Results 101 to 110 of about 69,325 (340)
Incorporation of resident macrophages in engineered tissues: multiple cell type response to microenvironment controlled macrophage-laden gelatin hydrogels [PDF]
, 2017 The success of tissue engineering strategy is strongly related to the inflammatory response, mainly through the activity of macrophages that are key cells in initial immune response to implants.
Barthes, Julien +7 more
core +5 more sources
An Organ‐on‐Chip Platform for Simulating Drug Metabolism Along the Gut–Liver Axis
Advanced Healthcare MaterialsThe human microbiome significantly influences drug metabolism through the gut–liver axis, leading to modified drug responses and potential toxicity. Due to the complex nature of the human gut environment, the understanding of microbiome‐driven impacts on
Mara Lucchetti +7 more
semanticscholar +1 more source
Applications of Polymers for Organ-on-Chip Technology in Urology
Polymers, 2022 Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ biomimetic systems. OOC technology brings numerous advantages in the current landscape of preclinical models, capable of recapitulating the multicellular assemblage ...
B. Gălățeanu +8 more
semanticscholar +1 more source
Nature Reviews Drug Discovery, 2021 Organs-on-chips (OoCs), also known as microphysiological systems or ‘tissue chips’ (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process.
Low, Lucie A. +4 more
openaire +1 more source
The Role of Microfluidics for Organ on Chip Simulations [PDF]
Bioengineering, 2017 A multichannel three-dimensional chip of a microfluidic cell culture which enables the simulation of organs is called an “organ on a chip” (OC). With the integration of many other technologies, OCs have been mimicking organs, substituting animal models, and diminishing the time and cost of experiments which is better than the preceding conventional in ...
Aziz, Aziz Ur Rehman +5 more
openaire +2 more sources
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity
Bioactive Materials, 2021 Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental exposure.
Rick Xing Ze Lu, Milica Radisic
doaj +1 more source
Emerging tumor spheroids technologies for 3D in vitro cancer modeling [PDF]
, 2018 "Article in Press, Available online 31 October 2017" ; "S0163-7258(17)30268-1"Cancer is a leading cause of mortality and morbidity worldwide. Around 90% of deaths are caused by metastasis and just 10% by primary tumor.
Alemany-Ribes +133 more
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source