Global Meta-Analysis of Organoid and Organ-on-Chip Research [PDF]
Advanced Healthcare Materials, 2023 Organoids and cells in organ-on-chip platforms replicate higher-level anatomical, physiological, or pathological states of tissues and organs. These technologies are widely regarded by academia, the pharmacological industry and regulators as key ...
Davis, Richard P. +3 more
core +3 more sources
Mimicking the Kidney: A Key Role in Organ-on-Chip Development [PDF]
Micromachines, 2016 Pharmaceutical drug screening and research into diseases call for significant improvement in the effectiveness of current in vitro models. Better models would reduce the likelihood of costly failures at later drug development stages, while limiting or ...
Roberto Paoli, Josep Samitier
doaj +2 more sources
Journey of organ on a chip technology and its role in future healthcare scenario
Applied Surface Science Advances, 2022 Organ on a chip refers to microengineered biomimetic system which reflects structural and functional characteristics of human tissue. It involves biomaterial technology, cell biology and engineering combined together in a miniaturized platform.
Deepanmol Singh +4 more
doaj +3 more sources
A workflow integrating organ-on-chip culture and correlative 3D light and electron microscopy for microtissue analysis [PDF]
Scientific ReportsCorrelative microscopy approaches offer powerful means to study tissue development across spatial scales, but combining 3D light and electron imaging remains technically challenging.
Judith M. Schaart +13 more
doaj +2 more sources
Organ-on-chip technologies: Novel tools with the potential to revolutionize osteoarthritis research and clinical development [PDF]
Osteoarthritis and Cartilage OpenObjective: To critically evaluate the evolution of in vitro models for osteoarthritis (OA) research, with a specific focus on organ-on-chip (OOC) technologies, and to discuss their potential to overcome the limitations of traditional 2D, 3D, and explant ...
Carlo Alberto Paggi
doaj +2 more sources
Organ on Chip Technology to Model Cancer Growth and Metastasis
Bioengineering, 2022 Organ on chip (OOC) has emerged as a major technological breakthrough and distinct model system revolutionizing biomedical research and drug discovery by recapitulating the crucial structural and functional complexity of human organs in vitro.
Giorgia Imparato +2 more
doaj +2 more sources
Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling. [PDF]
J Transl MedHeart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately ...
Liu B +6 more
europepmc +2 more sources
Engineered Vasculature for Organ-on-a-Chip Systems
Engineering, 2022 Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi +8 more
doaj +3 more sources
In vitro immunity: an overview of immunocompetent organ-on-chip models. [PDF]
Front ImmunolImpressive advances have been made to replicate human physiology in vitro over the last few years due to the growth of the organ-on-chip (OoC) field in both industrial and academic settings.
Morrison AI +4 more
europepmc +2 more sources
Organ-on-chip technology: Opportunities and challenges. [PDF]
Biotechnol NotesOrgan-on-chip (OOC) technology is an innovative approach that reproduces human organ structures and functions on microfluidic platforms, offering detailed insights into intricate physiological processes.
Srivastava SK +3 more
europepmc +2 more sources