Results 41 to 50 of about 67,848,505 (299)

Physiologically relevant organs on chips [PDF]

Biotechnology Journal, 2013
AbstractRecent advances in integrating microengineering and tissue engineering have generated promising microengineered physiological models for experimental medicine and pharmaceutical research. Here we review the recent development of microengineered physiological systems, or also known as “ogans‐on‐chips”, that reconstitute the physiologically ...
Kyungsuk, Yum, Soon Gweon, Hong, Kevin E, Healy, Luke P, Lee   +3 more
openaire   +2 more sources

Microfluidic Platforms to Unravel Mysteries of Alzheimer’s Disease: How Far Have We Come?

Life, 2021
Alzheimer’s disease (AD) is a significant health concern with enormous social and economic impact globally. The gradual deterioration of cognitive functions and irreversible neuronal losses are primary features of the disease.
Pragya Prasanna, Shweta Rathee, Vedanabhatla Rahul, Debabrata Mandal, Macherla Sharath Chandra Goud, Pardeep Yadav, Susan Hawthorne, Ankur Sharma, Piyush Kumar Gupta, Shreesh Ojha, Niraj Kumar Jha, Chiara Villa, Saurabh Kumar Jha   +12 more
doaj   +1 more source

High-resolution and multi-range particle separation by microscopic vibration in an optofluidic chip

, 2017
An optofluidic chip is demonstrated in experiments for high-resolution and multi-range particle separation through the optically-induced microscopic vibration effect, where nanoparticles are trapped in loosely overdamped optical potential wells created ...
Zhang, Jing Bo, Liedberg, B., Liedberg, Bo, P. H. Yap, Y. Zhang, Yap, P. H., Zhang, Yi, Xiong, S., Zhang, Y., Chen, T. N., Y. L. Hao, Chin, Lip Ket, Chin, L. K., S. Xiong, Shi, Yu Zhi, Ser, Wee, Y. Yang, W. Ser, Liu, A. Q., J. B. Zhang, Xiong, Sha, Hao, Yi Long, J. H. Wu, Hao, Y. L., Chen, Tian Ning, A. Q. Liu, Y. Z. Shi, Wu, Jiu Hui, Zhang, J. B., B. Liedberg, Yang, Z. C., Yang, Y., Wu, J. H., Ser, W., Yang, Zhen Chuan, Yap, Peng Huat, Shi, Y. Z., Liu, Ai Qun, T. N. Chen, Z. C. Yang, L. K. Chin, Yang, Yi   +41 more
core   +1 more source

Guiding organs-on-chips towards applications: a balancing act between integration of advanced technologies and standardization

Frontiers in Lab on a Chip Technologies
Organs-on-chips (OoC) are in vitro models that emulate key functionalities of tissues or organs in a miniaturized and highly controlled manner. Due to their high versatility, OoC have evolved as promising alternatives to animal testing for a more ...
J. Meneses, F. Conceição, A. D. van der Meer, A. D. van der Meer, S. de Wit, L. Moreira Teixeira, L. Moreira Teixeira   +6 more
doaj   +1 more source

3D Inkjet-Bioprinted Lung-on-a-Chip

, 2023
There is an urgent need for physiologically relevant and customizable biochip models of human lung tissue to provide a niche for lung disease modeling and drug efficacy.
Dayoon Kang, Taejeong Kwak (15334091), Hwa-Rim Lee, Wookyeom Kim (15334082), Sungjune Jung (3236640), Wookyeom Kim, Yunji Lee, Hwa-Rim Lee (9072215), Taejeong Kwak, Sungjune Jung, Yunji Lee (15334085), Dayoon Kang (15334088)   +11 more
core   +1 more source

Cells in the 3D biomatrix on-chip: better mimicking the real micro-physiological system

Next Materials
Recent advances in microfluidic technology and biomaterial science have augmented the use of organ-on-chip (OoC) technology to closely mimic the human pathophysiology.
Michele D’Orazio, Joanna Filippi, Gianni Antonelli, Giorgia Curci, Paola Casti, Arianna Mencattini, Gianluca Cidonio, Eugenio Martinelli   +7 more
doaj   +1 more source

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

, 2022
S.2688-2699Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied
Drewell, Christopher, Sambo, Naomia Sisoli, Thomas, Alexander, Lauster, Roland, Lorenz, Alexandra K., Lindner, Marcus, Maschmeyer, Ilka, Ramme, Anja P., Bauer, Sophie, Marx, Uwe, Schimek, Katharina, Hübner, Juliane, Hasenberg, Tobias, Sonntag, Frank   +13 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cold Atmospheric Plasma as a Potential Disease-Modifying Therapy for Osteoarthritis

Biomedicines
Osteoarthritis (OA) is a disabling joint disease characterised by cartilage degradation, synovial inflammation, and subchondral bone remodelling. Furthermore, catabolic inflammatory processes as well as dysregulated cellular signalling and oxidative ...
Vinay Kumar, Fiona O’Neill, Emma J. Murphy, Declan M. Devine, Liam O’Neill, Niamh Fahy   +5 more
doaj   +1 more source

Microelectromechanical Organs-on-Chip

2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), 2021
Stemming from the convergence of tissue engineering and microfluidics, organ-on-chip (OoC) technology can reproduce in vivo-like dynamic microphysiological environments for tissues in vitro. The possibility afforded by OoC devices of realistic recapitulation of tissue and organ (patho)physiology may hold the key to bridge the current translational gap ...
Mastrangeli, Massimo (author), Aydogmus, H. (author), Dostanic, M. (author), Motreuil-Ragot, P.A. (author), Revyn, N. (author), de Wagenaar, B. (author), Dekker, R. (author), Sarro, Pasqualina M (author)   +7 more
openaire   +3 more sources