Results 71 to 80 of about 6,641 (226)
Autologous induced pluripotent stem cell-derived four-organ-chip
Future Science OA, 2019 Microphysiological systems play a pivotal role in progressing toward a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents. All four organ models
Anja Patricia Ramme +17 more
doaj +1 more source
Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans [PDF]
, 2015 Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and other insults.
Bakan, Ahmet +14 more
core +1 more source
Advanced Healthcare Materials, EarlyView.A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen +9 more
wiley +1 more source
Engineering human spinal microphysiological systems to model opioid-induced tolerance
Bioactive Materials, 2023 pioids are commonly used for treating chronic pain. However, with continued use, they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy.
Hongwei Cai +9 more
doaj +1 more source
An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids
Advanced Materials Technologies, EarlyView.This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto +6 more
wiley +1 more source
Complex or not too complex? One size does not fit all in next generation microphysiological systems
iScienceSummary: In the attempt to overcome the increasingly recognized shortcomings of existing in vitro and in vivo models, researchers have started to implement alternative models, including microphysiological systems.
Simone Bersini +4 more
doaj +1 more source
Advanced Science, EarlyView.A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie +7 more
wiley +1 more source
Models of Renal Cell Carcinoma Used to Investigate Molecular Mechanisms and Develop New Therapeutics
Frontiers in Oncology, 2022 Modeling renal cell carcinoma is critical to investigating tumor biology and therapeutic mechanisms. Multiple systems have been developed to represent critical components of the tumor and its surrounding microenvironment.
Daniel D. Shapiro +6 more
doaj +1 more source
Microfabricated Physiological Models for In Vitro Drug Screening Applications [PDF]
, 2016 Microfluidics and microfabrication have recently been established as promising tools for developing a new generation of in vitro cell culture microdevices.
Cruz Moreira, Catia Daniela +4 more
core +2 more sources
The Development of Controllable Magnetic Driven Microphysiological System [PDF]
Frontiers in Cell and Developmental Biology, 2019 Current research has enabled the use of microphysiological systems and creation of models for alveolar and pulmonary diseases. However, bottlenecks remain in terms of medium- and long-term regulation of cell cultures and their functions in microchannel systems, as well as in the enhancement of in vitro representation of alveolar models and reference ...
Jia-Wei Yang +19 more
openaire +3 more sources