Results 41 to 50 of about 4,082 (188)

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses

Communications Biology, 2021
Alave-Furrer et al adapted their recently-developed 3D bioprinting platform to allow microvalve-based drop-on-demand printing of cell-laden Matrigel containing primary human muscle precursor cells.
Angela Alave Reyes-Furrer, Sonia De Andrade, Dominic Bachmann, Heidi Jeker, Martin Steinmann, Nathalie Accart, Andrew Dunbar, Martin Rausch, Epifania Bono, Markus Rimann, Hansjoerg Keller   +10 more
doaj   +1 more source

Mera: A scalable high throughput automated micro-physiological system

SLAS Technology, 2023
There is an urgent need for scalable Microphysiological Systems (MPS's)11 Microphysiological systems (MPSs), Microtissue (MT), Polyetheretherketone (PEEK), Polytetrafluoroethylene (PTFE), Polystyrene (PS) that can better predict drug efficacy and ...
Finola E. Cliffe, Conor Madden, Patrick Costello, Shane Devitt, Sumir Ramesh Mukkunda, Bhairavi Bengaluru Keshava, Howard O. Fearnhead, Aiste Vitkauskaite, Mahshid H. Dehkordi, Walter Chingwaru, Milosz Przyjalgowski, Natalia Rebrova, Mark Lyons   +12 more
doaj   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Microphysiological system design: simplicity is elegance

Current Opinion in Biomedical Engineering, 2020
Design parameters for microphysiological systems (MPS) are driven by the need for new tools to answer questions focusing on human physiology in a robust and reliable manner. Within this perspective, engineering benchmarks and principles are identified to guide the construction of new devices in the MPS field, with emphasis placed on the design ...
Samuel S. Hinman, Raehyun Kim, Yuli Wang, K. Scott Phillips, Peter J. Attayek, Nancy L. Allbritton   +5 more
openaire   +3 more sources

Tomographic Printing in a Chip: A Versatile Platform for Biomimetic 3D Organ‐on‐Chip

Advanced Healthcare Materials, EarlyView.
A novel light‐based bioprinting approach, TVAM‐in‐a‐chip, enables rapid, contactless fabrication of biomimetic 3D organ‐on‐chip devices directly within preassembled microfluidic platforms. This strategy supports diverse materials, including cell‐laden resins, and eliminates post‐assembly steps.
Riccardo Rizzo, Viola Sgarminato, Felix Wechsler, Christophe Moser   +3 more
wiley   +1 more source

Long‐Term Stability of Bacterial Extracellular Vesicles Stored at Different Temperatures

Journal of Extracellular Biology
Extracellular vesicle (EV) research has revealed EV involvement in a variety of biological processes, with potential applications in both fundamental research and therapeutic development.
Anagha Rama Varma, Frank Borris, Parnika Kant, Kaitlyn Sadtler, Parinaz Fathi   +4 more
doaj   +1 more source

Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening

Bioactive Materials
Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the ...
Yuxuan Zhu, Deming Jiang, Yong Qiu, Xin Liu, Yuhan Bian, Shichao Tian, Xiandi Wang, K. Jimmy Hsia, Hao Wan, Liujing Zhuang, Ping Wang   +10 more
doaj   +1 more source

Patterned ELR‐Gelatin Hydrogels Enable Rapid Endothelial Monolayer Formation via Bioactive Matrix Chemistry and Surface Topography

Advanced Healthcare Materials, EarlyView.
Micro‐ and nano‐patterned elastin‐like recombinamer (ELR) hydrogels integrate bioactive matrix chemistry with defined surface topography. The combined cues promote rapid endothelial cell capture, alignment, and monolayer formation on soft substrates.
Jagoda Litowczenko, Yannick Richter, Martyna Michalska, Piotr Paczos, Karine Tadevosyan, Daniel Uribe, Jose Carlos Rodriguez‐Cabello, Ioannis Papakonstantinou, Angel Raya   +8 more
wiley   +1 more source

Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation in Drosophila

Cell & Bioscience
Most neural stem cells (NSCs) maintain self-renewal to ensure proper development of central nervous system (CNS) until a specific time and undergo terminal differentiation after neurogenesis.
Shuliu Zhang, Sifan Gong, Yiming Yang, Wenting Gong, Qingxia Zhou, Kun Yang, Menglong Rui, Su Wang   +7 more
doaj   +1 more source