Results 1 to 10 of about 4,082 (188)
Bioengineering ethics for the age of microphysiological systems [PDF]
Frontiers in Bioengineering and BiotechnologyThe development of microphysiological systems (MPS) is pushing ethical standards in biomedical research to a breaking point. This article argues that only a perspective drawing from engineering ethics will be able to address the new challenges raised by ...
Maxence Gaillard, Maxence Gaillard
doaj +4 more sources
Gastrointestinal microphysiological systems [PDF]
Experimental Biology and Medicine, 2017 Gastrointestinal diseases are a significant health care and economic burden. Prevention and treatment of these diseases have been limited by the available human biologic models. Microphysiological systems comprise organ-specific human cultures that recapitulate many structural, biological, and functional properties of the organ in smaller scale ...
Julie Goeun In +2 more
exaly +3 more sources
Modeling immunity in microphysiological systems. [PDF]
Exp Biol Med (Maywood), 2023 There is a need for better predictive models of the human immune system to evaluate safety and efficacy of immunomodulatory drugs and biologics for successful product development and regulatory approvals. Current in vitro models, which are often tested in two-dimensional (2D) tissue culture polystyrene, and preclinical animal models fail to fully ...
Kwee BJ +5 more
europepmc +3 more sources
Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform [PDF]
Experimental Biology and MedicineThe advancement in the use of all-human high content microphysiological systems (MPS) has enabled better in vitro modeling of liver function and disease progression as well as drug efficacy, metabolism and toxicity (ADME-Tox) testing.
Dillon C. Gavlock +20 more
doaj +2 more sources
In vitro modelling of extracellular matrix changes during skin aging: from static 2D to 3D dynamic microphysiological systems [PDF]
Microsystems & NanoengineeringSkin aging results from a combination of intrinsic factors and exogenous stimuli, leading to changes in the structure and components of the extracellular matrix (including the skin basement membrane), which directly influence the aging process.
Yu Yao +9 more
doaj +2 more sources
Human Microphysiological Systems and Organoids as in Vitro Models for Toxicological Studies
Frontiers in Public Health, 2018 Organoids and microphysiological systems represent two current approaches to reproduce organ function in vitro. These systems can potentially provide unbiased assays of function which are needed to understand the mechanism of action of environmental ...
George A. Truskey
doaj +3 more sources
Microphysiological Systems: Design, Fabrication, and Applications
ACS Biomaterials Science and Engineering, 2020 Microphysiological systems, including organoids, 3-D printed tissue constructs and organ-on-a-chips (organ chips), are physiologically relevant in vitro models and have experienced explosive growth in the past decades. Different from conventional, tissue culture plastic-based in vitro models or animal models, microphysiological systems recapitulate key
, , Kun Man
exaly +4 more sources
Microphysiological Systems of Lymphatics and Immune Organs. [PDF]
Adv Healthc MaterAbstract Microphysiological systems (MPS) that incorporate engineered blood vasculatures have enabled new opportunities to study human physiology and disease, offering platforms for drug development, tissue modeling, and regenerative medicine.
Jain I, Singh A, García AJ.
europepmc +3 more sources
Microphysiological systems [PDF]
APL Bioengineering, 2019 James J. Hickman +2 more
doaj +3 more sources
Ultrastructural Study of Microphysiological Systems of the Tumor Microenvironment [PDF]
Small ScienceThe importance of studying the ultrastructure is underwritten by decades of research. Ultrastructural features help to understand pathological processes or inform disease diagnosis.
Paula Guerrero‐López +5 more
doaj +2 more sources