Results 31 to 40 of about 17,314,856 (225)

Demineralized bone bioinks with enhanced odontogenic differentiation: Synthesis and characterization

Polymer Testing
We developed a photocrosslinkable hydrogel, DbpGMA, by chemically functionalizing demineralized bone powder (DBP) with glycidyl methacrylate (GMA). Bone particles smaller than 90 μm effectively preserved the collagenous matrix after demineralization ...
Sudarshini Nath, Heesun Hong, Ji-Hyun Jang, Moon Sik Oh, Sol Kim, Ok Joo Lee, Ji Seung Lee, Kyunghee Kim, Chul Hee Lee, Ki Hyun Kim, Yusang Son, Chan Hum Park, Soon Hee Kim   +12 more
doaj   +1 more source

Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip

Frontiers in Cell and Developmental Biology
Background: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function.
Jae Hee Byeon, Da Jung Jung, Hyo-Jeong Han, Woo-Chan Son, Gi Seok Jeong, Gi Seok Jeong   +5 more
doaj   +1 more source

Rapid Prototyping of Multilayer Microphysiological Systems

ACS Biomaterials Science & Engineering, 2020
Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared to traditional two-dimensional (2D) static cell culture. Often such devices are fabricated via poly(dimethylsiloxane) (PDMS) soft lithography, which offers benefits (e.g., high feature resolution) along with drawbacks (e.g., prototyping time/costs).
Sanjin Hosic, Adam J. Bindas, Marissa L. Puzan, Will Lake, Jonathan R. Soucy, Fanny Zhou, Ryan A. Koppes, David T. Breault, Shashi K. Murthy, Abigail N. Koppes   +9 more
openaire   +3 more sources

A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties

, 2018
Distant metastasis is the major cause of breast cancer-related mortality, commonly emerging clinically after 5 or more years of seeming 'cure'of the primary tumor, indicating a quiescent dormancy.
Griffith, Linda G, Wheeler, S. E., Stolz, D. B., Young, Carissa L., Clark, Abigail M, Stockdale, Linda, Wells, A., Shepard, Nieman J., Zhao, Weian, Lauffenburger, Douglas A, Venkataramanan, R.   +10 more
core   +1 more source

Breast Cancer Reconstruction: Design Criteria for a Humanized Microphysiological System

, 2021
International regulatory agencies such as the Food and Drug Administration have mandated that the scientific community develop humanized microphysiological systems (MPS) as an alternative to animal models in the near future.
Frazier, Trivia, Rogers, Emma, Williams, Christopher, Hamel, Katie, Henderson, Michael, Duplessis, Tamika, Wu, Xiying   +6 more
core   +2 more sources

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Microphysiological system for heart tissue - going from 2D to 3D culture

Current Directions in Biomedical Engineering, 2019
Recently, we could demonstrate positive effects of microfluidic cultivation conditions on maturation of cardiomyocytes derived from human induced pluripotent stem cells (iPS-CMs) in a 2D model.
Busek Mathias, Schubert Mario, Guan Kaomei, Sonntag Frank, Schmieder Florian, Marschner Uwe, Richter Andreas   +6 more
doaj   +1 more source

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

Engineering Organ-on-a-Chip to Accelerate Translational Research

Micromachines, 2022
We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a form of microengineered cell culture platform that elaborates the in-vivo like organ or tissue microenvironments.
Jihoon Ko, Dohyun Park, Somin Lee, Burcu Gumuscu, Noo Li Jeon   +4 more
doaj   +1 more source

Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics

Advanced Science, EarlyView.
Brain organoids are emerging as increasingly functional human‐relevant platforms, yet limitations in vascularization, maturation, measurement, and reproducibility still constrain their translational value. This Perspective examines how microfluidics, biofabrication, advanced imaging, electrophysiology, multimodal AI, standardization, and ethical ...
Aishwarya Pantula, Kaustubh Joshi, Swarangi Samant, Greta Babakhanova, Annie Kathuria   +4 more
wiley   +1 more source