Results 51 to 60 of about 62,689 (299)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Engineering human islet organoids from iPSCs using an organ-on-chip platform

, 2019
Human pluripotent stem cell (hPSC)-derived islet cells provide promising resources for diabetes studies, cell replacement treatment and drug screening.
Li, Zhongyu, Qin, Jianhua, Su, Wentao, Wang, Yaqing, Guo, Yaqiong, Deng, Pengwei, Tao, Tingting, Chen, Wenwen   +7 more
core   +1 more source

Organ-on-a-chip: current gaps and future directions. [PDF]

, 2022
As an emerging hot topic of the last decade, Organ on Chip (OoC) is a new technology that is attracting interest from both basic and translational scientists.
Hughes, David, Amour, Augustin, Guenat, O, Amour, A, Rowan, Wendy, Harris, Kate, Hughes, D, Rowan, W, Beken, S, David, R, Dal Negro, G, Candarlioglu, Pelin L., Guenat, Olivier, David, Rhiannon, Candarlioglu, Pelin L, Candarlioglu, PL, Harris, K, Beken, Sonja, Morgan, Hywel, Screen, H, Balkwill, Frances, Dal Negro, Gianni, Screen, Hazel, Morgan, H, Balkwill, F   +24 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organs-on-Chips

Current Opinion in Toxicology, 2019
Blood hypercoagulability and thrombosis have been observed in patients during clinical trials of candidate drugs, yet these safety risks are seldom identified during preclinical testing, leading to increased mortality and morbidity, and increased attrition rates in the clinic.
Yunki Lee, Song Ih Ahn, YongTae Kim
openaire   +2 more sources

Fabrication of continuous iron wire reinforced poly-L-lactic acid (PLLA) filaments for producing biodegradable stents via a braiding process

Results in Engineering
Poly-L-lactic acid (PLLA) is widely used in medical applications due to its excellent biodegradability and biocompatibility. However, its limited mechanical strength poses challenges for applications like biodegradable stents, which require both strength
Yuanyuan Chen, Handai Liu, Emma J. Murphy, Gustavo Waltzer Fehrenbach, Tielidy Angelina De Morais De Lima, Dhanyamol George, Niall Burke, Aiden Flannagan   +7 more
doaj   +1 more source

Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery

Frontiers in Bioengineering and Biotechnology, 2022
Human Microphysiological Systems (hMPS), otherwise known as organ- and tissue-on-a-chip models, are an emerging technology with the potential to replace in vivo animal studies with in vitro models that emulate human physiology at basic levels.
Raquel E. Ajalik, Raquel E. Ajalik, Rahul G. Alenchery, Rahul G. Alenchery, John S. Cognetti, Victor Z. Zhang, Victor Z. Zhang, James L. McGrath, Benjamin L. Miller, Benjamin L. Miller, Hani A. Awad, Hani A. Awad   +11 more
doaj   +1 more source

Organs-on-chips: a decade of innovation

Trends in Biotechnology, 2023
Recreating 'living organs' with groundbreaking organ-on-a-chip (OOC) technologies is facilitating a new era of drug discovery. Studies by Huh et al. and Ronaldson-Bouchard et al. underscore advances made over a decade, spanning single organ functionality to interconnected organs, that enable examination of drug toxicities and disease pathogenesis in ...
Carly Strelez, Hannah Y. Jiang, Shannon M. Mumenthaler   +2 more
openaire   +2 more sources

Multistep Fluidic Control Network toward the Automated Generation of Organ-on-a-Chip

, 2019
Organ-on-a-chip, which mimics physiological functions of organs, is a potential tool for drug development and precision medicine. This chip, accompanied by a suitable culture environment and appropriate culture procedure, allows cells to form functional ...
Jen-Huang Huang, Jen-Huang Huang (452919), Pulak Nath, Pulak Nath (2400136), Hsin-Lin Hsieh, Hsin-Lin Hsieh (7115480)   +5 more
core   +1 more source

The tooth on-a-chip: a microphysiologic model system mimicking the biologic interface of the tooth with biomaterials

, 2020
The tooth has a unique configuration with respect to biomaterials that are used for its treatment. Cells inside of the dental pulp interface indirectly with biomaterials via a calcified permeable membrane, formed by the dentin matrix and several ...
Bertassoni, Luiz E., Puppin Rontani, Regina Maria, Sereda, Grigoriy, Franca, Cristiane Miranda, Rodrigues, Nara Sousa, Tahayeri, Anthony, Ferdosian, Shirin, Ferracane, Jack L.   +7 more
core   +1 more source