Results 41 to 50 of about 62,689 (299)

Kinematische Analyse eines Parallelmechanismus zur automatisierten Bildgebung von Organ-on-a-Chip Kulturen [PDF]

, 2023
Organ-on-a-Chip approach makes it possible to produce vascularized organoids for pre-clinical drug studies using incubators and rockers. Automation of organoids generation is desirable to reduce human resources and increase reproducibility.
Eugster, Manuela, Rauter, Georg, DuEPublico: Duisburg-Essen Publications Online, University Of Duisburg-Essen, Schicklin, Cédric   +3 more
core   +1 more source

Guiding organs-on-chips towards applications: a balancing act between integration of advanced technologies and standardization

Frontiers in Lab on a Chip Technologies
Organs-on-chips (OoC) are in vitro models that emulate key functionalities of tissues or organs in a miniaturized and highly controlled manner. Due to their high versatility, OoC have evolved as promising alternatives to animal testing for a more ...
J. Meneses, F. Conceição, A. D. van der Meer, A. D. van der Meer, S. de Wit, L. Moreira Teixeira, L. Moreira Teixeira   +6 more
doaj   +1 more source

Engineering Organ-on-a-Chip to Accelerate Translational Research [PDF]

, 2022
We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a form of microengineered cell culture platform that elaborates the in-vivo like organ or tissue microenvironments.
Lee, Somin, Noo Jeon, Jeon, Noo Li, Somin Lee, Ko, Jihoon, Jihoon Ko, Burcu Gumuscu, Gumuscu, Burcu, Dohyun Park, Gumuscu, Burcu; id_orcid, Park, Dohyun, Noo Li Jeon   +11 more
core   +1 more source

Cells in the 3D biomatrix on-chip: better mimicking the real micro-physiological system

Next Materials
Recent advances in microfluidic technology and biomaterial science have augmented the use of organ-on-chip (OoC) technology to closely mimic the human pathophysiology.
Michele D’Orazio, Joanna Filippi, Gianni Antonelli, Giorgia Curci, Paola Casti, Arianna Mencattini, Gianluca Cidonio, Eugenio Martinelli   +7 more
doaj   +1 more source

Organ on Chip Technology to Model Cancer Growth and Metastasis

Bioengineering, 2022
Organ on chip (OOC) has emerged as a major technological breakthrough and distinct model system revolutionizing biomedical research and drug discovery by recapitulating the crucial structural and functional complexity of human organs in vitro.
Giorgia Imparato, Francesco Urciuolo, Paolo Antonio Netti   +2 more
doaj   +1 more source

Global Meta‐Analysis of Organoid and Organ‐on‐Chip Research [PDF]

, 2023
Organoids and cells in organ-on-chip platforms replicate higher-level anatomical, physiological, or pathological states of tissues and organs. These technologies are widely regarded by academia, the pharmacological industry and regulators as key ...
Christine L. Mummery, Stefan Krauss, Jun‐ya Shoji, Davis, R.P., Krauss, S., Davis, Richard P., Mummery, Christine L., Mummery, C.L., Richard P. Davis, Shoji, J.Y., Shoji, Jun ya, Krauss, Stefan   +11 more
core   +1 more source

Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications

, 2019
Organ-on-chips are miniaturised devices aiming at replacing animal models for drug discovery, toxicology and studies of complex biological phenomena. The field of Organ-On-Chip has grown exponentially, and has led to the formation of companies providing ...
Arianna Mencatti, Alfredo E. Ongaro, Lina Ghibelli, Vanessa Mancini, Vicki Stone, Maïwenn Kersaudy-Kerhoas, MaÃwenn Kersaudy-Kerhoas, Virginia Pensabene, Allende Miguelez Crespo, Krystian L. Wlodarczyk, Duncan P. Hand, Nicola Howarth, Davide Di Giuseppe, Vincenzo La Carrubba, Ali Kermanizadeh, Eugenio Martinelli   +15 more
core   +1 more source

WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue

, 2022
S.1645-1654Organ-on-a-chip systems possess a promising future as drug screening assays and as testbeds for disease modeling in the context of both single-organ systems and multi-organ-chips.
Zushin, P.J.H., Healy, K.E., Stahl, A., Reese, W.M., Loskill, P., Lee-Montiel, F.T., Jeeawoody, S., Sezhian, T., Tharp, K.M.   +8 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Organs-on-chips: latest developments

Microphysiological Systems, 2019
Welcome to the collection of the current must-read open-access papers in the field of organs-on-chips that have become available in the second half of 2018. This quarterly editorial column will be compiled by Dr. Andries D. van der Meer, University of Twente, The Netherlands.
openaire   +1 more source