Results 71 to 80 of about 68,048 (303)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

In vitro immunity: an overview of immunocompetent organ-on-chip models

Frontiers in Immunology
Impressive advances have been made to replicate human physiology in vitro over the last few years due to the growth of the organ-on-chip (OoC) field in both industrial and academic settings.
Andrew I. Morrison, Mirthe J. Sjoerds, Leander A. Vonk, Susan Gibbs, Jasper J. Koning   +4 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Organs-on-chips

Nature Reviews Drug Discovery, 2021
Organs-on-chips (OoCs), also known as microphysiological systems or ‘tissue chips’ (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process.
Low, Lucie A., Mummery, Christine, Berridge, Brian R., Austin, Christopher P., Tagle, Danilo A.   +4 more
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Fabrication of continuous iron wire reinforced poly-L-lactic acid (PLLA) filaments for producing biodegradable stents via a braiding process

Results in Engineering
Poly-L-lactic acid (PLLA) is widely used in medical applications due to its excellent biodegradability and biocompatibility. However, its limited mechanical strength poses challenges for applications like biodegradable stents, which require both strength
Yuanyuan Chen, Handai Liu, Emma J. Murphy, Gustavo Waltzer Fehrenbach, Tielidy Angelina De Morais De Lima, Dhanyamol George, Niall Burke, Aiden Flannagan   +7 more
doaj   +1 more source

Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery

Frontiers in Bioengineering and Biotechnology, 2022
Human Microphysiological Systems (hMPS), otherwise known as organ- and tissue-on-a-chip models, are an emerging technology with the potential to replace in vivo animal studies with in vitro models that emulate human physiology at basic levels.
Raquel E. Ajalik, Raquel E. Ajalik, Rahul G. Alenchery, Rahul G. Alenchery, John S. Cognetti, Victor Z. Zhang, Victor Z. Zhang, James L. McGrath, Benjamin L. Miller, Benjamin L. Miller, Hani A. Awad, Hani A. Awad   +11 more
doaj   +1 more source

Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models

Frontiers in Bioengineering and Biotechnology, 2020
Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and disease hold great promise for improving fundamental research, drug ...
C. Thompson, S. Fu, H. K. Heywood, M. Knight, S. Thorpe   +4 more
semanticscholar   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Pump‐Less, Recirculating Organ‐on‐Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver

Advanced Healthcare Materials
Type 2 diabetes mellitus (T2DM), obesity, and metabolic dysfunction‐associated steatotic liver disease (MASLD) are epidemiologically correlated disorders with a worldwide growing prevalence.
Aleksandra Aizenshtadt, Chencheng Wang, Shadab Abadpour, Pedro Duarte Menezes, Ingrid Wilhelmsen, Andrea Dalmao-Fernandez, Justyna Stokowiec, Alexey Golovin, M. Johnsen, T. Combriat, H. Røberg-Larsen, Nikolaj Gadegaard, Hanne Scholz, Mathias Busek, Stephan J K Krauss   +14 more
semanticscholar   +1 more source