FindFoci: a focus detection algorithm with automated parameter training that closely matches human assignments, reduces human inconsistencies and increases speed of analysis [PDF]
, 2014 Accurate and reproducible quantification of the accumulation of proteins into foci in cells is essential for data interpretation and for biological inferences.
A Bergman +47 more
core +9 more sources
Targeting the tumor microenvironment in colorectal peritoneal metastases
, 2020 Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim +4 more
core +1 more source
Bone Marrow–on–a–Chip Replicates Hematopoietic Niche Physiology in Vitro [PDF]
, 2014 Current in vitro hematopoiesis models fail to demonstrate the cellular diversity and complex functions of living bone marrow; hence, most translational studies relevant to the hematologic system are conducted in live animals.
Collins, James J. +7 more
core +1 more source
Creating a kidney organoid-vasculature interaction model using a novel organ-on-chip system
Scientific Reports, 2022 Kidney organoids derived from human induced pluripotent stem cells (iPSCs) have proven to be a valuable tool to study kidney development and disease. However, the lack of vascularization of these organoids often leads to insufficient oxygen and nutrient ...
A. Bas-Cristóbal Menéndez +11 more
semanticscholar +1 more source
Current Opinion in Toxicology, 2019 Blood hypercoagulability and thrombosis have been observed in patients during clinical trials of candidate drugs, yet these safety risks are seldom identified during preclinical testing, leading to increased mortality and morbidity, and increased attrition rates in the clinic.
Yunki Lee, Song Ih Ahn, YongTae Kim
openaire +2 more sources
A promising platform for predicting toxicity. [PDF]
, 2021 Organ-on-chip approaches could help researchers to better predict the toxicity of cancer immunotherapy ...
Ochoa de Olza, M.
core +1 more source
Advancement of Sensor Integrated Organ-on-Chip Devices
Italian National Conference on Sensors, 2021 Organ-on-chip devices have provided the pharmaceutical and tissue engineering worlds much hope since they arrived and began to grow in sophistication. However, limitations for their applicability were soon realized as they lacked real-time monitoring and
Gabriel A. Clarke +10 more
semanticscholar +1 more source
Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices
Frontiers in Bioengineering and Biotechnology, 2023 Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is
Cristian F. Rodríguez +6 more
doaj +1 more source
Basement membrane properties and their recapitulation in organ-on-chip applications
Materials Today Bio, 2022 Drug discovery and toxicology is a complex process that involves considerable basic research and preclinical evaluation. These depend highly on animal testing which often fails to predict human trial outcomes due to species differences.
G. Salimbeigi +4 more
semanticscholar +1 more source
DESIGN AND DEVELOPMENT OF A MICROFLUIDIC DEVICE FOR THE ASSESSMENT OF FIRST-PASS METABOLISM [PDF]
, 2017 The aim of the thesis is to develop a microfluidic platform in order to mimic the first pass metabolism of oral ingested compounds. In the first part of the thesis, there is an introduction about the in vivo mechanism involved in the in process of first ...
Corrado, Brunella
core +1 more source