Results 31 to 40 of about 69,325 (340)
Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro
Micromachines, 2022 Mortality from liver disease conditions continues to be very high. As liver diseases manifest and progress silently, prompt measures after diagnosis are essential in the treatment of these conditions.
Perizat Kanabekova +2 more
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Integration of Extracellular Matrices into Organ‐on‐Chip Systems
Advanced Healthcare Materials, 2023 The extracellular matrix (ECM) is a complex, dynamic network present within all tissues and organs that not only acts as a mechanical support and anchorage point but can also direct fundamental cell behavior, function, and characteristics.
Hazal Kutluk +2 more
semanticscholar +1 more source
Three-Dimensional-Bioprinted Liver Chips and Challenges
Applied Sciences, 2022 Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries ...
Sajjad Rahmani Dabbagh +3 more
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Lab on a Chip, 2021 Drug development suffers from a lack of predictive and human-relevant in vitro models. Organ-on-chip (OOC) technology provides advanced culture capabilities to generate physiologically appropriate, human-based tissue in vitro, therefore providing a route
H. Azizgolshani +27 more
semanticscholar +1 more source
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2022 Microfluidic chip systems have been an area of interest for lab-on-a-chip and organ-on-a-chip studies in recent years. These chips have many advantages such as high efficiency, low sample consumption, fast analysis, durability and low cost.
Fatma Doğan Guzel +2 more
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Frontiers in Pharmacology, 2023 The inefficiency of existing animal models to precisely predict human pharmacological effects is the root reason for drug development failure. Microphysiological system/organ-on-a-chip technology (organ-on-a-chip platform) is a microfluidic device ...
Naina Sunildutt +4 more
semanticscholar +1 more source
Diffusive Molecular Communication with a Spheroidal Receiver for Organ-on-Chip Systems [PDF]
ICC 2023 - IEEE International Conference on Communications, 2023 Realistic models of the components and processes are required for molecular communication (MC) systems. In this paper, a spheroidal receiver structure is proposed for MC that is inspired by the 3D cell cultures known as spheroids being widely used in ...
Hamidreza Arjmandi +7 more
semanticscholar +1 more source
Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery
Pharmaceutics, 2023 Drug discovery is an expensive, long, and complex process, usually with a high degree of uncertainty. In order to improve the efficiency of drug development, effective methods are demanded to screen lead molecules and eliminate toxic compounds in the ...
Jingyu Fu, Hailong Qiu, Cherie S. Tan
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Emergence of microfluidics for next generation biomedical devices
Biosensors and Bioelectronics: X, 2022 The attention in lab-on-a-chip devices with their potent application in medical engineering has prolonged swiftly over the last ten years. Travelling through the technology development, innovative microfluidics devices shown enormous potential to lift ...
Subham Preetam +7 more
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3D multicellular systems in disease modelling: From organoids to organ-on-chip
Frontiers in Cell and Developmental Biology, 2023 Cell-cell interactions underlay organ formation and function during homeostasis. Changes in communication between cells and their surrounding microenvironment are a feature of numerous human diseases, including metabolic disease and neurological ...
Caoimhe Goldrick +6 more
semanticscholar +1 more source