Results 51 to 60 of about 67,848,505 (299)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications

, 2019
Organ-on-chips are miniaturised devices aiming at replacing animal models for drug discovery, toxicology and studies of complex biological phenomena. The field of Organ-On-Chip has grown exponentially, and has led to the formation of companies providing ...
Arianna Mencatti, Alfredo E. Ongaro, Lina Ghibelli, Vanessa Mancini, Vicki Stone, Maïwenn Kersaudy-Kerhoas, MaÃwenn Kersaudy-Kerhoas, Virginia Pensabene, Allende Miguelez Crespo, Krystian L. Wlodarczyk, Duncan P. Hand, Nicola Howarth, Davide Di Giuseppe, Vincenzo La Carrubba, Ali Kermanizadeh, Eugenio Martinelli   +15 more
core   +1 more source

Organs-on-chips: latest developments

Microphysiological Systems, 2019
Welcome to the collection of the current must-read open-access papers in the field of organs-on-chips that have become available in the second half of 2018. This quarterly editorial column will be compiled by Dr. Andries D. van der Meer, University of Twente, The Netherlands.
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Organ on Chip Technology to Model Cancer Growth and Metastasis

Bioengineering, 2022
Organ on chip (OOC) has emerged as a major technological breakthrough and distinct model system revolutionizing biomedical research and drug discovery by recapitulating the crucial structural and functional complexity of human organs in vitro.
Giorgia Imparato, Francesco Urciuolo, Paolo Antonio Netti   +2 more
doaj   +1 more source

Supplementary material. Autologous iPSC-derived four-organ-chip

, 2019
Supplementary material. Autologous iPSC-derived four-organ-chipMicrophysiological systems play a pivotal role in progressing towards a global paradigm shift in drug development.
Lin, Grace (7363457), Grabovica, Alexandra (7363454), Hasenberg, Tobias (7363430), Pabinger, Stephan (7363460), Lauster, Roland (7363466), Drewell, Christopher (7363448), Lorenz, Alexandra (7363442), Schwenk, Christine (7363433), Magauer, Corinna (7363436), Neuhaus, Winfried (7363463), Bois, Frederic (5776781), Schirrmann, Kerstin (7363451), Ramme, Anja (7363424), Faust, Daniel (7363439), Marx, Uwe (7363469), Dehne, Eva-Maria (7363472), Koenig, Leopold (7363427), Krebs, Anna (7363445)   +17 more
core   +1 more source

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

, 2022
S.3538-3547Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, to accurately predict drug toxicity.
Lauster, R., Tonevitsky, A.G., Sakharov, D.A., Süßbier, U., Trushkin, E.V., Sonntag, F., Frädrich, C., Brincker, S., Busek, M., Wagner, I., Marx, U., Materne, E.-M.   +11 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Fabrication of continuous iron wire reinforced poly-L-lactic acid (PLLA) filaments for producing biodegradable stents via a braiding process

Results in Engineering
Poly-L-lactic acid (PLLA) is widely used in medical applications due to its excellent biodegradability and biocompatibility. However, its limited mechanical strength poses challenges for applications like biodegradable stents, which require both strength
Yuanyuan Chen, Handai Liu, Emma J. Murphy, Gustavo Waltzer Fehrenbach, Tielidy Angelina De Morais De Lima, Dhanyamol George, Niall Burke, Aiden Flannagan   +7 more
doaj   +1 more source

Graphical Abstract. Autologous iPSC-derived four-organ-chip

, 2019
Microphysiological systems play a pivotal role in progressing towards a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents.
Lin, Grace (7363457), Grabovica, Alexandra (7363454), Hasenberg, Tobias (7363430), Pabinger, Stephan (7363460), Lauster, Roland (7363466), Drewell, Christopher (7363448), Lorenz, Alexandra (7363442), Schwenk, Christine (7363433), Magauer, Corinna (7363436), Neuhaus, Winfried (7363463), Bois, Frederic (5776781), Schirrmann, Kerstin (7363451), Ramme, Anja (7363424), Faust, Daniel (7363439), Marx, Uwe (7363469), Dehne, Eva-Maria (7363472), Koenig, Leopold (7363427), Krebs, Anna (7363445)   +17 more
core   +1 more source