Results 31 to 40 of about 68,048 (303)
Frontiers in Pharmacology, 2023 The inefficiency of existing animal models to precisely predict human pharmacological effects is the root reason for drug development failure. Microphysiological system/organ-on-a-chip technology (organ-on-a-chip platform) is a microfluidic device ...
Naina Sunildutt +4 more
semanticscholar +1 more source
Modular Microphysiological System for Modeling of Biologic Barrier Function
Frontiers in Bioengineering and Biotechnology, 2020 Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,
Matthew Ishahak +10 more
doaj +1 more source
Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery
Pharmaceutics, 2023 Drug discovery is an expensive, long, and complex process, usually with a high degree of uncertainty. In order to improve the efficiency of drug development, effective methods are demanded to screen lead molecules and eliminate toxic compounds in the ...
Jingyu Fu, Hailong Qiu, Cherie S. Tan
doaj +1 more source
Global Literature Analysis of Organoid and Organ‐on‐Chip Research
Advanced Healthcare Materials, 2023 Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical, physiological, or pathological states of tissues and organs. These technologies are widely regarded by academia, the pharmacological industry and regulators as key ...
Jun-Ya Shoji +3 more
semanticscholar +1 more source
Organ-on-Chip In Development:Towards a roadmap for Organs-on-Chip
ALTEX, 2019 Organ-on-Chip is a game-changing technology born from the convergence of tissue engineering and microfluidic technology. Organ-on-Chip devices (OoCs) are expected to offer effective solutions to persisting problems in drug development and personalized disease treatments.
M. Mastrangeli +3 more
openaire +6 more sources
Emergence of microfluidics for next generation biomedical devices
Biosensors and Bioelectronics: X, 2022 The attention in lab-on-a-chip devices with their potent application in medical engineering has prolonged swiftly over the last ten years. Travelling through the technology development, innovative microfluidics devices shown enormous potential to lift ...
Subham Preetam +7 more
doaj +1 more source
An organ-on-chip device with integrated charge sensors and recording microelectrodes
Scientific Reports, 2023 Continuous monitoring of tissue microphysiology is a key enabling feature of the organ-on-chip (OoC) approach for in vitro drug screening and disease modeling.
H. Aydogmus +6 more
semanticscholar +1 more source
Diffusive Molecular Communication with a Spheroidal Receiver for Organ-on-Chip Systems [PDF]
ICC 2023 - IEEE International Conference on Communications, 2023 Realistic models of the components and processes are required for molecular communication (MC) systems. In this paper, a spheroidal receiver structure is proposed for MC that is inspired by the 3D cell cultures known as spheroids being widely used in ...
Hamidreza Arjmandi +7 more
semanticscholar +1 more source
Micromachines, 2021 Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun +4 more
doaj +1 more source
Organs-on-chips: a decade of innovation
Trends in Biotechnology, 2023 Recreating 'living organs' with groundbreaking organ-on-a-chip (OOC) technologies is facilitating a new era of drug discovery. Studies by Huh et al. and Ronaldson-Bouchard et al. underscore advances made over a decade, spanning single organ functionality to interconnected organs, that enable examination of drug toxicities and disease pathogenesis in ...
Carly Strelez +2 more
openaire +2 more sources