Results 21 to 30 of about 127,911,481 (277)

Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients. [PDF]

Lab Chip, 2019
Limited blood supply and rapid tumor metabolism within solid tumors leads to nutrient starvation, waste product accumulation and the generation of pH gradients across the tumor mass.
Ayuso JM, Virumbrales-Munoz M, McMinn PH, Rehman S, Gomez I, Karim MR, Trusttchel R, Wisinski KB, Beebe DJ, Skala MC.   +9 more
europepmc   +2 more sources

Tumor-On-A-Chip Model Incorporating Human-Based Hydrogels for Easy Assessment of Metastatic Tumor Inter-Heterogeneity

Advanced Functional Materials
The coordinated migration of invasive tumor cells is a complex and dynamic mechanism driven by diverse cellular and molecular events. Unfortunately, the inherent heterogeneity within tumors raises multiple challenges in deciphering key biomarkers and ...
Cátia F Monteiro, João F. Mano, Catarina A. Custódio   +2 more
exaly   +2 more sources

Imaging Diffusion and Stability of Single‐Chain Polymeric Nanoparticles in a Multi‐Gel Tumor‐on‐a‐Chip Microfluidic Device [PDF]

Small Methods
The performance of single‐chain polymeric nanoparticles (SCPNs) in biomedical applications highly depends on their conformational stability in cellular environments.
Linlin Deng, Alis R Olea, Ana Ortiz-Perez, Bingbing Sun, Jian-Hong Wang, S. Pujals, A. Palmans, L. Albertazzi   +7 more
semanticscholar   +2 more sources

Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

Cell Reports, 2018
Summary: A major challenge in cancer research is the complexity of the tumor microenvironment, which includes the host immunological setting. Inspired by the emerging technology of organ-on-chip, we achieved 3D co-cultures in microfluidic devices ...
Marie Nguyen, Adele De Ninno, Arianna Mencattini, Fanny Mermet-Meillon, Giulia Fornabaio, Sophia S. Evans, Mélissande Cossutta, Yasmine Khira, Weijing Han, Philémon Sirven, Floriane Pelon, Davide Di Giuseppe, Francesca Romana Bertani, Annamaria Gerardino, Ayako Yamada, Stéphanie Descroix, Vassili Soumelis, Fatima Mechta-Grigoriou, Gérard Zalcman, Jacques Camonis, Eugenio Martinelli, Luca Businaro, Maria Carla Parrini   +22 more
doaj   +3 more sources

Spatiotemporal dissection of tumor microenvironment via in situ sensing and monitoring in tumor-on-a-chip [PDF]

Biosensors and Bioelectronics, 2023
Weiqiang Chen, Pengyu Chen, Lunan Liu
exaly   +2 more sources

Glioma-on-a-Chip Models

Micromachines, 2021
Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun, Sajjad Rahmani Dabbagh, Irem Sultan Ilci, Tugba Bagci-Onder, Savas Tasoglu   +4 more
doaj   +1 more source

Engineered Vasculature for Organ-on-a-Chip Systems

Engineering, 2022
Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi, Hongzhao Zhou, Yuting Li, Mengfei Yu, Xiaobin Xu, Yutong Wu, Liang Ma, Bin Zhang, Huayong Yang   +8 more
doaj   +1 more source

Organ-on-a-chip Technology in Urology

Креативная хирургия и онкология, 2023
Organs-on-chips (OOC) refer to microfluidic devices used to create biomimetic systems of physiological organs. The system contains engineered or natural miniature tissues grown inside microfluidic chips.
A. G. Vardikian, S. V. Piatnitskaia, V. A. Solntsev, B. I. Shamsov, V. N. Pavlov   +4 more
doaj   +1 more source

Analysis of Static Molecular Gradients in a High-Throughput Drug Screening Microfluidic Assay

Molecules, 2021
In this study, we thoroughly analyzed molecular gradient generation, its stability over time, and linearity in our high-throughput drug screening microfluidic assay (HTS).
Roman G. Szafran, Benita Wiatrak
doaj   +1 more source

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression [PDF]

Integrative Biology (United Kingdom), 2020
Ryan C Fields, John Meacham, Venktesh S Shirure   +2 more
exaly   +2 more sources