Results 31 to 40 of about 59,126 (260)

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

Frontiers in Bioengineering and Biotechnology, 2023
Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is
Cristian F. Rodríguez, Valentina Andrade-Pérez, María Camila Vargas, Andrés Mantilla-Orozco, Johann F. Osma, Luis H. Reyes, Juan C. Cruz   +6 more
doaj   +1 more source

Microelectromechanical Organs-on-Chip

2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), 2021
Stemming from the convergence of tissue engineering and microfluidics, organ-on-chip (OoC) technology can reproduce in vivo-like dynamic microphysiological environments for tissues in vitro. The possibility afforded by OoC devices of realistic recapitulation of tissue and organ (patho)physiology may hold the key to bridge the current translational gap ...
Mastrangeli, Massimo (author), Aydogmus, H. (author), Dostanic, M. (author), Motreuil-Ragot, P.A. (author), Revyn, N. (author), de Wagenaar, B. (author), Dekker, R. (author), Sarro, Pasqualina M (author)   +7 more
openaire   +3 more sources

Physiologically relevant organs on chips [PDF]

Biotechnology Journal, 2013
AbstractRecent advances in integrating microengineering and tissue engineering have generated promising microengineered physiological models for experimental medicine and pharmaceutical research. Here we review the recent development of microengineered physiological systems, or also known as “ogans‐on‐chips”, that reconstitute the physiologically ...
Kyungsuk, Yum, Soon Gweon, Hong, Kevin E, Healy, Luke P, Lee   +3 more
openaire   +2 more sources

Microfluidic Platforms to Unravel Mysteries of Alzheimer’s Disease: How Far Have We Come?

Life, 2021
Alzheimer’s disease (AD) is a significant health concern with enormous social and economic impact globally. The gradual deterioration of cognitive functions and irreversible neuronal losses are primary features of the disease.
Pragya Prasanna, Shweta Rathee, Vedanabhatla Rahul, Debabrata Mandal, Macherla Sharath Chandra Goud, Pardeep Yadav, Susan Hawthorne, Ankur Sharma, Piyush Kumar Gupta, Shreesh Ojha, Niraj Kumar Jha, Chiara Villa, Saurabh Kumar Jha   +12 more
doaj   +1 more source

Organs-on-Chips

Current Opinion in Toxicology, 2019
Blood hypercoagulability and thrombosis have been observed in patients during clinical trials of candidate drugs, yet these safety risks are seldom identified during preclinical testing, leading to increased mortality and morbidity, and increased attrition rates in the clinic.
Yunki Lee, Song Ih Ahn, YongTae Kim
openaire   +2 more sources

Guiding organs-on-chips towards applications: a balancing act between integration of advanced technologies and standardization

Frontiers in Lab on a Chip Technologies
Organs-on-chips (OoC) are in vitro models that emulate key functionalities of tissues or organs in a miniaturized and highly controlled manner. Due to their high versatility, OoC have evolved as promising alternatives to animal testing for a more ...
J. Meneses, F. Conceição, A. D. van der Meer, A. D. van der Meer, S. de Wit, L. Moreira Teixeira, L. Moreira Teixeira   +6 more
doaj   +1 more source

Cells in the 3D biomatrix on-chip: better mimicking the real micro-physiological system

Next Materials
Recent advances in microfluidic technology and biomaterial science have augmented the use of organ-on-chip (OoC) technology to closely mimic the human pathophysiology.
Michele D’Orazio, Joanna Filippi, Gianni Antonelli, Giorgia Curci, Paola Casti, Arianna Mencattini, Gianluca Cidonio, Eugenio Martinelli   +7 more
doaj   +1 more source

Organ on Chip Technology to Model Cancer Growth and Metastasis

Bioengineering, 2022
Organ on chip (OOC) has emerged as a major technological breakthrough and distinct model system revolutionizing biomedical research and drug discovery by recapitulating the crucial structural and functional complexity of human organs in vitro.
Giorgia Imparato, Francesco Urciuolo, Paolo Antonio Netti   +2 more
doaj   +1 more source

Organs-on-chips: latest developments

Microphysiological Systems, 2019
Welcome to the collection of the current must-read open-access papers in the field of organs-on-chips that have become available in the second half of 2018. This quarterly editorial column will be compiled by Dr. Andries D. van der Meer, University of Twente, The Netherlands.
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source