Results 41 to 50 of about 69,325 (340)

Organ-on-Chip In Development:Towards a roadmap for Organs-on-Chip

ALTEX, 2019
Organ-on-Chip is a game-changing technology born from the convergence of tissue engineering and microfluidic technology. Organ-on-Chip devices (OoCs) are expected to offer effective solutions to persisting problems in drug development and personalized disease treatments.
M. Mastrangeli, S. Millet, the ORCHID partners, J. van den Eijnden-van Raaij   +3 more
openaire   +6 more sources

Modular Microphysiological System for Modeling of Biologic Barrier Function

Frontiers in Bioengineering and Biotechnology, 2020
Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,
Matthew Ishahak, Jordan Hill, Quratulain Amin, Laura Wubker, Adiel Hernandez, Alla Mitrofanova, Alexis Sloan, Alessia Fornoni, Alessia Fornoni, Ashutosh Agarwal, Ashutosh Agarwal   +10 more
doaj   +1 more source

An organ-on-chip device with integrated charge sensors and recording microelectrodes

Scientific Reports, 2023
Continuous monitoring of tissue microphysiology is a key enabling feature of the organ-on-chip (OoC) approach for in vitro drug screening and disease modeling.
H. Aydogmus, Michel Hu, Lovro Ivancevic, Jean-Philippe Frimat, A. M. van den Maagdenberg, P. Sarro, M. Mastrangeli   +6 more
semanticscholar   +1 more source

Organs on chip approach: A tool to evaluate cancer-immune cells interactions [PDF]

, 2017
In this paper we discuss the applicability of numerical descriptors and statistical physics concepts to characterize complex biological systems observed at microscopic level through organ on chip approach. To this end, we employ data collected on a micro
Agliari, Elena, Barra, Adriano, Bertani, FRANCESCA ROMANA, Biselli, Elena, Businaro, Luca, De Ninno, Adele, Di Giuseppe, Davide, Di Natale, Corrado, Gerardino, Annamaria, Kroemer, Guido, Lucarini, Valeria, Martinelli, Eugenio, Mattei, Fabrizio, Mencattini, Arianna, Schiavoni, Giovanna, Vacchelli, Erika   +15 more
core   +3 more sources

Organs-on-chips: a decade of innovation

Trends in Biotechnology, 2023
Recreating 'living organs' with groundbreaking organ-on-a-chip (OOC) technologies is facilitating a new era of drug discovery. Studies by Huh et al. and Ronaldson-Bouchard et al. underscore advances made over a decade, spanning single organ functionality to interconnected organs, that enable examination of drug toxicities and disease pathogenesis in ...
Carly Strelez, Hannah Y. Jiang, Shannon M. Mumenthaler   +2 more
openaire   +2 more sources

Glioma-on-a-Chip Models

Micromachines, 2021
Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun, Sajjad Rahmani Dabbagh, Irem Sultan Ilci, Tugba Bagci-Onder, Savas Tasoglu   +4 more
doaj   +1 more source

The translational roadmap of the gut models, focusing on gut-on-chip [version 2; peer review: 2 approved]

Open Research Europe, 2023
It is difficult to model in vitro the intestine when seeking to include crosstalk with the gut microbiota, immune and neuroendocrine systems. Here we present a roadmap of the current models to facilitate the choice in preclinical and translational ...
Giulia Malaguarnera, Antoni Homs Corbera, Miriam Graute   +2 more
doaj   +1 more source

Multi-scale cellular engineering: From molecules to organ-on-a-chip. [PDF]

, 2020
Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems.
Cahan, Patrick, Chaudhuri, Ovijit, Engler, Adam J, Huang, Ngan F, Khademhosseini, Ali, Kumar, Sanjay, Li, Song, Wang, Aijun, Wang, Yingxiao   +8 more
core   +2 more sources

Microfluidics for Advanced Drug Delivery Systems. [PDF]

, 2015
Considerable efforts have been devoted towards developing effective drug delivery methods. Microfluidic systems, with their capability for precise handling and transport of small liquid quantities, have emerged as a promising platform for designing ...
Dokmeci, Mehmet R, Ghaemmaghami, Amir, Khademshosseini, Ali, Riahi, Reza, Shaegh, Seyed Ali Mousavi, Tamayol, Ali   +5 more
core   +1 more source

A multi-organ-on-chip to recapitulate the infiltration and the cytotoxic activity of circulating NK cells in 3D matrix-based tumor model

Frontiers in Bioengineering and Biotechnology, 2022
The success of immunotherapeutic approaches strictly depends on the immune cells interaction with cancer cells. While conventional in vitro cell cultures under-represent the complexity and dynamic crosstalk of the tumor microenvironment, animal models do
M. Marzagalli, Giorgia Pelizzoni, Arianna Fedi, Chiara Vitale, F. Fontana, S. Bruno, A. Poggi, A. Dondero, Maurizio Aiello, R. Castriconi, C. Bottino, S. Scaglione   +11 more
semanticscholar   +1 more source