Results 51 to 60 of about 4,082 (188)

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

A functionally tunable magnetic nanochains platform for N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids

Nature Communications
Extracellular vesicles (EVs) carry complex glycoproteins critical mediators of disease progression and hold great potential for liquid biopsy applications. However, their low abundance presents significant analytical challenges.
Mingyang Li, Xiaorong Song, Haixia Tu, Jie Sun, Yuanyuan Deng, Bing Wang, Yuhan Cai, Yulian Wang, Bin Li, Yue Wang, Xiangzheng Zhang, Dong Wei, Xiaoyu Yang, Yueshuai Guo, Xiang Li, Jie Gu, Jie Ni, Yifan Zhou, Zhongze Gu, Zhuoying Xie, Yan Li, Xuejiang Guo   +21 more
doaj   +1 more source

Collagen‐Based Gut‐on‐Chip for In Vitro Modeling of Intestinal Barrier Function and Host‐Pathogen Interactions

Advanced Materials Technologies, EarlyView.
A collagen‐based gut‐on‐chip model replicates the intestinal extracellular matrix, supporting villi‐like structures, tight junctions, and mucin production. This biomimetic platform enables rapid epithelial differentiation and functional barrier formation.
Fernanda López García, Jacques Leng, Hugo de Oliveira, Pierre Nassoy, Karine Dementhon   +4 more
wiley   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Complex or not too complex? One size does not fit all in next generation microphysiological systems

iScience
Summary: In the attempt to overcome the increasingly recognized shortcomings of existing in vitro and in vivo models, researchers have started to implement alternative models, including microphysiological systems.
Simone Bersini, Chiara Arrigoni, Giuseppe Talò, Christian Candrian, Matteo Moretti   +4 more
doaj   +1 more source

Microphysiological systems in absorption, distribution, metabolism, and elimination sciences

Clinical and Translational Science, 2022
The use of microphysiological systems (MPS) to support absorption, distribution, metabolism, and elimination (ADME) sciences has grown substantially in the last decade, in part driven by regulatory demands to move away from traditional animal‐based ...
Kirk P. Van Ness, Francine Cesar, Catherine K. Yeung, Jonathan Himmelfarb, Edward J. Kelly   +4 more
doaj   +1 more source

Super‐Resolution and High‐Data‐Density Acoustic Meta‐Hologram via Amplitude and Phase Coupling

Advanced Science, EarlyView.
A super‐resolution acoustic meta‐hologram utilizes amplitude‐phase coupling under energy conservation constraints to overcome the traditional diffraction limit. This conceptually advanced approach achieves high‐fidelity acoustic field reconstruction and dense information transmission, unlocking new potentials for high‐resolution acoustic imaging and ...
Xiao Guo, Xinzong Wang, Guoshen Tang, Haohan Zeng, Siqi Fan, Xinghao Hu, Youyu Mo, Zhenyu He, Tingting Li, Hui Xu, Jiao Shen, Haiyan Fan, Xiaoxiang Gao, Yifan Zhu, Hui Zhang, Badreddine Assouar   +15 more
wiley   +1 more source

Advances of sacrificial strategies in additive manufacturing: towards precision 3D architectures and broad material adaptability

International Journal of Extreme Manufacturing
The pursuit of 3D structures with precise microarchitectures and broad material adaptability has long been a central scientific objective, given their transformative potential to tackle critical challenges across applications such as vascular networks ...
Wenwan Shi, Ming Gao, Xin Zhou, Xiaolu Sun, Haibo Ding, Yuning Zhou, Shuheng Li, Jing Sun, Xiaoxiang Gao, Xiaojiang Liu, Zhongze Gu   +10 more
doaj   +1 more source

The Development of Controllable Magnetic Driven Microphysiological System [PDF]

Frontiers in Cell and Developmental Biology, 2019
Current research has enabled the use of microphysiological systems and creation of models for alveolar and pulmonary diseases. However, bottlenecks remain in terms of medium- and long-term regulation of cell cultures and their functions in microchannel systems, as well as in the enhancement of in vitro representation of alveolar models and reference ...
Jia-Wei Yang, Jia-Wei Yang, Yu-Wei Chen, Pei-Yi Ho, Liane Jiang, Liane Jiang, Kuan Yu Hsieh, Kuan Yu Hsieh, Sheng-Jen Cheng, Sheng-Jen Cheng, Ko-Chih Lin, Ko-Chih Lin, Huai-En Lu, Hsien-Yi Chiu, Hsien-Yi Chiu, Hsien-Yi Chiu, Shien-Fong Lin, Shien-Fong Lin, Guan-Yu Chen, Guan-Yu Chen   +19 more
openaire   +3 more sources