Results 51 to 60 of about 68,048 (303)
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures.
Lab on a Chip, 2021 Three-dimensional cell cultures using patient-derived stem cells are essential in vitro models for a more efficient and individualized cancer therapy.
Johannes Dornhof +5 more
semanticscholar +1 more source
Advancement of Sensor Integrated Organ-on-Chip Devices
Italian National Conference on Sensors, 2021 Organ-on-chip devices have provided the pharmaceutical and tissue engineering worlds much hope since they arrived and began to grow in sophistication. However, limitations for their applicability were soon realized as they lacked real-time monitoring and
Gabriel A. Clarke +10 more
semanticscholar +1 more source
Basement membrane properties and their recapitulation in organ-on-chip applications
Materials Today Bio, 2022 Drug discovery and toxicology is a complex process that involves considerable basic research and preclinical evaluation. These depend highly on animal testing which often fails to predict human trial outcomes due to species differences.
G. Salimbeigi +4 more
semanticscholar +1 more source
Developer’s Guide to an Organ-on-Chip Model
ACS Biomaterials Science & Engineering, 2022 Over the past decade, organ-on-chip research has been one of the most prolific areas of the entire field of tissue engineering. The development of organ-on-chip models requires an integrated interdisciplinary approach merging technologies and concepts ...
Julia Rogal +2 more
semanticscholar +1 more source
Current Opinion in Toxicology, 2019 Blood hypercoagulability and thrombosis have been observed in patients during clinical trials of candidate drugs, yet these safety risks are seldom identified during preclinical testing, leading to increased mortality and morbidity, and increased attrition rates in the clinic.
Yunki Lee, Song Ih Ahn, YongTae Kim
openaire +2 more sources
Microelectromechanical Organs-on-Chip
2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), 2021 Stemming from the convergence of tissue engineering and microfluidics, organ-on-chip (OoC) technology can reproduce in vivo-like dynamic microphysiological environments for tissues in vitro. The possibility afforded by OoC devices of realistic recapitulation of tissue and organ (patho)physiology may hold the key to bridge the current translational gap ...
Mastrangeli, Massimo (author) +7 more
openaire +3 more sources
Microfluidic Platforms to Unravel Mysteries of Alzheimer’s Disease: How Far Have We Come?
Life, 2021 Alzheimer’s disease (AD) is a significant health concern with enormous social and economic impact globally. The gradual deterioration of cognitive functions and irreversible neuronal losses are primary features of the disease.
Pragya Prasanna +12 more
doaj +1 more source
Drug Discovery TodayArtificial intelligence (AI) is reshaping preclinical drug research offering innovative alternatives to traditional animal testing. Advanced techniques, including machine learning (ML), deep learning (DL), AI-powered digital twins (DTs), and AI-enhanced ...
Amit Gangwal, Antonio Lavecchia
semanticscholar +1 more source
Liver organ-on-chip models for toxicity studies and risk assessment.
Lab on a Chip, 2022 The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of functions in the body, including homeostasis, synthesis of essential components, nutrient storage, and detoxification.
Taha Messelmani +6 more
semanticscholar +1 more source
Physiologically relevant organs on chips [PDF]
Biotechnology Journal, 2013 AbstractRecent advances in integrating microengineering and tissue engineering have generated promising microengineered physiological models for experimental medicine and pharmaceutical research. Here we review the recent development of microengineered physiological systems, or also known as “ogans‐on‐chips”, that reconstitute the physiologically ...
Kyungsuk, Yum +3 more
openaire +2 more sources