Results 51 to 60 of about 8,980,611 (179)

Microphysiological Systems: Next Generation Systems for Assessing Toxicity and Therapeutic Effects of Nanomaterials

, 2019
Microphysiological systems, also known as organ-on-a-chip platforms, show promise for the development of new testing methods that can be more accurate than both conventional two-dimensional (2D) cultures and costly animal studies. The development of more
Rumeysa Tutar, Hartel, Martin C., Goudie, Marcus J., Nureddin Ashammakhi, Ali Khademhosseini, Lee, Junmin, Darabi, Mohammad Ali, Saber M. Hussein, Khademhosseini, Ali, Junmin Lee, Mercedes Brianna Cornelius, Cornelius, Mercedes Brianna, Hussein, Saber M., Ashammakhi, Nureddin, Çelebi-Saltik, BETÜL, Mehmet R. Dokmeci, Betül Çelebi‐Saltik, Tutar, Rumeysa, Mohammad Ali Darabi, Martin C. Hartel, Dokmeci, Mehmet R., Marcus J. Goudie   +21 more
core   +1 more source

A functionally tunable magnetic nanochains platform for N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids

Nature Communications
Extracellular vesicles (EVs) carry complex glycoproteins critical mediators of disease progression and hold great potential for liquid biopsy applications. However, their low abundance presents significant analytical challenges.
Mingyang Li, Xiaorong Song, Haixia Tu, Jie Sun, Yuanyuan Deng, Bing Wang, Yuhan Cai, Yulian Wang, Bin Li, Yue Wang, Xiangzheng Zhang, Dong Wei, Xiaoyu Yang, Yueshuai Guo, Xiang Li, Jie Gu, Jie Ni, Yifan Zhou, Zhongze Gu, Zhuoying Xie, Yan Li, Xuejiang Guo   +21 more
doaj   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

Advanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo   +3 more
wiley   +1 more source

Digital Light Processing (DLP)-based 3D printing for microphysiological systems applications [PDF]

, 2022
Tissue engineering encompasses a wide variety of goals, including but not limited to the repair, improvement, or replacement of whole tissues or organs, as well as in vitro investigations of native physiology and functionality. The incorporation of three-
Hwang, Hanjun Henry
core   +1 more source

Microphysiological systems: analysis of the current status, challenges and commercial future [PDF]

, 2018
The field of microphysiological systems (or organs-on-a-chip) experienced, in the past decade, a surge in publications and efforts towards commercialization. Such systems hold the promise to advance drug discovery, diagnostics, and many other areas.
Pawlikowsk, Joanna, Ribas, Joao, Rouwkema, J.   +2 more
core   +1 more source

Microphysiological systems in absorption, distribution, metabolism, and elimination sciences

Clinical and Translational Science, 2022
The use of microphysiological systems (MPS) to support absorption, distribution, metabolism, and elimination (ADME) sciences has grown substantially in the last decade, in part driven by regulatory demands to move away from traditional animal‐based ...
Kirk P. Van Ness, Francine Cesar, Catherine K. Yeung, Jonathan Himmelfarb, Edward J. Kelly   +4 more
doaj   +1 more source

Mera: A scalable high throughput automated micro-physiological system

SLAS Technology, 2023
There is an urgent need for scalable Microphysiological Systems (MPS's)11 Microphysiological systems (MPSs), Microtissue (MT), Polyetheretherketone (PEEK), Polytetrafluoroethylene (PTFE), Polystyrene (PS) that can better predict drug efficacy and ...
Finola E. Cliffe, Conor Madden, Patrick Costello, Shane Devitt, Sumir Ramesh Mukkunda, Bhairavi Bengaluru Keshava, Howard O. Fearnhead, Aiste Vitkauskaite, Mahshid H. Dehkordi, Walter Chingwaru, Milosz Przyjalgowski, Natalia Rebrova, Mark Lyons   +12 more
doaj   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source