Results 11 to 20 of about 91,694,512 (315)
Recapitulating Solid Stress on Tumor on a Chip for Nanomedicine Diffusive Transport Prediction
Advanced NanoBiomed Research, 2023 The characteristic mechanical forces at play within tumors include the abnormal solid and fluid stresses. These, together with the increased extracellular matrix (ECM) stiffness, are the major transport barriers affecting the nanomedicine delivery to ...
Alberto Martín-Asensio +8 more
doaj +5 more sources
Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system [PDF]
Journal of Nanobiotechnology, 2022 Despite explosive growth in the development of nano-drug delivery systems (NDDS) targeting tumors in the last few decades, clinical translation rates are low owing to the lack of efficient models for evaluating and predicting responses.
Chutong Tian +3 more
doaj +4 more sources
Tumor-on-a-chip: from bioinspired design to biomedical application [PDF]
Microsystems & Nanoengineering, 2021 AbstractCancer is one of the leading causes of human death, despite enormous efforts to explore cancer biology and develop anticancer therapies. The main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring efficient means for screening anticancer drugs to reveal the nature of cancer and develop ...
Xingxing Liu +9 more
openaire +4 more sources
Vascularized Tumor‐on‐a‐Chip Model as a Platform for Studying Tumor‐Microenvironment‐Drug Interaction [PDF]
Macromolecular BioscienceABSTRACTAs cancer‐targeting technologies advance, robust platforms for evaluating drug delivery systems (DDS) under pathomimetic conditions are critically needed. Traditional models inadequately mimic human tumor microenvironment (TME) complexity due to interspecies variance, structural simplification, and static perfusion. Vascularized tumor‐on‐a‐chip
Hyelim Kim +2 more
europepmc +4 more sources
From Spheroids to Tumor-on-a-Chip for Cancer Modeling and Therapeutic Testing [PDF]
MicromachinesThe high failure rate of anticancer drugs in clinical trials highlights the need for preclinical models that accurately reproduce the structural, biochemical, and mechanical complexity of human tumors. Conventional two-dimensional cultures and animal models often lack the physiological complexity required to predict clinical outcomes, driving the ...
Lipreri, Maria Veronica +3 more
openaire +5 more sources
Tumor-on-a-chip: Perfusable vascular incorporation brings new approach to tumor metastasis research and drug development [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 The extracellular matrix interacts with cancer cells and is a key factor in the development of cancer. Traditional two-dimensional models cannot mimic the natural in situ environment of cancer tissues, whereas three-dimensional (3D) models such as ...
Ruixin Wang +3 more
doaj +2 more sources
3D-Printed Tumor-on-a-Chip Model for Investigating the Effect of Matrix Stiffness on Glioblastoma Tumor Invasion [PDF]
Biomimetics, 2023 Glioblastoma multiform (GBM) tumor progression has been recognized to be correlated with extracellular matrix (ECM) stiffness. Dynamic variation of tumor ECM is primarily regulated by a family of enzymes which induce remodeling and degradation.
Meitham Amereh +5 more
doaj +2 more sources
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology [PDF]
Medicinal Research Reviews, 2022 AbstractThe complexity of the tumor microenvironment (TME) together with the development of the metastatic process are the main reasons for the failure of conventional anticancer treatment. In recent years, there is an increasing need to advance toward advanced in vitro models of cancer mimicking TME and simulating metastasis to understand the ...
Daniel Nieto +5 more
openaire +5 more sources
Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability [PDF]
International Journal of Molecular Sciences, 2020 Tumor-specific metabolic adaptations offer an interesting therapeutic opportunity to selectively destroy cancer cells. However, solid tumors also present gradients of nutrients and waste products across the tumor mass, forcing tumor cells to adapt their metabolism depending on nutrient availability in the surrounding microenvironment.
Jose M Ayuso +6 more
openaire +3 more sources
Magnetic hyperthermia therapy in glioblastoma tumor on-a-Chip model [PDF]
Einstein (São Paulo), 2019 To evaluate the magnetic hyperthermia therapy in glioblastoma tumor-on-a-Chip model using a microfluidics device.The magnetic nanoparticles coated with aminosilane were used for the therapy of magnetic hyperthermia, being evaluated the specific absorption rate of the magnetic nanoparticles at 300 Gauss and 305kHz. A preculture of C6 cells was performed
Javier Bustamante Mamani +8 more
openaire +6 more sources