Results 41 to 50 of about 59,126 (260)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Fabrication of continuous iron wire reinforced poly-L-lactic acid (PLLA) filaments for producing biodegradable stents via a braiding process

Results in Engineering
Poly-L-lactic acid (PLLA) is widely used in medical applications due to its excellent biodegradability and biocompatibility. However, its limited mechanical strength poses challenges for applications like biodegradable stents, which require both strength
Yuanyuan Chen, Handai Liu, Emma J. Murphy, Gustavo Waltzer Fehrenbach, Tielidy Angelina De Morais De Lima, Dhanyamol George, Niall Burke, Aiden Flannagan   +7 more
doaj   +1 more source

Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery

Frontiers in Bioengineering and Biotechnology, 2022
Human Microphysiological Systems (hMPS), otherwise known as organ- and tissue-on-a-chip models, are an emerging technology with the potential to replace in vivo animal studies with in vitro models that emulate human physiology at basic levels.
Raquel E. Ajalik, Raquel E. Ajalik, Rahul G. Alenchery, Rahul G. Alenchery, John S. Cognetti, Victor Z. Zhang, Victor Z. Zhang, James L. McGrath, Benjamin L. Miller, Benjamin L. Miller, Hani A. Awad, Hani A. Awad   +11 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Antibacterial Potential of Essential Oils Against E. coli and Salmonella spp. in Minimally Processed Foods

Bacteria
Minimally processed foods (MPFs), often considered ready-to-eat, do not undergo cooking and therefore require proper handling and preparation to ensure safety. If not handled correctly, these foods can serve as a pathway for diseases caused by pathogenic
Aline Sitowski, Gladis Aver Ribeiro, Emma J. Murphy, Gustavo Waltzer Fehrenbach   +3 more
doaj   +1 more source

Development of Organ-on-Chip for the Study of Placental Pathologies: A Ten-Year Study of Literature Published

Health Technology Assessment in Action, 2023
Context: The placenta performs a crucial function in nutrient exchange, but studying this tissue poses a number of challenges. Utilizing microfluidic and microfabrication technologies, a 3D placenta-on-a-chip model provides a biomimetic alternative for ...
Ravindra Kalode, Pranoti Kalode
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Role of Microfluidics for Organ on Chip Simulations [PDF]

Bioengineering, 2017
A multichannel three-dimensional chip of a microfluidic cell culture which enables the simulation of organs is called an “organ on a chip” (OC). With the integration of many other technologies, OCs have been mimicking organs, substituting animal models, and diminishing the time and cost of experiments which is better than the preceding conventional in ...
Aziz, Aziz Ur Rehman, Geng, Chunyang, Fu, Mengjie, Yu, Xiaohui, Qin, Kairong, Liu, Bo   +5 more
openaire   +2 more sources