Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems [PDF]
, 2017 Liver disease represents a growing global health burden. The development of in vitro liver models which allow the study of disease and the prediction of metabolism and drug-induced liver injury in humans remains a challenge.
David J Hughes +2 more
core +1 more source
Microphysiologic systems in female reproductive biology [PDF]
Experimental Biology and Medicine, 2017 Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a ...
Alexandria N, Young +3 more
openaire +2 more sources
Rapid Prototyping of Multilayer Microphysiological Systems
ACS Biomaterials Science & Engineering, 2020 Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared to traditional two-dimensional (2D) static cell culture. Often such devices are fabricated via poly(dimethylsiloxane) (PDMS) soft lithography, which offers benefits (e.g., high feature resolution) along with drawbacks (e.g., prototyping time/costs).
Sanjin Hosic +9 more
openaire +3 more sources
Autologous induced pluripotent stem cell-derived four-organ-chip
Future Science OA, 2019 Microphysiological systems play a pivotal role in progressing toward a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents. All four organ models
Anja Patricia Ramme +17 more
doaj +1 more source
Recent Advances in the Gastrointestinal Complex in Vitro Model for ADME Studies
Pharmaceutics, 2023 Intestinal absorption is a complex process involving the permeability of the epithelial barrier, efflux transporter activity, and intestinal metabolism.
Kazuyoshi Michiba +3 more
doaj +1 more source
Organoids pharmacology and toxicology
EngMedicineModel evolution is crucial for understanding the effects and safety of drugs in pharmacological and toxicological research. Traditional cell lines and animal models have contributed significantly to drug development.
Jie Sun +7 more
doaj +1 more source
Demineralized bone bioinks with enhanced odontogenic differentiation: Synthesis and characterization
Polymer TestingWe developed a photocrosslinkable hydrogel, DbpGMA, by chemically functionalizing demineralized bone powder (DBP) with glycidyl methacrylate (GMA). Bone particles smaller than 90 μm effectively preserved the collagenous matrix after demineralization ...
Sudarshini Nath +12 more
doaj +1 more source
Development of a Perfusing Small Intestine–Liver Microphysiological System Device [PDF]
, 2023 There is an increasing need to develop alternatives to animal modeling and testing for pre-clinical studies as researchers face major challenges, such as the study of dynamic systems in laboratory settings.
Isao Saito +6 more
core +1 more source
Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip
Frontiers in Cell and Developmental BiologyBackground: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function.
Jae Hee Byeon +5 more
doaj +1 more source
Vascular Microphysiological System for Investigating Endothelial Barrier Function During Organ Preservation and Reperfusion. [PDF]
SmallEndothelial cell damage after cold preservation and reperfusion injury causes deterioration of the endothelial barrier and ultimately results in edema, leading to transplant failure.
Kim Y +14 more
europepmc +3 more sources