Results 61 to 70 of about 8,980,611 (179)
International Journal of Extreme ManufacturingThe pursuit of 3D structures with precise microarchitectures and broad material adaptability has long been a central scientific objective, given their transformative potential to tackle critical challenges across applications such as vascular networks ...
Wenwan Shi +10 more
doaj +1 more source
Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy
Advanced Science, EarlyView.A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao +10 more
wiley +1 more source
Advanced Science, EarlyView.An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma +14 more
wiley +1 more source
Scalable manufacturing of microphysiological systems to extend the production volume
1316Microphysiological systems (MPS) have emerged as a valuable tool in preclinical drug testing. These systems are capable of simulating in vivo conditions and physiological functions within an ex vivo tissue culture setting, resulting in improved ...
Philipp, Jürgen +4 more
core +1 more source
Engineering cardiac microphysiological systems to model pathological extracellular matrix remodeling
, 2018 Many cardiovascular diseases are associated with pathological remodeling of the extracellular matrix (ECM) in the myocardium. ECM remodeling is a complex, multifactorial process that often contributes to declines in myocardial function and progression ...
Davi M. Lyra-Leite +2 more
core +1 more source
, 2021 Advances in bioengineered microphysiological systems/organ-on-chip technologies provide in vitro models with greater physiological relevance and create opportunities to further investigate pregnancy and its complications.
Roberts, C.T. +4 more
core +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced ScienceReliable modeling of human adaptive immune responses is a prerequisite to understand processes leading to vaccine‐induced protective immunization, to overcome the poor predictive value of non‐clinical in vivo and in vitro models and to drive informed ...
Claudia Teufel +15 more
doaj +1 more source
Advanced Intelligent Systems, EarlyView.This review highlights recent advances in automated iPSC culture systems integrating robotics, advanced imaging, artificial intelligence, and process control. These technologies improve reproducibility, scalability, and quality in cell expansion, differentiation, and real‐time monitoring, while emerging AI‐enabled and closed‐loop approaches offer new ...
Hyoryong Lee +3 more
wiley +1 more source
Microphysiological Systems: A Pathologist\u2019s Perspective
, 2020 Biological systems are complex and difficult to model in vitro. Lack of human-relevant complexity in high throughput reductionist systems undermines confidence in their ability to model in vivo biology and pathologic response.
Sura, Radhakrishna +2 more
core +1 more source
Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip
Frontiers in Cell and Developmental BiologyBackground: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function.
Jae Hee Byeon +5 more
doaj +1 more source