In vitro modelling of extracellular matrix changes during skin aging: from static 2D to 3D dynamic microphysiological systems [PDF]
Microsystems & NanoengineeringSkin aging results from a combination of intrinsic factors and exogenous stimuli, leading to changes in the structure and components of the extracellular matrix (including the skin basement membrane), which directly influence the aging process.
Yu Yao +9 more
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Human Microphysiological Systems and Organoids as in Vitro Models for Toxicological Studies
Frontiers in Public Health, 2018 Organoids and microphysiological systems represent two current approaches to reproduce organ function in vitro. These systems can potentially provide unbiased assays of function which are needed to understand the mechanism of action of environmental ...
George A. Truskey
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Microphysiological systems for solid tumor immunotherapy: opportunities and challenges [PDF]
Microsystems & Nanoengineering, 2023 Immunotherapy remains more effective for hematologic tumors than for solid tumors. One of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate, which limits the cytotoxic capabilities of ...
Sara Abizanda-Campo +7 more
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Bioengineering ethics for the age of microphysiological systems [PDF]
Frontiers in Bioengineering and BiotechnologyThe development of microphysiological systems (MPS) is pushing ethical standards in biomedical research to a breaking point. This article argues that only a perspective drawing from engineering ethics will be able to address the new challenges raised by ...
Maxence Gaillard, Maxence Gaillard
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Ultrastructural Study of Microphysiological Systems of the Tumor Microenvironment [PDF]
Small ScienceThe importance of studying the ultrastructure is underwritten by decades of research. Ultrastructural features help to understand pathological processes or inform disease diagnosis.
Paula Guerrero‐López +5 more
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Strategies to control cellular spatial organization in microphysiological systems [PDF]
Microsystems & NanoengineeringSpatial organization is fundamental to tissue physiology, as it governs how cells migrate, grow, differentiate, and interact within their native environments.
Hung Dong Truong +5 more
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Pillar arrays as tunable interfacial barriers for microphysiological systems [PDF]
Communications EngineeringWe report on the design and fabrication of a circular pillar array as an interfacial barrier for microfluidic microphysiological systems (MPS). Traditional barrier interfaces, such as porous membranes and microchannel arrays, present limitations due to ...
Ishan Goswami +8 more
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Time and architecture: the next two dimensions of microphysiological systems [PDF]
npj Biomedical InnovationsMicrophysiological models recapitulating complex vasculature have enabled in vitro evaluation of intricate cellular crosstalk and microenvironmental mechanical cues and stressors.
Rashmi Pandey +4 more
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Microphysiological systems as models for immunologically ‘cold’ tumors [PDF]
Frontiers in Cell and Developmental BiologyThe tumor microenvironment (TME) is a diverse milieu of cells including cancerous and non-cancerous cells such as fibroblasts, pericytes, endothelial cells and immune cells.
Daniela Gaebler +3 more
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Leveraging microphysiological systems to expedite understanding of host-parasite interactions. [PDF]
PLoS PathogensMicrophysiological systems (MPS) replicate the dynamic interactions between cells, tissues, and fluids. They have emerged as transformative tools for biology and have been increasingly applied to host-parasite interactions.
Maria Zorrinho-Almeida +3 more
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