Results 21 to 30 of about 10,804,267 (253)

Muscle injury-induced hypoxia alters the proliferation and differentiation potentials of muscle resident stromal cells

Skeletal Muscle, 2019
Background Trauma-induced heterotopic ossification (HO) is a complication that develops under three conditions: the presence of an osteogenic progenitor cell, an inducing factor, and a permissive environment. We previously showed that a mouse multipotent
Geneviève Drouin, Vanessa Couture, Marc-Antoine Lauzon, Frédéric Balg, Nathalie Faucheux, Guillaume Grenier   +5 more
doaj   +1 more source

A miniaturized bioreactor system for the evaluation of cell interaction with designed substrates in perfusion culture [PDF]

, 2011
In tissue engineering, the chemical and topographical cues within three-dimensional (3D) scaffolds are normally tested using static cell cultures but applied directly to tissue cultures in perfusion bioreactors.
M. O. Riehle, J.R. Higginson (7130108), Higginson, J.R., Donoghue, P.S., T. Sun, Nikolaj Gadegaard (1292763), J. R. Higginson, N. Gadegaard, Riehle, M.O., Mathis O. Riehle (1292769), Barnett, S.C., Sun, T., Tao Sun (1255119), Peter S. Donoghue (7128581), S. C. Barnett, Gadegaard, N., P. S. Donoghue, Susan C. Barnett (7128590)   +17 more
core   +1 more source

Mesenchymal stem cells lose the senescent phenotype under 3D cultivation

Stem Cell Research & Therapy, 2023
Background Three-dimensional (3D) cell culture is widely used in various fields of cell biology. In comparison to conventional two-dimensional (2D) cell culture, 3D cell culture facilitates a more accurate replication of the in vivo microenvironment ...
O. Krasnova, A. Kovaleva, A. Saveleva, K. Kulakova, O. Bystrova, M. Martynova, A. Domnina, J. Sopova, I. Neganova   +8 more
doaj   +1 more source

3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumor microenvironment for drug response studies

Frontiers in Oncology, 2022
Traditional studies using cancer cell lines are often performed on a two-dimensional (2D) cell culture model with a low success rate of translating to Phase I or Phase II clinical studies. In comparison, with the advent of developments three-dimensional (
Huaikai Shi, Emma M. Rath, Ruby C. Y. Lin, Ruby C. Y. Lin, Ruby C. Y. Lin, Kadir Harun Sarun, Candice Julie Clarke, Brian C. McCaughan, Brian C. McCaughan, Helen Ke, Helen Ke, Anthony Linton, Anthony Linton, Anthony Linton, Kenneth Lee, Kenneth Lee, Sonja Klebe, Sonja Klebe, Joanneke Maitz, Joanneke Maitz, Joanneke Maitz, Kedong Song, Yiwei Wang, Yiwei Wang, Steven Kao, Steven Kao, Yuen Yee Cheng   +26 more
doaj   +1 more source

Adult Multipotent Cardiac Progenitor-Derived Spheroids: A Reproducible Model of In Vitro Cardiomyocyte Commitment and Specification

Cells, 2023
Background: Three-dimensional cell culture systems hold great promise for bridging the gap between in vitro cell-based model systems and small animal models to study tissue biology and disease.
Mariangela Scalise, Fabiola Marino, Luca Salerno, Nunzia Amato, Claudia Quercia, Chiara Siracusa, Andrea Filardo, Antonio Chiefalo, Loredana Pagano, Giuseppe Misdea, Nadia Salerno, Antonella De Angelis, Konrad Urbanek, Giuseppe Viglietto, Daniele Torella, Eleonora Cianflone   +15 more
doaj   +1 more source

Current Approaches to Three-Dimensional Cell Culture System

Namık Kemal Tıp Dergisi, 2020
Two-dimensional (2D) cell culture is a valuable method for cell-based research, However, it may provide unpredictable, misleading data on in vivo responses.
Elif POLAT
doaj   +1 more source

The Use of Biomaterials in Three-Dimensional Culturing of Cancer Cells

Current Issues in Molecular Biology, 2023
Cell culture is an important tool in biological research. Most studies use 2D cell culture, but cells grown in 2D cell culture have drawbacks, including limited cell and cell-extracellular matrix interactions, which make it inaccurate to model conditions
Novia Hanasti, Lia Faridah, Azzania Fibriani, Hesti Lina Wiraswati, Diah Kusumawaty, Savira Ekawardhani   +5 more
doaj   +1 more source

Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase

Stem Cell Research & Therapy, 2020
Background Generation of insulin-producing cells from human pluripotent stem cells (hPSCs) in vitro would be useful for drug discovery and cell therapy in diabetes.
Xiaofang Liu, Jinhua Qin, Mingyang Chang, Shuyong Wang, Yali Li, Xuetao Pei, Yunfang Wang   +6 more
doaj   +1 more source

3D cell culture model: From ground experiment to microgravity study

Frontiers in Bioengineering and Biotechnology, 2023
Microgravity has been shown to induce many changes in cell growth and differentiation due to offloading the gravitational strain normally exerted on cells.
Chiyuan Ma, Chiyuan Ma, Xianglong Duan, Xianglong Duan, Xiaohua Lei   +4 more
doaj   +1 more source

Data of a fluorescent imaging-based analysis of anti-cancer drug effects on three-dimensional cultures of breast cancer cells

Data in Brief, 2015
Three-dimensional (3D) cell culture is a powerful tool to study cell growth under 3D condition. To perform a simple test for anti-cancer drugs in 3D culture, visualization of non-proliferated cells is required.
Junji Itou, Sunao Tanaka, Wenzhao Li, Yoshiaki Matsumoto, Fumiaki Sato, Masakazu Toi   +5 more
doaj   +1 more source