Results 111 to 120 of about 69,325 (340)

Mimicking and surpassing the xenograft model with cancer-on-chip technology

EBioMedicine, 2021
Organs-on-chips are in vitro models in which human tissues are cultured in microfluidic compartments with a controlled, dynamic micro-environment. Specific organs-on-chips are being developed to mimic human tumors, but the validation of such ‘cancer-on ...
Job Komen, Sanne M. van Neerven, Albert van den Berg, Louis Vermeulen, Andries D. van der Meer   +4 more
doaj   +1 more source

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies [PDF]

, 2019
The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system.
A Doran, A Herland, A Mahringer, A Regina, A Triantafyllou, A Wolff, AV Zhdanov, B Feng, B Oller-Salvia, B Rochat, B Srinivasan, BB Weksler, BD Gastfriend, BM Maoz, C Greene, EA Neuwelt, EG Geier, EK Hollmann, ES Lippmann, ES Lippmann, FC Thomas, FE O’Brien, GD Vatine, GL Semenza, H Abdollahi, H Burger, H Sade, HC Helms, JA Brown, JC Kalvass, JF Chen, JM Stenman, K Lauschke, KH Benam, KM Baeten, KS Kim, L Cucullo, L Tang, Louise Delsing, M Campisi, M Demeule, M Jorfi, M Li, M Ribecco-Lutkiewicz, ME Katt, ME Katt, MJ Stebbins, NJ Abbott, NR Wevers, OYF Henry, Q Wang, Q Zhang, R Cecchelli, R Daneman, R Shawahna, RM Linville, S Chakraborty, S Cisternino, S Kusuma, S Roman-Goldstein, S Sances, SN Bhatia, SW Lee, T Ohnishi, TR Doeppner, V Kiviniemi, W Löscher, W-L Yeh, WM Pardridge, WP Mason, Y Han, YI Wang, YJ Yu   +72 more
core   +1 more source

Early prediction of neoadjuvant chemotherapy response by exploiting a transfer learning approach on breast DCE-MRIs

Scientific Reports, 2021
The dynamic contrast-enhanced MR imaging plays a crucial role in evaluating the effectiveness of neoadjuvant chemotherapy (NAC) even since its early stage through the prediction of the final pathological complete response (pCR).
Maria Colomba Comes, Annarita Fanizzi, Samantha Bove, Vittorio Didonna, Sergio Diotaiuti, Daniele La Forgia, Agnese Latorre, Eugenio Martinelli, Arianna Mencattini, Annalisa Nardone, Angelo Virgilio Paradiso, Cosmo Maurizio Ressa, Pasquale Tamborra, Vito Lorusso, Raffaella Massafra   +14 more
doaj   +1 more source

Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing [PDF]

, 2018
Precise fluid height sensing in open-channel microfluidics has long been a desirable feature for a wide range of applications. However, performing accurate measurements of the fluid level in small-scale reservoirs (
Griffith, Linda G, Kassis, Timothy, Noh, Minkyun, Soenksen Martinez, Luis Ruben, Trumper, David L   +4 more
core   +1 more source

Refining Host-Pathogen Interactions: Organ-on-Chip Side of the Coin

Pathogens, 2021
Bioinspired organ-level in vitro platforms that recapitulate human organ physiology and organ-specific responses have emerged as effective technologies for infectious disease research, drug discovery, and personalized medicine.
Buket Baddal, P. Marrazzo
semanticscholar   +1 more source

Artificial Intelligence‐based Online Symptom Assessment Tools for Systemic Lupus Erythematosus (SLE) diagnosis: Patient Perspectives

Arthritis Care &Research, Accepted Article.
Objective The objective of this article is to identify perceptions of SLE patients regarding artificial intelligence (AI)‐based online symptom assessment tools, and the potential of these tools to address diagnostic barriers. Methods Adults from our SLE research cohort were invited to participate in 60‐90 minute virtual focus groups concerning their ...
Olivia A. Stein, Jennifer LF. Lee, Evelyne Vinet, Arielle Mendel, Christian A. Pineau, Fares Kalache, Louis‐Pierre Grenier, Sasha Bernatsky   +7 more
wiley   +1 more source

Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects

Biomedicines
Background/Objectives: Liver-on-a-chip (LiOC) technology is increasingly recognized as a transformative platform for modeling liver biology, disease mechanisms, drug metabolism, and toxicity screening.
Joseph Mugaanyi, Jing Huang, Jiongze Fang, Arthur Musinguzi, Caide Lu, Zaozao Chen   +5 more
doaj   +1 more source

Bioprinting of Organ-on-Chip Systems: A Literature Review from a Manufacturing Perspective

Journal of Manufacturing and Materials Processing, 2021
This review discusses the reported studies investigating the use of bioprinting to develop functional organ-on-chip systems from a manufacturing perspective.
Ketan Thakare, Laura Jerpseth, Zhijian Pei, Alaa Elwany, Francis Quek, Hongmin Qin   +5 more
doaj   +1 more source

Cardiac Meets Skeletal: What's New in Microfluidic Models for Muscle Tissue Engineering [PDF]

, 2016
In the last few years microfluidics and microfabrication technique principles have been extensively exploited for biomedical applications. In this framework, organs-on-a-chip represent promising tools to reproduce key features of functional tissue units ...
Bersini, Simone, Gilardi, Mara, Marsano, Anna, Moretti, Matteo, Rasponi, Marco, Visone, Roberta   +5 more
core   +2 more sources

Investigation of steatosis profiles induced by pesticides using liver organ-on-chip model and omics analysis.

Food and Chemical Toxicology, 2021
Several studies have reported a correlation between pesticides exposure and metabolic disorders. Dichlorodiphenyltrichloroethane (DDT) and permethrin (PMT), two pesticides highly prevalent in the environment, have been associated to dysregulation of ...
R. Jellali, S. Jacques, Amal Essaouiba, Françoise Gilard, F. Letourneur, B. Gakière, C. Legallais, E. Leclerc   +7 more
semanticscholar   +1 more source