Results 1 to 10 of about 4,385 (152)

Assessment of drug permeability using a small airway microphysiological system [PDF]

Frontiers in Pharmacology
BackgroundThere is a need to reliably predict the permeability of inhaled compounds during the development of new and generic drugs. A small airway microphysiological system (MPS) that can recapitulate the pulmonary air-liquid interface (ALI) with ...
Robert M. Geiger, Shekh M. Rahman, Md Shadiqur Rashid Roni, Catherine Sullenberger, Sabyasachy Mistry, Katherine Shea, Isra Tariq, Omnia A. Ismaiel, Murali K. Matta, Paula L. Hyland, Sasha Berdichevski, Sasha Berdichevski, Alexandre J. S. Ribeiro, Ksenia Blinova, Wenlei Jiang, Ross L. Walenga, Bryan Newman, Donna A. Volpe, Kevin A. Ford   +18 more
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Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform [PDF]

Experimental Biology and Medicine
The advancement in the use of all-human high content microphysiological systems (MPS) has enabled better in vitro modeling of liver function and disease progression as well as drug efficacy, metabolism and toxicity (ADME-Tox) testing.
Dillon C. Gavlock, Michael W. Castiglione, Allen Wang, Mahboubeh Varmazyad, Mahboubeh Varmazyad, Mahboubeh Varmazyad, Lawrence A. Vernetti, Lawrence A. Vernetti, Lawrence A. Vernetti, Mark E. Schurdak, Mark E. Schurdak, Mark E. Schurdak, D. Lansing Taylor, D. Lansing Taylor, D. Lansing Taylor, Jacquelyn A. Brown, Jacquelyn A. Brown, Jacquelyn A. Brown, Mark T. Miedel, Mark T. Miedel, Mark T. Miedel   +20 more
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Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening

Bioactive Materials
Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the ...
Yuxuan Zhu, Deming Jiang, Yong Qiu, Xin Liu, Yuhan Bian, Shichao Tian, Xiandi Wang, K. Jimmy Hsia, Hao Wan, Liujing Zhuang, Ping Wang   +10 more
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Material-dependent oxygen transport governs ischemia-reperfusion injury and drug response in a kidney microphysiological system [PDF]

Frontiers in Toxicology
Oxygen availability is a critical yet often overlooked factor in cell culture, and discrepancies between nominal oxygen settings and the actual cellular microenvironment can compromise model validity.
Naokata Kutsuzawa, Naokata Kutsuzawa, Hiroko Nakamura, Kenta Shinha, Hiroshi Kimura   +4 more
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An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery [PDF]

Microsystems & Nanoengineering
Physiological supporting systems, such as the vascular network and excretion system, are crucial for the effective functioning of organs. This study demonstrates that when a body-on-a-chip microdevice is coupled with miniaturized physiological support ...
Jing Wang, Huixue Zhang, Yueyang Qu, Yang Yang, Shuhui Xu, Zhenni Ji, Yuxiu Wang, Xiuli Zhang, Yong Luo   +8 more
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Engineering a Human Pluripotent Stem Cell-Based in vitro Microphysiological System for Studying the Metformin Response in Aortic Smooth Muscle Cells

Frontiers in Bioengineering and Biotechnology, 2021
Aortic aneurysm is a common cardiovascular disease characterised by continuous dilation of the aorta, and this disease places a heavy burden on healthcare worldwide.
Nan Chen, Nan Chen, Mieradilijiang Abudupataer, Mieradilijiang Abudupataer, Sisi Feng, Shichao Zhu, Shichao Zhu, Wenrui Ma, Wenrui Ma, Jun Li, Jun Li, Hao Lai, Hao Lai, Kai Zhu, Kai Zhu, Chunsheng Wang, Chunsheng Wang   +16 more
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Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system

Nano Convergence, 2021
Hepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure, and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in excessive extracellular matrix deposition and hepatic ...
Hafiz Muhammad Umer Farooqi, Bohye Kang, Muhammad Asad Ullah Khalid, Abdul Rahim Chethikkattuveli Salih, Kinam Hyun, Sung Hyuk Park, Dongeun Huh, Kyung Hyun Choi   +7 more
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Modular Microphysiological System for Modeling of Biologic Barrier Function

Frontiers in Bioengineering and Biotechnology, 2020
Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,
Matthew Ishahak, Jordan Hill, Quratulain Amin, Laura Wubker, Adiel Hernandez, Alla Mitrofanova, Alexis Sloan, Alessia Fornoni, Alessia Fornoni, Ashutosh Agarwal, Ashutosh Agarwal   +10 more
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Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease

Nature Communications, 2022
In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules. Here the authors show that subjecting organoids to fluid shear stress in a PKD-on-a-chip microphysiological system promotes cyst expansion via an absorptive pathway.
Sienna R. Li, Ramila E. Gulieva, Louisa Helms, Nelly M. Cruz, Thomas Vincent, Hongxia Fu, Jonathan Himmelfarb, Benjamin S. Freedman   +7 more
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Human Mesenchymal Stem Cell‐Derived Miniature Joint System for Disease Modeling and Drug Testing

Advanced Science, 2022
Diseases of the knee joint such as osteoarthritis (OA) affect all joint elements. An in vitro human cell‐derived microphysiological system capable of simulating intraarticular tissue crosstalk is desirable for studying etiologies/pathogenesis of joint ...
Zhong Li, Zixuan Lin, Silvia Liu, Haruyo Yagi, Xiurui Zhang, Lauren Yocum, Monica Romero‐Lopez, Claire Rhee, Meagan J. Makarcyzk, Ilhan Yu, Eileen N. Li, Madalyn R. Fritch, Qi Gao, Kek Boon Goh, Benjamen O'Donnell, Tingjun Hao, Peter G. Alexander, Bhushan Mahadik, John P. Fisher, Stuart B. Goodman, Bruce A. Bunnell, Rocky S. Tuan, Hang Lin   +22 more
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