Results 51 to 60 of about 59,126 (260)

Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

Bioactive Materials, 2021
Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental exposure.
Rick Xing Ze Lu, Milica Radisic
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Developer’s Guide to an Organ-on-Chip Model

ACS Biomaterials Science & Engineering, 2022
Over the past decade, organ-on-chip research has been one of the most prolific areas of the entire field of tissue engineering. The development of organ-on-chip models requires an integrated interdisciplinary approach merging technologies and concepts from several different disciplines, including microfabrication, microfluidics, biomaterials, stem cell
Julia Rogal, Katharina Schlünder, Peter Loskill   +2 more
openaire   +2 more sources

Mimicking and surpassing the xenograft model with cancer-on-chip technology

EBioMedicine, 2021
Organs-on-chips are in vitro models in which human tissues are cultured in microfluidic compartments with a controlled, dynamic micro-environment. Specific organs-on-chips are being developed to mimic human tumors, but the validation of such ‘cancer-on ...
Job Komen, Sanne M. van Neerven, Albert van den Berg, Louis Vermeulen, Andries D. van der Meer   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Organs-on-chips

Nature Reviews Drug Discovery, 2021
Organs-on-chips (OoCs), also known as microphysiological systems or ‘tissue chips’ (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process.
Low, Lucie A., Mummery, Christine, Berridge, Brian R., Austin, Christopher P., Tagle, Danilo A.   +4 more
openaire   +1 more source

Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects

Biomedicines
Background/Objectives: Liver-on-a-chip (LiOC) technology is increasingly recognized as a transformative platform for modeling liver biology, disease mechanisms, drug metabolism, and toxicity screening.
Joseph Mugaanyi, Jing Huang, Jiongze Fang, Arthur Musinguzi, Caide Lu, Zaozao Chen   +5 more
doaj   +1 more source

Early prediction of neoadjuvant chemotherapy response by exploiting a transfer learning approach on breast DCE-MRIs

Scientific Reports, 2021
The dynamic contrast-enhanced MR imaging plays a crucial role in evaluating the effectiveness of neoadjuvant chemotherapy (NAC) even since its early stage through the prediction of the final pathological complete response (pCR).
Maria Colomba Comes, Annarita Fanizzi, Samantha Bove, Vittorio Didonna, Sergio Diotaiuti, Daniele La Forgia, Agnese Latorre, Eugenio Martinelli, Arianna Mencattini, Annalisa Nardone, Angelo Virgilio Paradiso, Cosmo Maurizio Ressa, Pasquale Tamborra, Vito Lorusso, Raffaella Massafra   +14 more
doaj   +1 more source

Bioprinting of Organ-on-Chip Systems: A Literature Review from a Manufacturing Perspective

Journal of Manufacturing and Materials Processing, 2021
This review discusses the reported studies investigating the use of bioprinting to develop functional organ-on-chip systems from a manufacturing perspective.
Ketan Thakare, Laura Jerpseth, Zhijian Pei, Alaa Elwany, Francis Quek, Hongmin Qin   +5 more
doaj   +1 more source