Results 81 to 90 of about 69,325 (340)

Guiding organs-on-chips towards applications: a balancing act between integration of advanced technologies and standardization

Frontiers in Lab on a Chip Technologies
Organs-on-chips (OoC) are in vitro models that emulate key functionalities of tissues or organs in a miniaturized and highly controlled manner. Due to their high versatility, OoC have evolved as promising alternatives to animal testing for a more ...
J. Meneses, F. Conceição, A. D. van der Meer, A. D. van der Meer, S. de Wit, L. Moreira Teixeira, L. Moreira Teixeira   +6 more
doaj   +1 more source

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor [PDF]

, 2015
The blood-brain barrier (BBB) is a critical structure that serves as the gatekeeper between the central nervous system and the rest of the body. It is the responsibility of the BBB to facilitate the entry of required nutrients into the brain and to ...
Aaron B. Bowman, Bryson M. Brewer, Clayton M. Britt, Cucullo L., Deyu Li, Dmitry A. Markov, Donna J. Webb, Germann B., Jacquelyn A. Brown, James M. May, John P. Wikswo, Lisa J. McCawley, M. Diana Neely, Mingjian Shi, Molino Y., Orlando S. Hoilett, Philip C. Samson, Qing Yang, Ronald S. Reiserer, Vanessa Allwardt, Virginia Pensabene, Zar J. H.   +21 more
core   +1 more source

Cells in the 3D biomatrix on-chip: better mimicking the real micro-physiological system

Next Materials
Recent advances in microfluidic technology and biomaterial science have augmented the use of organ-on-chip (OoC) technology to closely mimic the human pathophysiology.
Michele D’Orazio, Joanna Filippi, Gianni Antonelli, Giorgia Curci, Paola Casti, Arianna Mencattini, Gianluca Cidonio, Eugenio Martinelli   +7 more
doaj   +1 more source

Organ-on-Chip Approaches for Intestinal 3D In Vitro Modeling

Cellular and Molecular Gastroenterology and Hepatology, 2021
The intestinal epithelium has one of the highest turnover rates in the human body, which is supported by intestinal stem cells. Culture models of intestinal physiology have been evolving to incorporate different tissue and microenvironmental elements ...
J. Pimenta, Ricardo Ribeiro, Raquel Almeida, P. Costa, M. A. da Silva, B. Pereira   +5 more
semanticscholar   +1 more source

Organs-on-chips: latest developments

Microphysiological Systems, 2019
Welcome to the collection of the current must-read open-access papers in the field of organs-on-chips that have become available in the second half of 2018. This quarterly editorial column will be compiled by Dr. Andries D. van der Meer, University of Twente, The Netherlands.
openaire   +1 more source

Enhanced transport of plant-produced rabies single chain antibody-RVG peptide fusion protein across an in cellulo blood-brain barrier device [PDF]

, 2017
The biomedical applications of antibody engineering are developing rapidly and have been expanded to plant expression platforms. In this study, we have generated a novel antibody molecule in planta for targeted delivery across the blood–brain barrier ...
Al-Shehri, Alyautdin, Alyautdin, Bird, Boado, Both, Bracci, Burrage, Chopy, Donnelly-Roberts, Eigenmann, Fooks, Friden, Fu, Greene, Gulyaev, Hefferon, Helm, Hemachudha, Hwang do, Jekic, Kim, Kohli, Kumar, Kwon, Lentz, Lentz, Lentz, Lentz, Lentz, Lentz, Lewis, Lim, Liu, Louie, Ma, Markoutsa, McQuarrie, Megret, Muller, Pardridge, Pardridge, Pardridge, Peyret, Rosales-Mendoza, Roy, Rustici, Sainsbury, Schwarze, Shahid, Shantavasinkul, Siflinger-Birnboim, Thoulouze, Tzartos, Uwanyiligira, Xiang, Yamauchi   +56 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Low-Voltage Continuous Electrospinning Patterning [PDF]

, 2016
Electrospinning is a versatile technique for the construction of microfibrous and nanofibrous structures with considerable potential in applications ranging from textile manufacturing to tissue engineering scaffolds. In the simplest form, electrospinning
Gill, EL, Huang, YYS, Li, X, Li, Z, Liu, Y, Ma, G, Meng, F, Pritchard, RH, Wang, L   +8 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source