, 2020
Multicellular tumor spheroids are attracting more attention as a physiologically relevant in vitro tumor model for biomedical research. The size of spheroids is one of the critical parameters related to drug penetration and cellular responses. It remains
Gallego-Ortega, D, Jin, D, Law, A, Fang, G, Lin, G, Lu, H   +5 more
core   +1 more source

Integrating biological vasculature into a multi-organ-chip microsystem

, 2022
S.3588-3598A chip-based system mimicking the transport function of the human cardiovascular system has been established at minute but standardized microsystem scale.
Lindner, G., Sonntag, F., Menzel, U., Marx, U., Groth, B., Horland, R., Lauster, R., Hoffmann, S., Walles, Heike, Lorenz, A., Schimek, K., Busek, M., Brincker, S.   +12 more
core   +1 more source

Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches

Disease Models & Mechanisms, 2018
Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process.
Jelle J. F. Sleeboom, Hossein Eslami Amirabadi, Poornima Nair, Cecilia M. Sahlgren, Jaap M. J. den Toonder   +4 more
doaj   +1 more source

3D cancer models: One step closer to in vitro human studies

Frontiers in Immunology, 2023
Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed prolonged progression-free survival over conventional therapies, yet, to date, in only a minority of patients.
Nicoletta Manduca, Ester Maccafeo, Ruggero De Maria, Ruggero De Maria, Antonella Sistigu, Martina Musella   +5 more
doaj   +1 more source

Tumor-on-a-chip platforms to study cancer–immune system crosstalk in the era of immunotherapy

Lab on a Chip, 2021
Immunotherapy is a powerful therapeutic approach able to re-educate the immune system to fight cancer. In this scenario, tumor-on-chip can help to choose the right immunotherapeutic treatment.
Parlato S., Grisanti G., Sinibaldi G., Peruzzi G., Casciola C. M., Gabriele L.   +5 more
openaire   +2 more sources

In vitro models of breast cancer bone metastasis: analyzing drug resistance through the lens of the microenvironment

Frontiers in Oncology, 2023
Even though breast cancers usually have a good outcome compared to other tumors, the cancer can progress and create metastases in different parts of the organism, the bone being a predilection locus.
Anaïs Lamouline, Anaïs Lamouline, Anaïs Lamouline, Simone Bersini, Simone Bersini, Simone Bersini, Matteo Moretti, Matteo Moretti, Matteo Moretti, Matteo Moretti   +9 more
doaj   +1 more source

High-resolution and multi-range particle separation by microscopic vibration in an optofluidic chip

, 2017
An optofluidic chip is demonstrated in experiments for high-resolution and multi-range particle separation through the optically-induced microscopic vibration effect, where nanoparticles are trapped in loosely overdamped optical potential wells created ...
Zhang, Jing Bo, Liedberg, B., Liedberg, Bo, P. H. Yap, Y. Zhang, Yap, P. H., Zhang, Yi, Xiong, S., Zhang, Y., Chen, T. N., Y. L. Hao, Chin, Lip Ket, Chin, L. K., S. Xiong, Shi, Yu Zhi, Ser, Wee, Y. Yang, W. Ser, Liu, A. Q., J. B. Zhang, Xiong, Sha, Hao, Yi Long, J. H. Wu, Hao, Y. L., Chen, Tian Ning, A. Q. Liu, Y. Z. Shi, Wu, Jiu Hui, Zhang, J. B., B. Liedberg, Yang, Z. C., Yang, Y., Wu, J. H., Ser, W., Yang, Zhen Chuan, Yap, Peng Huat, Shi, Y. Z., Liu, Ai Qun, T. N. Chen, Z. C. Yang, L. K. Chin, Yang, Yi   +41 more
core   +1 more source