Results 51 to 60 of about 138,643 (133)

Engineering perfusion to meet tumor biology: are vascularized tumor-on-a-chip models ready to drive therapy innovation?

Lab on a Chip
The development of effective cancer therapies remains constrained by the complex and dynamic nature of the tumor microenvironment (TME), with tumor vasculature representing a critical barrier and modulator of treatment response.
Ines Poljak, C. Chiappini, Giulia Adriani   +2 more
semanticscholar   +1 more source

Different Microfluidic Environments for In Vitro Testing of Lipid Nanoparticles against Osteosarcoma

Bioengineering, 2021
The use of lipid nanoparticles as biodegradable shells for controlled drug delivery shows promise as a more effective and targeted tumor treatment than traditional treatment methods.
Oihane Mitxelena-Iribarren, Sara Lizarbe-Sancha, Jay Campisi, Sergio Arana, Maite Mujika   +4 more
doaj   +1 more source

Advances in Modeling the Immune Microenvironment of Colorectal Cancer

Frontiers in Immunology, 2021
Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer-related death in the US. CRC frequently metastasizes to the liver and these patients have a particularly poor prognosis.
Paul Sukwoo Yoon, Nuala Del Piccolo, Venktesh S. Shirure, Yushuan Peng, Amanda Kirane, Robert J. Canter, Ryan C. Fields, Steven C. George, Sepideh Gholami   +8 more
doaj   +1 more source

Imaging Diffusion and Stability of Single‐Chain Polymeric Nanoparticles in a Multi‐Gel Tumor‐on‐a‐Chip Microfluidic Device

Small Methods
The performance of single‐chain polymeric nanoparticles (SCPNs) in biomedical applications highly depends on their conformational stability in cellular environments.
Linlin Deng, Alis R Olea, Ana Ortiz-Perez, Bingbing Sun, Jianhong Wang, S. Pujals, A. Palmans, L. Albertazzi   +7 more
semanticscholar   +1 more source

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety

Lab on a Chip, 2020
Traditional drug screening models are often unable to faithfully recapitulate human physiology in health and disease, motivating the development of microfluidic organs-on-a-chip (OOC) platforms that can mimic many aspects of human physiology and in the ...
Alan Chramiec, Diogo Teles, K. Yeager, Alessandro Marturano-Kruik, Joseph Pak, Timothy Chen, Luke Hao, Miranda C Wang, Roberta I. Lock, D. Tavakol, M. Lee, Jinho Kim, Kacey Ronaldson-Bouchard, G. Vunjak‐Novakovic   +13 more
semanticscholar   +1 more source

Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies.

Lab on a Chip, 2023
Over the past 15 years, the field of oncology research has witnessed significant progress in the development of new cell culture models, such as tumor-on-chip (ToC) systems.
Charlotte Bouquerel, A. Dubrova, Isabella Hofer, Duc T T Phan, Moencopi Bernheim, S. Ladaigue, C. Cavaniol, Danilo Maddalo, L. Cabel, F. Mechta‐Grigoriou, C. Wilhelm, Gérard Zalcman, M. Parrini, S. Descroix   +13 more
semanticscholar   +1 more source

Engineering choroid plexus-on-a-chip with oscillatory flow for modeling brain metastasis

Materials Today Bio, 2023
The human brain choroid plexus (ChP) is a highly organized secretory tissue with a complex vascular system and epithelial layers in the ventricles of the brain.
Jungeun Lim, Stephen Rhee, Hyeri Choi, Jungseub Lee, Shruthy Kuttappan, Tri Tho Yves Nguyen, Sunbeen Choi, YongTae Kim, Noo Li Jeon   +8 more
doaj   +1 more source

Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform

Lab on a Chip, 2016
The integration of three-dimensional micropatterning with microfluidics provides a unique opportunity to create perfusable tissue constructs in vitro. Herein, we have used this approach to create a tumor-on-chip with endothelial barrier. Specifically, we
Aereas Aung, Jomkuan Theprungsirikul, H. Lim, S. Varghese   +3 more
semanticscholar   +1 more source

Microfluidic-Based 3D Engineered Microvascular Networks and Their Applications in Vascularized Microtumor Models

Micromachines, 2018
The microvasculature plays a critical role in human physiology and is closely associated to various human diseases. By combining advanced microfluidic-based techniques, the engineered 3D microvascular network model provides a precise and reproducible ...
Xiaolin Wang, Qiyue Sun, Jianghua Pei
doaj   +1 more source

Emergent trends in organ-on-a-chip applications for investigating metastasis within tumor microenvironment: A comprehensive bibliometric analysis

Heliyon
Background: With the burgeoning advancements in disease modeling, drug development, and precision medicine, organ-on-a-chip has risen to the forefront of biomedical research.
Chunrong He, Fangfang Lu, Yi Liu, Yuanhu Lei, Xiaoxu Wang, Ning Tang   +5 more
doaj   +1 more source