Results 1 to 10 of about 4,523 (149)

Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy. [PDF]

Adv Sci (Weinh)
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shao S, Diehl MI, Jones CN.
europepmc   +2 more sources

Hemadyne: accordion-inspired perfusion for microphysiological systems [PDF]

Nature Communications
A crucial factor limiting the physiological relevance, reproducibility and ease of adoption of microphysiological systems is the constrained non-specific design and performance of existing perfusion systems. Inspired by the physics of the accordion music
Ankit Kumar, Shivanand Pattanshetti, Rushangi D. Patel, Rashmi Pandey, Ethan Mahalingam, Elaheh Rahbar, Abhishek Jain   +6 more
doaj   +2 more sources

Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform [PDF]

Experimental Biology and Medicine
The advancement in the use of all-human high content microphysiological systems (MPS) has enabled better in vitro modeling of liver function and disease progression as well as drug efficacy, metabolism and toxicity (ADME-Tox) testing.
Dillon C. Gavlock, Michael W. Castiglione, Allen Wang, Mahboubeh Varmazyad, Mahboubeh Varmazyad, Mahboubeh Varmazyad, Lawrence A. Vernetti, Lawrence A. Vernetti, Lawrence A. Vernetti, Mark E. Schurdak, Mark E. Schurdak, Mark E. Schurdak, D. Lansing Taylor, D. Lansing Taylor, D. Lansing Taylor, Jacquelyn A. Brown, Jacquelyn A. Brown, Jacquelyn A. Brown, Mark T. Miedel, Mark T. Miedel, Mark T. Miedel   +20 more
doaj   +2 more sources

Ethical Challenges and Governance Strategies for Microphysiological Systems Technology [PDF]

Biology
Microphysiological Systems (MPS) have emerged as a transformative platform in biomedical research, enabling the investigation of disease mechanisms, drug screening, and toxicity prediction by closely simulating human physiological functions. However, the
Manman Zhao, Tian Lin, Ruiqiu Zhang, Haodong Zhong, Qianyi Niu, Xiaobing Zhou, Qingli Wang   +6 more
doaj   +2 more sources

In vitro modelling of extracellular matrix changes during skin aging: from static 2D to 3D dynamic microphysiological systems [PDF]

Microsystems & Nanoengineering
Skin aging results from a combination of intrinsic factors and exogenous stimuli, leading to changes in the structure and components of the extracellular matrix (including the skin basement membrane), which directly influence the aging process.
Yu Yao, Zilin Zhang, Jing Zhang, Yuan Gao, Xiaoran Li, Keyu Yang, Nuo Si, Zaozao Chen, Zhongze Gu, Ningbei Yin   +9 more
doaj   +2 more sources

Bioengineering ethics for the age of microphysiological systems [PDF]

Frontiers in Bioengineering and Biotechnology
The development of microphysiological systems (MPS) is pushing ethical standards in biomedical research to a breaking point. This article argues that only a perspective drawing from engineering ethics will be able to address the new challenges raised by ...
Maxence Gaillard, Maxence Gaillard
doaj   +2 more sources

Strategies to control cellular spatial organization in microphysiological systems [PDF]

Microsystems & Nanoengineering
Spatial organization is fundamental to tissue physiology, as it governs how cells migrate, grow, differentiate, and interact within their native environments.
Hung Dong Truong, Zhixing Ge, Elgene Chng, Y-Van Tran, Yusheng Zhang, Chwee Teck Lim   +5 more
doaj   +2 more sources

Pillar arrays as tunable interfacial barriers for microphysiological systems [PDF]

Communications Engineering
We report on the design and fabrication of a circular pillar array as an interfacial barrier for microfluidic microphysiological systems (MPS). Traditional barrier interfaces, such as porous membranes and microchannel arrays, present limitations due to ...
Ishan Goswami, Yongdeok Kim, Gabriel Neiman, Brian Siemons, Jazmin I. Velazquez, Kerem Yazgan, Tammy Ng, Sudipta Ashe, Kevin E. Healy   +8 more
doaj   +2 more sources

Training the Next Generation of Researchers in the Organ-on-Chip Field

Education Sciences, 2023
Organ-on-chip (OoC) technology bridges the principles of biology and engineering to create a new generation of in vitro models and involves highly interdisciplinary collaboration across STEM disciplines.
Alessia Moruzzi, Tanvi Shroff, Silke Keller, Peter Loskill, Madalena Cipriano   +4 more
doaj   +1 more source

Autologous Human Immunocompetent White Adipose Tissue‐on‐Chip

Advanced Science, 2022
Obesity and associated diseases, such as diabetes, have reached epidemic proportions globally. In this era of “diabesity”, white adipose tissue (WAT) has become a target of high interest for therapeutic strategies.
Julia Rogal, Julia Roosz, Claudia Teufel, Madalena Cipriano, Raylin Xu, Wiebke Eisler, Martin Weiss, Katja Schenke‐Layland, Peter Loskill   +8 more
doaj   +1 more source