Results 41 to 50 of about 8,980,611 (179)

Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics

Advanced Science, EarlyView.
Brain organoids are emerging as increasingly functional human‐relevant platforms, yet limitations in vascularization, maturation, measurement, and reproducibility still constrain their translational value. This Perspective examines how microfluidics, biofabrication, advanced imaging, electrophysiology, multimodal AI, standardization, and ethical ...
Aishwarya Pantula, Kaustubh Joshi, Swarangi Samant, Greta Babakhanova, Annie Kathuria   +4 more
wiley   +1 more source

Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges

, 2017
Traditional cell culture and animal models utilized for preclinical drug screening have led to high attrition rates of drug candidates in clinical trials due to their low predictive power for human response.
Carlos Carmona, Wang, Ying I., James J. Hickman, Shuler, Michael L., Michael L. Shuler, Ying I. Wang, Carmona, Carlos, Hickman, James J.   +7 more
core   +1 more source

Leveraging microphysiological systems to expedite understanding of host-parasite interactions. [PDF]

PLoS Pathog
Microphysiological systems (MPS) replicate the dynamic interactions between cells, tissues, and fluids. They have emerged as transformative tools for biology and have been increasingly applied to host–parasite interactions.
Zorrinho-Almeida M, de-Carvalho J, Bernabeu M, Silva Pereira S.   +3 more
europepmc   +2 more sources

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Application of lung microphysiological systems to COVID-19 modeling and drug discovery: a review [PDF]

, 2021
There is a pressing need for effective therapeutics for coronavirus disease 2019 (COVID-19), the respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus.
Ashammakhi, Nureddin, Li, Song, Sun, Argus M, Luu, Bao Q, Hoffman, Tyler   +4 more
core   +1 more source

Long‐Term Stability of Bacterial Extracellular Vesicles Stored at Different Temperatures

Journal of Extracellular Biology
Extracellular vesicle (EV) research has revealed EV involvement in a variety of biological processes, with potential applications in both fundamental research and therapeutic development.
Anagha Rama Varma, Frank Borris, Parnika Kant, Kaitlyn Sadtler, Parinaz Fathi   +4 more
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation in Drosophila

Cell & Bioscience
Most neural stem cells (NSCs) maintain self-renewal to ensure proper development of central nervous system (CNS) until a specific time and undergo terminal differentiation after neurogenesis.
Shuliu Zhang, Sifan Gong, Yiming Yang, Wenting Gong, Qingxia Zhou, Kun Yang, Menglong Rui, Su Wang   +7 more
doaj   +1 more source

Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses

Communications Biology, 2021
Alave-Furrer et al adapted their recently-developed 3D bioprinting platform to allow microvalve-based drop-on-demand printing of cell-laden Matrigel containing primary human muscle precursor cells.
Angela Alave Reyes-Furrer, Sonia De Andrade, Dominic Bachmann, Heidi Jeker, Martin Steinmann, Nathalie Accart, Andrew Dunbar, Martin Rausch, Epifania Bono, Markus Rimann, Hansjoerg Keller   +10 more
doaj   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source