Results 91 to 100 of about 69,325 (340)

Fabrication of continuous iron wire reinforced poly-L-lactic acid (PLLA) filaments for producing biodegradable stents via a braiding process

Results in Engineering
Poly-L-lactic acid (PLLA) is widely used in medical applications due to its excellent biodegradability and biocompatibility. However, its limited mechanical strength poses challenges for applications like biodegradable stents, which require both strength
Yuanyuan Chen, Handai Liu, Emma J. Murphy, Gustavo Waltzer Fehrenbach, Tielidy Angelina De Morais De Lima, Dhanyamol George, Niall Burke, Aiden Flannagan   +7 more
doaj   +1 more source

MINERVA: The technological project to boost research on the microbiota-gut-brain axis in chronic neurodegenerative disorders [PDF]

, 2017
Chronic neurodegenerative disorders including dementias, as Alzheimer's disease (AD) and movement disorders, as Parkinson's disease (PD) are strongly increasing worldwide. Up to now, very little is known about their biochemical mechanism and no effective
Albani, Diego, Giordano, Carmen
core  

Allometric Scaling and Cell Ratios in Multi-Organ in vitro Models of Human Metabolism [PDF]

, 2014
Intelligent in vitro models able to recapitulate the physiological interactions between tissues in the body have enormous potential as they enable detailed studies on specific two-way or higher order tissue communication.
Arti Ahluwalia, Nadia Ucciferri, Tommaso Sbrana   +2 more
core   +2 more sources

Microsensor systems for cell metabolism - from 2D culture to organ-on-chip (2019-2024).

Lab on a Chip
Cell cultures, organs-on-chip and microphysiological systems become increasingly relevant as in vitro models, e.g., in drug development, disease modelling, toxicology or cancer research.
Johannes Dornhof, J. Kieninger, S. J. Rupitsch, A. Weltin   +3 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Antibacterial Potential of Essential Oils Against E. coli and Salmonella spp. in Minimally Processed Foods

Bacteria
Minimally processed foods (MPFs), often considered ready-to-eat, do not undergo cooking and therefore require proper handling and preparation to ensure safety. If not handled correctly, these foods can serve as a pathway for diseases caused by pathogenic
Aline Sitowski, Gladis Aver Ribeiro, Emma J. Murphy, Gustavo Waltzer Fehrenbach   +3 more
doaj   +1 more source

Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery

Frontiers in Bioengineering and Biotechnology, 2022
Human Microphysiological Systems (hMPS), otherwise known as organ- and tissue-on-a-chip models, are an emerging technology with the potential to replace in vivo animal studies with in vitro models that emulate human physiology at basic levels.
Raquel E. Ajalik, Raquel E. Ajalik, Rahul G. Alenchery, Rahul G. Alenchery, John S. Cognetti, Victor Z. Zhang, Victor Z. Zhang, James L. McGrath, Benjamin L. Miller, Benjamin L. Miller, Hani A. Awad, Hani A. Awad   +11 more
doaj   +1 more source

Pump‐Less, Recirculating Organ‐on‐Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver

Advanced Healthcare Materials
Type 2 diabetes mellitus (T2DM), obesity, and metabolic dysfunction‐associated steatotic liver disease (MASLD) are epidemiologically correlated disorders with a worldwide growing prevalence.
Aleksandra Aizenshtadt, Chencheng Wang, Shadab Abadpour, Pedro Duarte Menezes, Ingrid Wilhelmsen, Andrea Dalmao-Fernandez, Justyna Stokowiec, Alexey Golovin, M. Johnsen, T. Combriat, H. Røberg-Larsen, Nikolaj Gadegaard, Hanne Scholz, Mathias Busek, Stephan J K Krauss   +14 more
semanticscholar   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Development of Organ-on-Chip for the Study of Placental Pathologies: A Ten-Year Study of Literature Published

Health Technology Assessment in Action, 2023
Context: The placenta performs a crucial function in nutrient exchange, but studying this tissue poses a number of challenges. Utilizing microfluidic and microfabrication technologies, a 3D placenta-on-a-chip model provides a biomimetic alternative for ...
Ravindra Kalode, Pranoti Kalode
doaj   +1 more source