3D-Printed Tumor-on-a-Chip Model for Investigating the Effect of Matrix Stiffness on Glioblastoma Tumor Invasion [PDF]
Biomimetics, 2023 Glioblastoma multiform (GBM) tumor progression has been recognized to be correlated with extracellular matrix (ECM) stiffness. Dynamic variation of tumor ECM is primarily regulated by a family of enzymes which induce remodeling and degradation.
Meitham Amereh +5 more
doaj +2 more sources
Extracellular matrix regulation of cell spheroid invasion in a 3D bioprinted solid tumor-on-a-chip. [PDF]
Acta BiomaterTumor organoids and tumors-on-chips can be built by placing patient-derived cells within an extracellular matrix (ECM) for personalized medicine. The ECM influences the tumor response, and understanding the ECM-tumor relationship is important before ...
Dogan E +5 more
europepmc +2 more sources
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors. [PDF]
Lab Chip, 2020 Tumor progression, including metastasis, is significantly influenced by factors in the tumor microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia.
Wan L, Neumann CA, LeDuc PR.
europepmc +2 more sources
High-Throughput Tumor-on-a-Chip Platform to Study Tumor-Stroma Interactions and Drug Pharmacokinetics. [PDF]
Adv Healthc Mater, 2020 Drug screening in oncology, especially for triple‐negative breast cancer (TNBC), has high demand but remains unsatisfactory. Currently available models are either nonrepresentative of the complex tumor microenvironment or only suitable for low throughput
Chi CW +8 more
europepmc +2 more sources
Magnetic hyperthermia therapy in glioblastoma tumor on-a-Chip model. [PDF]
Einstein (Sao Paulo), 2020 Objective: To evaluate the magnetic hyperthermia therapy in glioblastoma tumor-on-a-Chip model using a microfluidics device. Methods: The magnetic nanoparticles coated with aminosilane were used for the therapy of magnetic hyperthermia, being evaluated ...
Mamani JB +8 more
europepmc +2 more sources
Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system [PDF]
Journal of Nanobiotechnology, 2022 Despite explosive growth in the development of nano-drug delivery systems (NDDS) targeting tumors in the last few decades, clinical translation rates are low owing to the lack of efficient models for evaluating and predicting responses.
Chutong Tian +3 more
doaj +2 more sources
An Advanced 3D Model of Vascularized Epithelial Ovarian Cancer in a Tumor-on-a-Chip System Based on Multi-Cell Culture [PDF]
SensorsEpithelial ovarian cancer (EOC) is a highly lethal malignancy characterized by significant heterogeneity and poor prognosis due to late-stage diagnosis and chemotherapy resistance.
Magdalena Flont +7 more
doaj +2 more sources
Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity. [PDF]
Tissue Eng Part C Methods, 2020 Cancer remains a leading health threat in the United States, and cardiovascular drug toxicity is a primary cause to eliminate a drug from FDA approval. As a result, the demand to develop new anticancer drugs without cardiovascular toxicity is high. Human
Weng KC +5 more
europepmc +2 more sources
Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids. [PDF]
Lab Chip, 2018 Most cancer treatment strategies target cell proliferation, angiogenesis, migration, and intravasation of tumor cells in an attempt to limit tumor growth and metastasis.
Shirure VS +8 more
europepmc +2 more sources
Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients. [PDF]
Lab Chip, 2019 Limited blood supply and rapid tumor metabolism within solid tumors leads to nutrient starvation, waste product accumulation and the generation of pH gradients across the tumor mass.
Ayuso JM +9 more
europepmc +2 more sources