Results 1 to 10 of about 62,689 (299)
Organ-on-a-chip and the kidney
Kidney Research and Clinical Practice, 2015 Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated.
Sejoong Kim, Shuichi Takayama
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Oncoimmunology Meets Organs-on-Chip [PDF]
Frontiers in Molecular Biosciences, 2021 Oncoimmunology represents a biomedical research discipline coined to study the roles of immune system in cancer progression with the aim of discovering novel strategies to arm it against the malignancy.
Fabrizio Mattei +8 more
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Journey of organ on a chip technology and its role in future healthcare scenario
Applied Surface Science Advances, 2022 Organ on a chip refers to microengineered biomimetic system which reflects structural and functional characteristics of human tissue. It involves biomaterial technology, cell biology and engineering combined together in a miniaturized platform.
Deepanmol Singh +4 more
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A workflow integrating organ-on-chip culture and correlative 3D light and electron microscopy for microtissue analysis [PDF]
Scientific ReportsCorrelative microscopy approaches offer powerful means to study tissue development across spatial scales, but combining 3D light and electron imaging remains technically challenging.
Judith M. Schaart +13 more
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Organ-on-chip technologies: Novel tools with the potential to revolutionize osteoarthritis research and clinical development [PDF]
Osteoarthritis and Cartilage OpenObjective: To critically evaluate the evolution of in vitro models for osteoarthritis (OA) research, with a specific focus on organ-on-chip (OOC) technologies, and to discuss their potential to overcome the limitations of traditional 2D, 3D, and explant ...
Carlo Alberto Paggi
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Engineered Vasculature for Organ-on-a-Chip Systems
Engineering, 2022 Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi +8 more
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Aggregate, 2023 Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more realistically compared to many animal models and conventional two‐dimensional cell cultures.
Sajjad Rahmani Dabbagh +5 more
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Organs-on-chips: into the next decade [PDF]
Nature Reviews Drug Discovery, 2020 Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue chips' (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process.
Lucie A. Low +4 more
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Patterns, 2021 Summary: One of the most challenging frontiers in biological systems understanding is fluorescent label-free imaging. We present here the NeuriTES platform that revisits the standard paradigms of video analysis to detect unlabeled objects and adapt to ...
Arianna Mencattini +12 more
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A directional 3D neurite outgrowth model for studying motor axon biology and disease
Scientific Reports, 2021 We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel,
Xandor M. Spijkers +5 more
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