Results 51 to 60 of about 4,031 (174)
Cell & BioscienceMost neural stem cells (NSCs) maintain self-renewal to ensure proper development of central nervous system (CNS) until a specific time and undergo terminal differentiation after neurogenesis.
Shuliu Zhang +7 more
doaj +1 more source
Microphysiological systems in absorption, distribution, metabolism, and elimination sciences
Clinical and Translational Science, 2022 The use of microphysiological systems (MPS) to support absorption, distribution, metabolism, and elimination (ADME) sciences has grown substantially in the last decade, in part driven by regulatory demands to move away from traditional animal‐based ...
Kirk P. Van Ness +4 more
doaj +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
Nature CommunicationsExtracellular vesicles (EVs) carry complex glycoproteins critical mediators of disease progression and hold great potential for liquid biopsy applications. However, their low abundance presents significant analytical challenges.
Mingyang Li +21 more
doaj +1 more source
Advanced Science, EarlyView.Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk +9 more
wiley +1 more source
Autologous induced pluripotent stem cell-derived four-organ-chip
Future Science OA, 2019 Microphysiological systems play a pivotal role in progressing toward a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents. All four organ models
Anja Patricia Ramme +17 more
doaj +1 more source
Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
Complex or not too complex? One size does not fit all in next generation microphysiological systems
iScienceSummary: In the attempt to overcome the increasingly recognized shortcomings of existing in vitro and in vivo models, researchers have started to implement alternative models, including microphysiological systems.
Simone Bersini +4 more
doaj +1 more source
Engineering human spinal microphysiological systems to model opioid-induced tolerance
Bioactive Materials, 2023 pioids are commonly used for treating chronic pain. However, with continued use, they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy.
Hongwei Cai +9 more
doaj +1 more source
Super‐Resolution and High‐Data‐Density Acoustic Meta‐Hologram via Amplitude and Phase Coupling
Advanced Science, EarlyView.A super‐resolution acoustic meta‐hologram utilizes amplitude‐phase coupling under energy conservation constraints to overcome the traditional diffraction limit. This conceptually advanced approach achieves high‐fidelity acoustic field reconstruction and dense information transmission, unlocking new potentials for high‐resolution acoustic imaging and ...
Xiao Guo +15 more
wiley +1 more source