Hybrid-integrated devices for mimicking malignant brain tumors (“tumor-on-a-chip”) for in vitro development of targeted drug delivery and personalized therapy approaches [PDF]
Frontiers in MedicineAcute and requiring attention problem of oncotheranostics is a necessity for the urgent development of operative and precise diagnostics methods, followed by efficient therapy, to significantly reduce disability and mortality of citizens.
Tatiana M. Zimina +6 more
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Bioprinting and its Use in Tumor-On-A-Chip Technology for Cancer Drug Screening: A Review [PDF]
International Journal of Bioprinting, 2022 The rising global incidence of cancer and high attrition rates of anticancer drugs make it imperative to design novel screening platforms to increase the success rate of chemotherapeutic agents. Advances in cell culture models from two-dimensional to three-dimensional platforms, along with microfluidics, have resulted in the creation of tumor-on-a-chip
Fang, Lingling +3 more
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Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine [PDF]
Science Advances, 2019 This colorectal tumor-on-chip model is an original and reliable platform for high-throughput drug screening and genetic expression.
M. R. Carvalho +7 more
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3D Collagen Vascular Tumor-on-a-Chip Mimetics for Dynamic Combinatorial Drug Screening [PDF]
Molecular Cancer Therapeutics, 2021 Abstract Disease models, including in vitro cell culture and animal models, have contributed significantly to developing diagnostics and treatments over the past several decades. The successes of traditional drug screening methods were generally hampered by not adequately mimicking critical in vivo features, such as a 3D ...
Li Wan +6 more
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Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors [PDF]
Lab on a Chip, 2020 Tumor progression is significantly influenced by factors such as mechanical force, shear stress, chemotaxis, and hypoxia. Here, we reviewed recent achievements and presented potential directions for tumor-on-a-chip systems in the future.
L. Wan, C. A. Neumann, P. R. LeDuc
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A Tumor‐on‐a‐Chip System with Bioprinted Blood and Lymphatic Vessel Pair [PDF]
Advanced Functional Materials, 2019 AbstractCurrent in vitro antitumor drug screening strategies insufficiently mimic biological systems. They tend to lack true perfusion and draining microcirculation systems, which may post significant limitations in explicitly reproducing the transport kinetics of cancer therapeutics.
Xia Cao +9 more
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Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients [PDF]
Lab on a Chip, 2019 Limited blood supply and rapid tumor metabolism within solid tumors leads to nutrient starvation, waste product accumulation and the generation of pH gradients across the tumor mass.
Jose M. Ayuso +9 more
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Study on Development of Composite Hydrogels With Tunable Structures and Properties for Tumor-on-a-Chip Research [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 A major factor for developing new tumor models is to recreate a proper three-dimensional environment for 3D tumors culture. In this 3D microenvironment, extracellular matrices play important roles in regulation of hallmark features of cancer through biochemical and mechanical signals.
Zaozao Chen +11 more
openaire +4 more sources
Engineered Vasculature for Organ-on-a-Chip Systems
Engineering, 2022 Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi +8 more
doaj +1 more source
Organ-on-a-chip Technology in Urology
Креативная хирургия и онкология, 2023 Organs-on-chips (OOC) refer to microfluidic devices used to create biomimetic systems of physiological organs. The system contains engineered or natural miniature tissues grown inside microfluidic chips.
A. G. Vardikian +4 more
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