Results 71 to 80 of about 67,848,505 (299)

Bioprinting of Organ-on-Chip Systems: A Literature Review from a Manufacturing Perspective

Journal of Manufacturing and Materials Processing, 2021
This review discusses the reported studies investigating the use of bioprinting to develop functional organ-on-chip systems from a manufacturing perspective.
Ketan Thakare, Laura Jerpseth, Zhijian Pei, Alaa Elwany, Francis Quek, Hongmin Qin   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Development of Organ-on-Chip for the Study of Placental Pathologies: A Ten-Year Study of Literature Published

Health Technology Assessment in Action, 2023
Context: The placenta performs a crucial function in nutrient exchange, but studying this tissue poses a number of challenges. Utilizing microfluidic and microfabrication technologies, a 3D placenta-on-a-chip model provides a biomimetic alternative for ...
Ravindra Kalode, Pranoti Kalode
doaj   +1 more source

Multistep Fluidic Control Network toward the Automated Generation of Organ-on-a-Chip

, 2019
Organ-on-a-chip, which mimics physiological functions of organs, is a potential tool for drug development and precision medicine. This chip, accompanied by a suitable culture environment and appropriate culture procedure, allows cells to form functional ...
Jen-Huang Huang, Jen-Huang Huang (452919), Pulak Nath, Pulak Nath (2400136), Hsin-Lin Hsieh, Hsin-Lin Hsieh (7115480)   +5 more
core   +1 more source

The Role of Microfluidics for Organ on Chip Simulations [PDF]

Bioengineering, 2017
A multichannel three-dimensional chip of a microfluidic cell culture which enables the simulation of organs is called an “organ on a chip” (OC). With the integration of many other technologies, OCs have been mimicking organs, substituting animal models, and diminishing the time and cost of experiments which is better than the preceding conventional in ...
Aziz, Aziz Ur Rehman, Geng, Chunyang, Fu, Mengjie, Yu, Xiaohui, Qin, Kairong, Liu, Bo   +5 more
openaire   +2 more sources

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects

Biomedicines
Background/Objectives: Liver-on-a-chip (LiOC) technology is increasingly recognized as a transformative platform for modeling liver biology, disease mechanisms, drug metabolism, and toxicity screening.
Joseph Mugaanyi, Jing Huang, Jiongze Fang, Arthur Musinguzi, Caide Lu, Zaozao Chen   +5 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Early prediction of neoadjuvant chemotherapy response by exploiting a transfer learning approach on breast DCE-MRIs

Scientific Reports, 2021
The dynamic contrast-enhanced MR imaging plays a crucial role in evaluating the effectiveness of neoadjuvant chemotherapy (NAC) even since its early stage through the prediction of the final pathological complete response (pCR).
Maria Colomba Comes, Annarita Fanizzi, Samantha Bove, Vittorio Didonna, Sergio Diotaiuti, Daniele La Forgia, Agnese Latorre, Eugenio Martinelli, Arianna Mencattini, Annalisa Nardone, Angelo Virgilio Paradiso, Cosmo Maurizio Ressa, Pasquale Tamborra, Vito Lorusso, Raffaella Massafra   +14 more
doaj   +1 more source

Low-cost on-chip clock jitter measurement scheme [PDF]

, 2014
In this paper, we present a low-cost, on-chip clock jitter digital measurement scheme for high performance microprocessors. It enables in situ jitter measurement during the test or debug phase.
Giaffreda, Daniele, Rahman A., Omana, Martin, Rossi D., Tam, S., Omana M., Omana, M., Metra C., Metra, C., Mak, TM, Rahman, A., Rossi, Daniele, S. Tam, Giaffreda, D., Metra, Cecilia, Raman, Asifur, A. Rahman, Mak, T.M., Mak T. M., D. Giaffreda, TM Mak, Giaffreda D., Tam, Simon, Tam S., OMANA, MARTIN EUGENIO, Rossi, D.   +25 more
core   +1 more source