Results 101 to 110 of about 8,980,611 (179)
A multi-organ microphysiological system for radiopharmaceutical biodistribution studies
Current Directions in Biomedical EngineeringRadiopharmaceuticals play a crucial role in positron emission tomography for diagnostic imaging and targeted cancer therapy. Their biodistribution and metabolism must be thoroughly characterized during preclinical development.
Petzold Mandy +6 more
doaj +1 more source
Microphysiological systems as models for immunologically ‘cold’ tumors
Frontiers in Cell and Developmental BiologyThe tumor microenvironment (TME) is a diverse milieu of cells including cancerous and non-cancerous cells such as fibroblasts, pericytes, endothelial cells and immune cells.
Daniela Gaebler +3 more
doaj +1 more source
Advanced Materials Technologies, Volume 11, Issue 19, 7 October 2026.A collagen‐based gut‐on‐chip model replicates the intestinal extracellular matrix, supporting villi‐like structures, tight junctions, and mucin production. This biomimetic platform enables rapid epithelial differentiation and functional barrier formation.
Fernanda López García +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 55, 5 October 2026.Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang +9 more
wiley +1 more source
3D organ-on-a-chip: the convergence of microphysiological systems and organoids
Medicine today faces the combined challenge of an increasing number of untreatable diseases and fewer drugs reaching the clinic. While pharmaceutical companies have increased the number of drugs in early development and entering phase I of clinical ...
Leandra S Baptista (18062972) +4 more
core +3 more sources
On-Chip AC Electrothermal Pump for Pulsatile Perfusion
MicromachinesMicrophysiological systems (MPSs) have emerged as promising platforms for drug discovery and in vitro pharmacological testing. MPSs aid to reproduce physiologically relevant microenvironments, in which controlled perfusion can play important role.
Itaru Kawata +3 more
doaj +1 more source
Vascularized joint‐on‐a‐chip: A paradigm shift for arthritis pathophysiology and clinical treatment
Rheumatology &Autoimmunity, EarlyView.
Danli Cui +6 more
wiley +1 more source
Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.Intermittent catheter use can damage the urinary tract and predispose to infection. We deployed a complex human urothelial model to investigate. Catheter contact induced compressive and shear stress causing umbrella cell disruption, reduced barrier function, inflammation and increased cell adhesion to the catheter surface.
Nazila V. Jafari, Jennifer L. Rohn
wiley +1 more source
AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics
Advanced Intelligent SystemsNanoparticles (NPs) play a critical role in applications ranging from medicine to materials science, requiring precise control of properties, such as size, shape, and surface chemistry.
Yedam Lee +3 more
doaj +1 more source
Advanced Cellular Models for Neurodegenerative Diseases and PFAS-Related Environmental Risks
NeuroSciPer- and polyfluoroalkyl substances are persistent environmental contaminants increasingly implicated in neurotoxicity. Establishing causality and mechanisms relevant to Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis requires human ...
Davide Rotondo +3 more
doaj +1 more source