Results 11 to 20 of about 68,048 (303)
Oncoimmunology Meets Organs-on-Chip [PDF]
Frontiers in Molecular Biosciences, 2021 Oncoimmunology represents a biomedical research discipline coined to study the roles of immune system in cancer progression with the aim of discovering novel strategies to arm it against the malignancy.
Fabrizio Mattei +8 more
doaj +5 more sources
Aggregate, 2023 Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more realistically compared to many animal models and conventional two‐dimensional cell cultures.
Sajjad Rahmani Dabbagh +5 more
doaj +6 more sources
Organ-on-Chip systems as a model for nanomedicine
Nanoscale, 2023 Nanomedicine is giving rise to increasing numbers of successful drugs, including cancer treatments, molecular imaging agents, and novel vaccine formulations.
M. Stavrou +3 more
semanticscholar +3 more sources
Organs-on-chips: into the next decade [PDF]
Nature Reviews Drug Discovery, 2020 Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue chips' (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process.
Lucie A. Low +4 more
openaire +3 more sources
A directional 3D neurite outgrowth model for studying motor axon biology and disease
Scientific Reports, 2021 We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel,
Xandor M. Spijkers +5 more
doaj +1 more source
Human Organs-on-Chips for Virology [PDF]
Trends in Microbiology, 2020 While conventional in vitro culture systems and animal models have been used to study the pathogenesis of viral infections and to facilitate development of vaccines and therapeutics for viral diseases, models that can accurately recapitulate human responses to infection are still lacking.
Tang, H. +6 more
openaire +4 more sources
Organs-on-chip: The way forward [PDF]
Stem Cell Reports, 2021 Organ-on-chip (OoC) technology is thriving thanks to stem cells availability and international OoC programs. Concerted standardization, qualification, and independent testing of devices are needed to coherently develop OoC technology further and fulfill its potential in drug development, disease modeling, and personalized medicine.
Mastrangeli, Massimo +1 more
openaire +4 more sources
Bioprinters for organs-on-chips [PDF]
Biofabrication, 2019 Abstract Recent advances in bioprinting technologies have enabled rapid manufacturing of organ-on-chip models along with biomimetic tissue microarchitectures. Bioprinting techniques can be used to integrate microfluidic channels and flow connections in organ-on-chip models.
Amir K Miri +5 more
openaire +2 more sources
Bioengineering, 2023 This paper presents an innovative experimental setup that employs the principles of audio technology to subject adherent cells to rhythmic vertical vibrations.
Dongho Kwak +3 more
doaj +1 more source
Micromachines, 2021 The understanding that systemic context and tissue crosstalk are essential keys for bridging the gap between in vitro models and in vivo conditions led to a growing effort in the last decade to develop advanced multi-organ-on-a-chip devices.
Yoel Goldstein +7 more
doaj +1 more source