Results 61 to 70 of about 67,848,505 (299)

Scalability of Network-on-Chip communication architecture for 3-D meshes. [PDF]

, 2009
Design constraints imposed by global interconnect delays as well as limitations in integration of disparate technologies make 3D chip stacks an enticing technology solution for massively integrated electronic systems.
Awet Yemane Weldezion, Tenhunen, Hannu, Matt Grange, Roshan Weerasekera, Grange, M, Jantsch, A, Weldezion, Awet Yemane,, Pamunuwa, Dinesh Bandara, Jantsch, A., Zhonghai Lu, Lu, Zhonghai, Pamunuwa, Dinesh, Dinesh Pamunuwa, Pamunuwa, I D B, Axel Jantsch, Weldezion, A., Weldezion, A. Y., Jantsch, Axel,, Tenhunen, Hannu,, Weerasekera, Roshan, Hannu Tenhunen, Tenhunen, H, Grange, M., Lu, Zhonghai,, Weerasekera, R., Grange, Matt   +25 more
core   +1 more source

Organs-on-chips

Nature Reviews Drug Discovery, 2021
Organs-on-chips (OoCs), also known as microphysiological systems or ‘tissue chips’ (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process.
Low, Lucie A., Mummery, Christine, Berridge, Brian R., Austin, Christopher P., Tagle, Danilo A.   +4 more
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery

Frontiers in Bioengineering and Biotechnology, 2022
Human Microphysiological Systems (hMPS), otherwise known as organ- and tissue-on-a-chip models, are an emerging technology with the potential to replace in vivo animal studies with in vitro models that emulate human physiology at basic levels.
Raquel E. Ajalik, Raquel E. Ajalik, Rahul G. Alenchery, Rahul G. Alenchery, John S. Cognetti, Victor Z. Zhang, Victor Z. Zhang, James L. McGrath, Benjamin L. Miller, Benjamin L. Miller, Hani A. Awad, Hani A. Awad   +11 more
doaj   +1 more source

Towards the joint on a chip: double layered directly interfaced tissues to mimic the Osteoarthritic cartilage-subchondral interface

, 2020
Osteoarthritis (OA) is the most diffused musculoskeletal disease and a worldwide cause of pain and disability. Although OA’s most evidently affected tissue is cartilage (AC), pathological changes regard the whole joint.
Andrea Mainardi, Paola Occhetta, Andrea Barbero, Ivan Martin, Stefano Ugolini, Marco Rasponi   +5 more
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Antibacterial Potential of Essential Oils Against E. coli and Salmonella spp. in Minimally Processed Foods

Bacteria
Minimally processed foods (MPFs), often considered ready-to-eat, do not undergo cooking and therefore require proper handling and preparation to ensure safety. If not handled correctly, these foods can serve as a pathway for diseases caused by pathogenic
Aline Sitowski, Gladis Aver Ribeiro, Emma J. Murphy, Gustavo Waltzer Fehrenbach   +3 more
doaj   +1 more source

Engineering human islet organoids from iPSCs using an organ-on-chip platform

, 2019
Human pluripotent stem cell (hPSC)-derived islet cells provide promising resources for diabetes studies, cell replacement treatment and drug screening.
Li, Zhongyu, Qin, Jianhua, Su, Wentao, Wang, Yaqing, Guo, Yaqiong, Deng, Pengwei, Tao, Tingting, Chen, Wenwen   +7 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source