Organ-Tumor-on-a-Chip for Chemosensitivity Assay: A Critical Review
Micromachines, 2016 With a mortality rate over 580,000 per year, cancer is still one of the leading causes of death worldwide. However, the emerging field of microfluidics can potentially shed light on this puzzling disease.
Navid Kashaninejad +7 more
doaj +4 more sources
3D Collagen Vascular Tumor-on-a-Chip Mimetics for Dynamic Combinatorial Drug Screening. [PDF]
Mol Cancer Ther, 2021 Disease models, including in vitro cell culture and animal models, have contributed significantly to developing diagnostics and treatments over the past several decades.
Wan L +6 more
europepmc +2 more sources
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors. [PDF]
Lab Chip, 2020 Tumor progression, including metastasis, is significantly influenced by factors in the tumor microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia.
Wan L, Neumann CA, LeDuc PR.
europepmc +2 more sources
Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format. [PDF]
Nanomaterials (Basel)This study addresses issues in developing spatially controlled magnetic fields for particle guidance, synthesizing biocompatible and chemically stable MNPs and enhancing their specificity to pathological cells through chemical modifications, developing ...
Zimina T +9 more
europepmc +2 more sources
Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability. [PDF]
Int J Mol Sci, 2020 Tumor-specific metabolic adaptations offer an interesting therapeutic opportunity to selectively destroy cancer cells. However, solid tumors also present gradients of nutrients and waste products across the tumor mass, forcing tumor cells to adapt their ...
Ayuso JM +6 more
europepmc +2 more sources
High-Throughput Tumor-on-a-Chip Platform to Study Tumor-Stroma Interactions and Drug Pharmacokinetics. [PDF]
Adv Healthc Mater, 2020 Drug screening in oncology, especially for triple‐negative breast cancer (TNBC), has high demand but remains unsatisfactory. Currently available models are either nonrepresentative of the complex tumor microenvironment or only suitable for low throughput
Chi CW +8 more
europepmc +2 more sources
Recapitulating Solid Stress on Tumor on a Chip for Nanomedicine Diffusive Transport Prediction
Advanced NanoBiomed Research, 2023 The characteristic mechanical forces at play within tumors include the abnormal solid and fluid stresses. These, together with the increased extracellular matrix (ECM) stiffness, are the major transport barriers affecting the nanomedicine delivery to ...
Alberto Martín-Asensio +8 more
doaj +2 more sources
Tumor-On-A-Chip Models for Predicting In Vivo Nanoparticle Behavior
SmallNanosized drug formulations are broadly explored for the improvement of cancer therapy. Prediction of in vivo nanoparticle (NP) behavior, however, is challenging, given the complexity of the tumor and its microenvironment.
Wouter P R Verdurmen, Roland Brock
exaly +2 more sources
Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system [PDF]
Journal of Nanobiotechnology, 2022 Despite explosive growth in the development of nano-drug delivery systems (NDDS) targeting tumors in the last few decades, clinical translation rates are low owing to the lack of efficient models for evaluating and predicting responses.
Chutong Tian +3 more
doaj +2 more sources
An Advanced 3D Model of Vascularized Epithelial Ovarian Cancer in a Tumor-on-a-Chip System Based on Multi-Cell Culture [PDF]
SensorsEpithelial ovarian cancer (EOC) is a highly lethal malignancy characterized by significant heterogeneity and poor prognosis due to late-stage diagnosis and chemotherapy resistance.
Magdalena Flont +7 more
doaj +2 more sources