Results 21 to 30 of about 68,048 (303)
ACS Biomaterials Science & Engineering, 2021 Organ-on-chip systems are promising new in vitro research tools in medical, pharmaceutical, and biological research. Their main benefit, compared to standard cell culture platforms, lies in the improved in vivo resemblance of the cell culture environment.
Stefanie Fuchs +5 more
semanticscholar +1 more source
Integration of Extracellular Matrices into Organ‐on‐Chip Systems
Advanced Healthcare Materials, 2023 The extracellular matrix (ECM) is a complex, dynamic network present within all tissues and organs that not only acts as a mechanical support and anchorage point but can also direct fundamental cell behavior, function, and characteristics.
Hazal Kutluk +2 more
semanticscholar +1 more source
, 2020 Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices.
Tung, Yi-Chung, Torisawa, Yu-suke
openaire +3 more sources
Bioengineering, 2022 Developing novel drug formulations and progressing them to the clinical environment relies on preclinical in vitro studies and animal tests to evaluate efficacy and toxicity.
Hanieh Gholizadeh +6 more
doaj +1 more source
Three-Dimensional-Bioprinted Liver Chips and Challenges
Applied Sciences, 2022 Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries ...
Sajjad Rahmani Dabbagh +3 more
doaj +1 more source
Lab on a Chip, 2021 Drug development suffers from a lack of predictive and human-relevant in vitro models. Organ-on-chip (OOC) technology provides advanced culture capabilities to generate physiologically appropriate, human-based tissue in vitro, therefore providing a route
H. Azizgolshani +27 more
semanticscholar +1 more source
Cytostretch, an Organ-on-Chip Platform [PDF]
Micromachines, 2016 Organ-on-Chips (OOCs) are micro-fabricated devices which are used to culture cells in order to mimic functional units of human organs. The devices are designed to simulate the physiological environment of tissues in vivo. Cells in some types of OOCs can be stimulated in situ by electrical and/or mechanical actuators.
Nikolas Gaio +7 more
openaire +7 more sources
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2022 Microfluidic chip systems have been an area of interest for lab-on-a-chip and organ-on-a-chip studies in recent years. These chips have many advantages such as high efficiency, low sample consumption, fast analysis, durability and low cost.
Fatma Doğan Guzel +2 more
doaj +1 more source
3D multicellular systems in disease modelling: From organoids to organ-on-chip
Frontiers in Cell and Developmental Biology, 2023 Cell-cell interactions underlay organ formation and function during homeostasis. Changes in communication between cells and their surrounding microenvironment are a feature of numerous human diseases, including metabolic disease and neurological ...
Caoimhe Goldrick +6 more
semanticscholar +1 more source
Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro
Micromachines, 2022 Mortality from liver disease conditions continues to be very high. As liver diseases manifest and progress silently, prompt measures after diagnosis are essential in the treatment of these conditions.
Perizat Kanabekova +2 more
doaj +1 more source