Results 1 to 10 of about 3,866 (113)

Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform [PDF]

Experimental Biology and Medicine
The advancement in the use of all-human high content microphysiological systems (MPS) has enabled better in vitro modeling of liver function and disease progression as well as drug efficacy, metabolism and toxicity (ADME-Tox) testing.
Dillon C. Gavlock, Michael W. Castiglione, Allen Wang, Mahboubeh Varmazyad, Mahboubeh Varmazyad, Mahboubeh Varmazyad, Lawrence A. Vernetti, Lawrence A. Vernetti, Lawrence A. Vernetti, Mark E. Schurdak, Mark E. Schurdak, Mark E. Schurdak, D. Lansing Taylor, D. Lansing Taylor, D. Lansing Taylor, Jacquelyn A. Brown, Jacquelyn A. Brown, Jacquelyn A. Brown, Mark T. Miedel, Mark T. Miedel, Mark T. Miedel   +20 more
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Modular Microphysiological System for Modeling of Biologic Barrier Function

Frontiers in Bioengineering and Biotechnology, 2020
Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,
Matthew Ishahak, Jordan Hill, Quratulain Amin, Laura Wubker, Adiel Hernandez, Alla Mitrofanova, Alexis Sloan, Alessia Fornoni, Alessia Fornoni, Ashutosh Agarwal, Ashutosh Agarwal   +10 more
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Assessment of drug permeability using a small airway microphysiological system [PDF]

Frontiers in Pharmacology
BackgroundThere is a need to reliably predict the permeability of inhaled compounds during the development of new and generic drugs. A small airway microphysiological system (MPS) that can recapitulate the pulmonary air-liquid interface (ALI) with ...
Robert M. Geiger, Shekh M. Rahman, Md Shadiqur Rashid Roni, Catherine Sullenberger, Sabyasachy Mistry, Katherine Shea, Isra Tariq, Omnia A. Ismaiel, Murali K. Matta, Paula L. Hyland, Sasha Berdichevski, Sasha Berdichevski, Alexandre J. S. Ribeiro, Ksenia Blinova, Wenlei Jiang, Ross L. Walenga, Bryan Newman, Donna A. Volpe, Kevin A. Ford   +18 more
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Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening

Bioactive Materials
Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the ...
Yuxuan Zhu, Deming Jiang, Yong Qiu, Xin Liu, Yuhan Bian, Shichao Tian, Xiandi Wang, K. Jimmy Hsia, Hao Wan, Liujing Zhuang, Ping Wang   +10 more
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An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery [PDF]

Microsystems & Nanoengineering
Physiological supporting systems, such as the vascular network and excretion system, are crucial for the effective functioning of organs. This study demonstrates that when a body-on-a-chip microdevice is coupled with miniaturized physiological support ...
Jing Wang, Huixue Zhang, Yueyang Qu, Yang Yang, Shuhui Xu, Zhenni Ji, Yuxiu Wang, Xiuli Zhang, Yong Luo   +8 more
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Modeling lung endothelial dysfunction in sepsis‐associated ARDS using a microphysiological system [PDF]

Physiological Reports
Endothelial dysfunction is a critical feature of acute respiratory distress syndrome (ARDS) associated with higher disease severity and worse outcomes. Preclinical in vivo models of sepsis and ARDS have failed to yield useful therapies in humans, perhaps
Nai‐Wen Liang, Carole Wilson, Brooke Davis, Ian Wolf, Tonela Qyli, Joy Moy, David J. Beebe, Lynn M. Schnapp, Sheena C. Kerr, Hilary E. Faust   +9 more
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Evaluation of Perfusion Cell Culture Conditions in a Double-Layered Microphysiological System Using AI-Assisted Morphological Analysis [PDF]

Micromachines
In recent years, microphysiological systems (MPS) using microfluidic technology as a new in vitro experimental system have shown promise as an alternative to animal experiments in the development of drugs, especially in the field of drug discovery, and ...
Naokata Kutsuzawa, Tomomi Goto, Hiroko Nakamura, Miwa Maeda, Masaki Kinehara, Junko Sakagami, Hiroshi Kimura   +6 more
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Engineering a Human Pluripotent Stem Cell-Based in vitro Microphysiological System for Studying the Metformin Response in Aortic Smooth Muscle Cells

Frontiers in Bioengineering and Biotechnology, 2021
Aortic aneurysm is a common cardiovascular disease characterised by continuous dilation of the aorta, and this disease places a heavy burden on healthcare worldwide.
Nan Chen, Nan Chen, Mieradilijiang Abudupataer, Mieradilijiang Abudupataer, Sisi Feng, Shichao Zhu, Shichao Zhu, Wenrui Ma, Wenrui Ma, Jun Li, Jun Li, Hao Lai, Hao Lai, Kai Zhu, Kai Zhu, Chunsheng Wang, Chunsheng Wang   +16 more
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Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system

Nano Convergence, 2021
Hepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure, and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in excessive extracellular matrix deposition and hepatic ...
Hafiz Muhammad Umer Farooqi, Bohye Kang, Muhammad Asad Ullah Khalid, Abdul Rahim Chethikkattuveli Salih, Kinam Hyun, Sung Hyuk Park, Dongeun Huh, Kyung Hyun Choi   +7 more
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Mera: A scalable high throughput automated micro-physiological system

SLAS Technology, 2023
There is an urgent need for scalable Microphysiological Systems (MPS's)11 Microphysiological systems (MPSs), Microtissue (MT), Polyetheretherketone (PEEK), Polytetrafluoroethylene (PTFE), Polystyrene (PS) that can better predict drug efficacy and ...
Finola E. Cliffe, Conor Madden, Patrick Costello, Shane Devitt, Sumir Ramesh Mukkunda, Bhairavi Bengaluru Keshava, Howard O. Fearnhead, Aiste Vitkauskaite, Mahshid H. Dehkordi, Walter Chingwaru, Milosz Przyjalgowski, Natalia Rebrova, Mark Lyons   +12 more
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