Results 21 to 30 of about 69,325 (340)
A directional 3D neurite outgrowth model for studying motor axon biology and disease
Scientific Reports, 2021 We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel,
Xandor M. Spijkers +5 more
doaj +1 more source
Organs-on-chip: The way forward [PDF]
Stem Cell Reports, 2021 Organ-on-chip (OoC) technology is thriving thanks to stem cells availability and international OoC programs. Concerted standardization, qualification, and independent testing of devices are needed to coherently develop OoC technology further and fulfill its potential in drug development, disease modeling, and personalized medicine.
Mastrangeli, Massimo +1 more
openaire +4 more sources
Bioengineering, 2023 This paper presents an innovative experimental setup that employs the principles of audio technology to subject adherent cells to rhythmic vertical vibrations.
Dongho Kwak +3 more
doaj +1 more source
Bioprinters for organs-on-chips [PDF]
Biofabrication, 2019 Abstract Recent advances in bioprinting technologies have enabled rapid manufacturing of organ-on-chip models along with biomimetic tissue microarchitectures. Bioprinting techniques can be used to integrate microfluidic channels and flow connections in organ-on-chip models.
Amir K Miri +5 more
openaire +2 more sources
Micromachines, 2021 The understanding that systemic context and tissue crosstalk are essential keys for bridging the gap between in vitro models and in vivo conditions led to a growing effort in the last decade to develop advanced multi-organ-on-a-chip devices.
Yoel Goldstein +7 more
doaj +1 more source
Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment [PDF]
, 2016 Organs-on-chips are three-dimensional, microfluidic cell culture systems that simulate the function of tissues and organ subunits. Organ-on-chip systems are expected to contribute to drug candidate screening and the reduction of animal tests in ...
Hummel, J. Marjan +6 more
core +6 more sources
Human Organs-on-Chips for Virology [PDF]
Trends in Microbiology, 2020 While conventional in vitro culture systems and animal models have been used to study the pathogenesis of viral infections and to facilitate development of vaccines and therapeutics for viral diseases, models that can accurately recapitulate human responses to infection are still lacking.
Tang, H. +6 more
openaire +4 more sources
, 2020 Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices.
Tung, Yi-Chung, Torisawa, Yu-suke
openaire +3 more sources
ACS Biomaterials Science & Engineering, 2021 Organ-on-chip systems are promising new in vitro research tools in medical, pharmaceutical, and biological research. Their main benefit, compared to standard cell culture platforms, lies in the improved in vivo resemblance of the cell culture environment.
Stefanie Fuchs +5 more
semanticscholar +1 more source
Bioengineering, 2022 Developing novel drug formulations and progressing them to the clinical environment relies on preclinical in vitro studies and animal tests to evaluate efficacy and toxicity.
Hanieh Gholizadeh +6 more
doaj +1 more source