Results 41 to 50 of about 6,641 (226)
3D printed scaffolds: Challenges toward developing relevant cellular in vitro models
Biomaterials and Biosystems, 2022 Three-dimensional (3D) cell culture technology has rapidly emerged, as a result of the increasing demand for improved in vitro systems that better resemble human physiology.
Beatriz Molina-Martínez +1 more
doaj +1 more source
Modelling the innate immune system in microphysiological systems.
Lab ChipIntegration of an immune component moves the field closer to a physiologically relevant human-on-a-chip.
Rupar MJ +5 more
europepmc +3 more sources
In vitro tissue microarrays for quick and efficient spheroid characterisation [PDF]
, 2018 Three-dimensional in vitro microphysiological cultures, such as spheroids and organoids, promise increased patient relevance and therapeutic predictivity compared to reductionist cell monolayers.
A. M. Grabowska, D. P. Ivanov, Subik K.
core +2 more sources
Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models [PDF]
, 2020 Natural tissues are incorporated with vasculature, which is further integrated with a cardiovascular system responsible for driving perfusion of nutrient‐rich oxygenated blood through the vasculature to support cell metabolism within most cell‐dense ...
Bonewald, Lynda F. +8 more
core +1 more source
Microphysiologic systems in female reproductive biology [PDF]
Experimental Biology and Medicine, 2017 Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a
Alexandria N, Young +3 more
openaire +2 more sources
Rapid Prototyping of Multilayer Microphysiological Systems
ACS Biomaterials Science & Engineering, 2020 Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared to traditional two-dimensional (2D) static cell culture. Often such devices are fabricated via poly(dimethylsiloxane) (PDMS) soft lithography, which offers benefits (e.g., high feature resolution) along with drawbacks (e.g., prototyping time/costs).
Sanjin Hosic +9 more
openaire +3 more sources
Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused 3D human liver bioreactor [PDF]
, 2015 Endotoxin lipopolysaccharide (LPS) is known to cause liver injury primarily involving inflammatory cells such as Kupffer cells, but few in vitro culture models are applicable for investigation of inflammatory effects on drug metabolism. We have developed
Dyer, Rachel Lee +9 more
core +1 more source
Modeling early stage atherosclerosis in a primary human vascular microphysiological system
Nature Communications, 2020 Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of several
Xu Zhang +7 more
doaj +1 more source
Communications Biology, 2021 Alave-Furrer et al adapted their recently-developed 3D bioprinting platform to allow microvalve-based drop-on-demand printing of cell-laden Matrigel containing primary human muscle precursor cells.
Angela Alave Reyes-Furrer +10 more
doaj +1 more source
, 2018 © 2017 The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases.
Beckwitt, Colin H. +6 more
core +1 more source