Results 21 to 30 of about 59,126 (260)
Modular Microphysiological System for Modeling of Biologic Barrier Function
Frontiers in Bioengineering and Biotechnology, 2020 Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,
Matthew Ishahak +10 more
doaj +1 more source
Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery
Pharmaceutics, 2023 Drug discovery is an expensive, long, and complex process, usually with a high degree of uncertainty. In order to improve the efficiency of drug development, effective methods are demanded to screen lead molecules and eliminate toxic compounds in the ...
Jingyu Fu, Hailong Qiu, Cherie S. Tan
doaj +1 more source
Emergence of microfluidics for next generation biomedical devices
Biosensors and Bioelectronics: X, 2022 The attention in lab-on-a-chip devices with their potent application in medical engineering has prolonged swiftly over the last ten years. Travelling through the technology development, innovative microfluidics devices shown enormous potential to lift ...
Subham Preetam +7 more
doaj +1 more source
Organ-on-Chip In Development:Towards a roadmap for Organs-on-Chip
ALTEX, 2019 Organ-on-Chip is a game-changing technology born from the convergence of tissue engineering and microfluidic technology. Organ-on-Chip devices (OoCs) are expected to offer effective solutions to persisting problems in drug development and personalized disease treatments.
M. Mastrangeli +3 more
openaire +6 more sources
Micromachines, 2021 Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun +4 more
doaj +1 more source
Organs-on-chips: a decade of innovation
Trends in Biotechnology, 2023 Recreating 'living organs' with groundbreaking organ-on-a-chip (OOC) technologies is facilitating a new era of drug discovery. Studies by Huh et al. and Ronaldson-Bouchard et al. underscore advances made over a decade, spanning single organ functionality to interconnected organs, that enable examination of drug toxicities and disease pathogenesis in ...
Carly Strelez +2 more
openaire +2 more sources
Open Research Europe, 2023 It is difficult to model in vitro the intestine when seeking to include crosstalk with the gut microbiota, immune and neuroendocrine systems. Here we present a roadmap of the current models to facilitate the choice in preclinical and translational ...
Giulia Malaguarnera +2 more
doaj +1 more source
Recent advances in vascularized tumor-on-a-chip
Frontiers in Oncology, 2023 The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of ...
Christina Bao Xian Huang +3 more
doaj +1 more source
Microfluidic Gut-on-a-Chip: Fundamentals and Challenges
Biosensors, 2023 The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs.
Dimple Palanilkunnathil Thomas +3 more
doaj +1 more source
3D Printing of Organs-On-Chips [PDF]
Bioengineering, 2017 Organ-on-a-chip engineering aims to create artificial living organs that mimic the complex and physiological responses of real organs, in order to test drugs by precisely manipulating the cells and their microenvironments. To achieve this, the artificial organs should to be microfabricated with an extracellular matrix (ECM) and various types of cells ...
YI, HEE GYEONG +2 more
openaire +4 more sources