Results 51 to 60 of about 6,641 (226)
Mera: A scalable high throughput automated micro-physiological system
SLAS Technology, 2023 There is an urgent need for scalable Microphysiological Systems (MPS's)11 Microphysiological systems (MPSs), Microtissue (MT), Polyetheretherketone (PEEK), Polytetrafluoroethylene (PTFE), Polystyrene (PS) that can better predict drug efficacy and ...
Finola E. Cliffe +12 more
doaj +1 more source
The Dormancy Dilemma: Quiescence versus Balanced Proliferation [PDF]
, 2013 Metastatic dissemination with subsequent clinical outgrowth leads to the greatest part of morbidity and mortality from most solid tumors. Even more daunting is that many of these metastatic deposits silently lie undetected, recurring years to decades ...
Griffith, Linda G. +3 more
core +2 more sources
CellsInvestigating the mechanisms that maintain different types of neural stem cells is essential for brain development. While factors maintaining distinct Drosophila melanogaster neuroblasts (NBs) have been identified, additional factors remain unidentified.
Qingxia Zhou +6 more
doaj +1 more source
Engineering and monitoring cellular barrier models
Journal of Biological Engineering, 2018 Epithelia and endothelia delineate tissue compartments and control their environments by regulating the passage of ions and solutes. This barrier function is essential for the development and maintenance of multicellular organisms, and its dysfunction is
Jose Yeste +3 more
doaj +1 more source
Augmented 3D Printing for Multiscale Microphysiological Systems. [PDF]
SmallAbstract Microphysiological systems (MPS) can recapitulate physiological features of human organs; however, existing engineering techniques are limited to fabricating sophisticated and functional MPS. Although 3D printing offers the potential to enhance the complexity of MPS and simplify the fabrication process, existing 3D‐printed ...
Hwang KS +7 more
europepmc +4 more sources
Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]
, 2020 Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony +3 more
core +1 more source
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents [PDF]
, 2015 Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied substances
Bauer, Sophie +13 more
core +1 more source
HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease [PDF]
, 2015 Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells.
Bhatia, Sangeeta +3 more
core +1 more source
Microphysiological system design: simplicity is elegance
Current Opinion in Biomedical Engineering, 2020 Design parameters for microphysiological systems (MPS) are driven by the need for new tools to answer questions focusing on human physiology in a robust and reliable manner. Within this perspective, engineering benchmarks and principles are identified to guide the construction of new devices in the MPS field, with emphasis placed on the design ...
Samuel S. Hinman +5 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach +4 more
wiley +1 more source