Results 41 to 50 of about 4,031 (174)
Advanced Healthcare Materials, EarlyView.Packed hydrogel microfiber (PHM) materials consist of flexible and high aspect ratio hydrogel components that, as a bulk material, are simultaneously mechanically robust and dynamic. Cells cultured in or on PHM scaffolds can be influenced by topographical cues or interact with a dynamic environment that permits cell spreading and multicellular ...
M. Gregory Grewal +7 more
wiley +1 more source
Microphysiological system design: simplicity is elegance
Current Opinion in Biomedical Engineering, 2020 Design parameters for microphysiological systems (MPS) are driven by the need for new tools to answer questions focusing on human physiology in a robust and reliable manner. Within this perspective, engineering benchmarks and principles are identified to guide the construction of new devices in the MPS field, with emphasis placed on the design ...
Samuel S. Hinman +5 more
openaire +3 more sources
Biomarker ResearchNeoantigens, which are tumor-specific peptides generated by malignant cells, can be presented to T cells to elicit immune responses. Owing to their tumor-specific properties, neoantigens have emerged as one of the most promising biomarkers and targets ...
Zhenchang Wang +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha +9 more
wiley +1 more source
An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids
Advanced Materials Technologies, EarlyView.This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto +6 more
wiley +1 more source
Neodymium‐Doped Nanocrystals for Sensing Cellular Temperature at the Nanoscale
Advanced Optical Materials, EarlyView.Neodymium‐doped NaYF4 nanocrystals are engineered as bright, biocompatible nanothermometers for intracellular temperature mapping. Their ratiometric near‐infrared emission enables highly sensitive, nanoscale thermal readouts in living cells. Combined with gold nanostars for photothermal therapy, they reveal pronounced subcellular heating heterogeneity ...
Maria Bravo +13 more
wiley +1 more source
Long‐Term Stability of Bacterial Extracellular Vesicles Stored at Different Temperatures
Journal of Extracellular BiologyExtracellular vesicle (EV) research has revealed EV involvement in a variety of biological processes, with potential applications in both fundamental research and therapeutic development.
Anagha Rama Varma +4 more
doaj +1 more source
Bioactive MaterialsSpheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the ...
Yuxuan Zhu +10 more
doaj +1 more source
Bioengineering, 2023 The liver is one of the key organs for exogenous and endogenous metabolism and is often a target for drug- and chemical-driven toxicity. A wide range of experimental approaches has been established to model and characterize the mechanisms of drug- and ...
Alicia Y. Lim +11 more
doaj +1 more source
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source