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Cells, 2020 Much interest has been directed towards stem cells, both in basic and translational research, to understand basic stem cell biology and to develop new therapies for many disorders.
Joni H. Ylostalo
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3D Cell Culture—Can It Be As Popular as 2D Cell Culture?
Advanced NanoBiomed Research, 2021 A 3D cell culture has developed rapidly in recent years, as cells growing on a flat substrate in a static environment are far from achieving an in vivo status. Currently, researchers have also gradually realized that to achieve cell morphology, structure,
Miao Sun +7 more
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Is It Time to Start Transitioning From 2D to 3D Cell Culture?
Frontiers in Molecular Biosciences, 2020 Cell culture is an important and necessary process in drug discovery, cancer research, as well as stem cell study. Most cells are currently cultured using two-dimensional (2D) methods but new and improved methods that implement three-dimensional (3D ...
Caleb Jensen +5 more
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In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models
SLAS Discovery, 2023 Three-dimensional (3D) cell culture technology has been steadily studied since the 1990′s due to its superior biocompatibility compared to the conventional two-dimensional (2D) cell culture technology, and has recently developed into an organoid culture ...
Sang-Yun Lee +3 more
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Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications [PDF]
ExplorationThree‐dimensional (3D) multicellular models are considered ideal methods for bridging the gap between two‐dimensional (2D) cell culture and animal models, which are widely used in organogenesis, disease models, drug development, and regenerative medicine.
Xinglong Zhu +8 more
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Advanced 3D Cell Culture Technologies and Formats. [PDF]
Bioengineering (Basel)The Special Issue “Advanced 3D Cell Culture Technologies and Formats” presents a collection of original research and review articles that explore recent innovations in three-dimensional (3D) cell culture systems aimed at enhancing the physiological relevance and therapeutic utility of cells and cell-derived products and assays [...]
Kasper C, Egger D.
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Design approaches for 3D cell culture and 3D bioprinting platforms. [PDF]
Biophys Rev (Melville)The natural habitat of most cells consists of complex and disordered 3D microenvironments with spatiotemporally dynamic material properties. However, prevalent methods of in vitro culture study cells under poorly biomimetic 2D confinement or homogeneous conditions that often neglect critical topographical cues and mechanical stimuli. It has also become
Sreepadmanabh M +2 more
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Establishment of patient-derived three-dimensional organoid culture in renal cell carcinoma [PDF]
Investigative and Clinical Urology, 2020 Purpose: Renal cell carcinoma is a heterogeneous kidney cancer, and over 403,000 cases were reported worldwide in 2018. Current methods for studying renal cell carcinoma are limited to two-dimensional (2D) culture of primary cell lines and patient ...
Joon Chae Na +9 more
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European Journal of Cell Biology, 2022 Mesenchymal stem cells (MSCs) show a decline in pluripotency and differentiation with increased cell culture passages in 2D cultures. The 2D monolayer culture fails to correctly imitate the architecture and microenvironments of in-vivo cell models ...
Gitika Thakur +10 more
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Deterministic culturing of single cells in 3D [PDF]
Scientific Reports, 2020 AbstractModels using 3D cell culture techniques are increasingly accepted as the most biofidelic in vitro representations of tissues for research. These models are generated using biomatrices and bulk populations of cells derived from tissues or cell lines. We present an alternate method to culture individually selected cells in relative isolation from
Rohil Jain +4 more
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