Results 81 to 90 of about 6,641 (226)

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Potential value of animal microphysiological systems

ALTEX
Microphysiological systems (MPS) are designed to recapitulate aspects of tissue/organ physiology in vivo, thereby providing potential value in safety and efficacy assessments of FDA-regulated products and regulatory decision-making. While there have been significant advances in the development, use, and proposals of qualification criteria for human ...
Paul C, Brown, Barry H, Hooberman, Brianna L, Skinner, Claudia, Wrzesinski, Dayton M, Petibone, Kevin A, Ford, Kristi L, Muldoon-Jacobs, Kyung E, Sung, Luis G, Valerio, Nakissa N, Sadrieh, Paul C, Howard, Peter L, Goering, Shelby A, Skoog, Suzanne C, Fitzpatrick, Tracy, Chen, Tracy C, MacGill, Donna L, Mendrick   +16 more
openaire   +2 more sources

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Organs-on-Chips Platforms Are Everywhere: A Zoom on Biomedical Investigation

Bioengineering, 2022
Over the decades, conventional in vitro culture systems and animal models have been used to study physiology, nutrient or drug metabolisms including mechanical and physiopathological aspects.
Mohamed Zommiti, Nathalie Connil, Ali Tahrioui, Anne Groboillot, Corinne Barbey, Yoan Konto-Ghiorghi, Olivier Lesouhaitier, Sylvie Chevalier, Marc G. J. Feuilloley   +8 more
doaj   +1 more source

The Price of Progress: Funding and Financing Alzheimer\u27s Disease Drug Development [PDF]

, 2018
Introduction Advancing research and treatment for Alzheimer\u27s disease (AD) and the search for effective treatments depend on a complex financial ecosystem involving federal, state, industry, advocacy, venture capital, and philanthropy funding ...
Cummings, Jeffrey, Kumar, Parvesh, Reiber, Carl   +2 more
core   +2 more sources

Advances of sacrificial strategies in additive manufacturing: towards precision 3D architectures and broad material adaptability

International Journal of Extreme Manufacturing
The pursuit of 3D structures with precise microarchitectures and broad material adaptability has long been a central scientific objective, given their transformative potential to tackle critical challenges across applications such as vascular networks ...
Wenwan Shi, Ming Gao, Xin Zhou, Xiaolu Sun, Haibo Ding, Yuning Zhou, Shuheng Li, Jing Sun, Xiaoxiang Gao, Xiaojiang Liu, Zhongze Gu   +10 more
doaj   +1 more source

Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip

Frontiers in Cell and Developmental Biology
Background: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function.
Jae Hee Byeon, Da Jung Jung, Hyo-Jeong Han, Woo-Chan Son, Gi Seok Jeong, Gi Seok Jeong   +5 more
doaj   +1 more source

Applying Proteomics to Study Crosstalk at the Cartilage-Subchondral Bone Interface in Osteoarthritis: current Status and Future Directions [PDF]

, 2018
K
Fellows, Christopher R., Matta, Csaba, Mobasheri, Ali   +2 more
core   +1 more source

Multi-scale cellular engineering: From molecules to organ-on-a-chip. [PDF]

, 2020
Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems.
Cahan, Patrick, Chaudhuri, Ovijit, Engler, Adam J, Huang, Ngan F, Khademhosseini, Ali, Kumar, Sanjay, Li, Song, Wang, Aijun, Wang, Yingxiao   +8 more
core   +2 more sources