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Organ on Chip Technology to Model Cancer Growth and Metastasis

Bioengineering, 2022
Organ on chip (OOC) has emerged as a major technological breakthrough and distinct model system revolutionizing biomedical research and drug discovery by recapitulating the crucial structural and functional complexity of human organs in vitro.
Paolo Netti, Giorgia Imparato
exaly   +4 more sources

Journey of organ on a chip technology and its role in future healthcare scenario

Applied Surface Science Advances, 2022
Organ on a chip refers to microengineered biomimetic system which reflects structural and functional characteristics of human tissue. It involves biomaterial technology, cell biology and engineering combined together in a miniaturized platform.
Neeraj Mahindroo, Ashish Mathur, Souradeep Roy   +2 more
exaly   +3 more sources

Organ-on-chip technologies: Novel tools with the potential to revolutionize osteoarthritis research and clinical development [PDF]

Osteoarthritis and Cartilage Open
Objective: To critically evaluate the evolution of in vitro models for osteoarthritis (OA) research, with a specific focus on organ-on-chip (OOC) technologies, and to discuss their potential to overcome the limitations of traditional 2D, 3D, and explant ...
Carlo Alberto Paggi
doaj   +2 more sources

Engineered Vasculature for Organ-on-a-Chip Systems

Engineering, 2022
Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Hongzhao Zhou, Xiaobin Xu, Huayong Yang   +2 more
exaly   +3 more sources

A workflow integrating organ-on-chip culture and correlative 3D light and electron microscopy for microtissue analysis [PDF]

Scientific Reports
Correlative microscopy approaches offer powerful means to study tissue development across spatial scales, but combining 3D light and electron imaging remains technically challenging.
Judith M. Schaart, Dorothee Wasserberg, Marcos A. Eufrásio Cruz, Mariska Kea-te Lindert, Robin H. M. van der Meijden, Rona Roverts, Nataliya Debera, Minh Phu Lu, Jeroen Rouwkema, Wouter H. Nijhuis, Andries D. van der Meer, Pascal Jonkheijm, Nico Sommerdijk, Anat Akiva   +13 more
doaj   +2 more sources

Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling. [PDF]

J Transl Med
Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately ...
Liu B, Wang S, Ma H, Deng Y, Du J, Zhao Y, Chen Y.   +6 more
europepmc   +2 more sources

Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform. [PDF]

Adv Sci (Weinh)
Galactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during missions to the Moon and Mars. Experimental models capable of recapitulating human physiology are critical to understanding the effects of radiation on human ...
Tavakol DN, Nash TR, Kim Y, Graney PL, Liberman M, Fleischer S, Lock RI, O'Donnell A, Andrews L, Ning D, Yeager K, Harken A, Deoli N, Amundson SA, Garty G, Leong KW, Brenner DJ, Vunjak-Novakovic G.   +17 more
europepmc   +2 more sources

Advances in modeling periodontal host-microbe interactions: insights from organotypic and organ-on-chip systems.

Lab Chip
Periodontal disease, a chronic inflammatory condition affecting the supporting structures of teeth, is driven by an imbalanced interaction between the periodontal microbiota and the host inflammatory response. Beyond its local impact, periodontal disease
Makkar H, Sriram G.
europepmc   +2 more sources

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications

Biosensors
Organ-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures due to various limitations of in vivo testing.
Soumya Srivastava, Srivastava Soumya K
exaly   +3 more sources

NeuriTES. Monitoring neurite changes through transfer entropy and semantic segmentation in bright-field time-lapse microscopy

Patterns, 2021
Summary: One of the most challenging frontiers in biological systems understanding is fluorescent label-free imaging. We present here the NeuriTES platform that revisits the standard paradigms of video analysis to detect unlabeled objects and adapt to ...
Arianna Mencattini, Alida Spalloni, Paola Casti, Maria Colomba Comes, Davide Di Giuseppe, Gianni Antonelli, Michele D'Orazio, Joanna Filippi, Francesca Corsi, Hervé Isambert, Corrado Di Natale, Patrizia Longone, Eugenio Martinelli   +12 more
doaj   +1 more source