Results 11 to 20 of about 59,126 (260)
Aggregate, 2023 Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more realistically compared to many animal models and conventional two‐dimensional cell cultures.
Sajjad Rahmani Dabbagh +5 more
doaj +6 more sources
Organs-on-chips: into the next decade [PDF]
Nature Reviews Drug Discovery, 2020 Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue chips' (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process.
Lucie A. Low +4 more
openaire +3 more sources
Human Organs-on-Chips for Virology [PDF]
Trends in Microbiology, 2020 While conventional in vitro culture systems and animal models have been used to study the pathogenesis of viral infections and to facilitate development of vaccines and therapeutics for viral diseases, models that can accurately recapitulate human responses to infection are still lacking.
Tang, H. +6 more
openaire +4 more sources
Organs-on-chip: The way forward [PDF]
Stem Cell Reports, 2021 Organ-on-chip (OoC) technology is thriving thanks to stem cells availability and international OoC programs. Concerted standardization, qualification, and independent testing of devices are needed to coherently develop OoC technology further and fulfill its potential in drug development, disease modeling, and personalized medicine.
Mastrangeli, Massimo +1 more
openaire +4 more sources
Bioprinters for organs-on-chips [PDF]
Biofabrication, 2019 Abstract Recent advances in bioprinting technologies have enabled rapid manufacturing of organ-on-chip models along with biomimetic tissue microarchitectures. Bioprinting techniques can be used to integrate microfluidic channels and flow connections in organ-on-chip models.
Amir K Miri +5 more
openaire +2 more sources
, 2020 Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices.
Tung, Yi-Chung, Torisawa, Yu-suke
openaire +3 more sources
Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro
Micromachines, 2022 Mortality from liver disease conditions continues to be very high. As liver diseases manifest and progress silently, prompt measures after diagnosis are essential in the treatment of these conditions.
Perizat Kanabekova +2 more
doaj +1 more source
Three-Dimensional-Bioprinted Liver Chips and Challenges
Applied Sciences, 2022 Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries ...
Sajjad Rahmani Dabbagh +3 more
doaj +1 more source
Cytostretch, an Organ-on-Chip Platform [PDF]
Micromachines, 2016 Organ-on-Chips (OOCs) are micro-fabricated devices which are used to culture cells in order to mimic functional units of human organs. The devices are designed to simulate the physiological environment of tissues in vivo. Cells in some types of OOCs can be stimulated in situ by electrical and/or mechanical actuators.
Nikolas Gaio +7 more
openaire +7 more sources
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2022 Microfluidic chip systems have been an area of interest for lab-on-a-chip and organ-on-a-chip studies in recent years. These chips have many advantages such as high efficiency, low sample consumption, fast analysis, durability and low cost.
Fatma Doğan Guzel +2 more
doaj +1 more source