Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells [PDF]
, 2015 Purpose: The lung is one of the most common sites of breast cancer metastasis. While metastatic seeding is often accompanied by a dormancy-promoting mesenchymal to epithelial reverting transitions (MErT), we aimed to determine whether lung epithelial ...
Clark, AM +3 more
core +7 more sources
Human Mesenchymal Stem Cell‐Derived Miniature Joint System for Disease Modeling and Drug Testing
Advanced Science, 2022 Diseases of the knee joint such as osteoarthritis (OA) affect all joint elements. An in vitro human cell‐derived microphysiological system capable of simulating intraarticular tissue crosstalk is desirable for studying etiologies/pathogenesis of joint ...
Zhong Li +22 more
doaj +1 more source
In vitro tissue microarrays for quick and efficient spheroid characterisation [PDF]
, 2018 Three-dimensional in vitro microphysiological cultures, such as spheroids and organoids, promise increased patient relevance and therapeutic predictivity compared to reductionist cell monolayers.
A. M. Grabowska, D. P. Ivanov, Subik K.
core +2 more sources
Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration [PDF]
, 2015 Our goal in developing Microphysiological Systems (MPS) technology is to provide an improved approach for more predictive preclinical drug discovery via a highly integrated experimental/computational paradigm.
Cilfone, Nicholas A. +10 more
core +1 more source
Stem cell-based vascularization of microphysiological systems [PDF]
Stem Cell Reports, 2021 Microphysiological systems (MPSs) (i.e., tissue or organ chips) exploit microfluidics and 3D cell culture to mimic tissue and organ-level physiology. The advent of human induced pluripotent stem cell (hiPSC) technology has accelerated the use of MPSs to study human disease in a range of organ systems. However, in the reduction of system complexity, the
Browne, Shane +4 more
openaire +4 more sources
Maximizing the Impact of Microphysiological Systems with in Vitro–in Vivo Translation [PDF]
, 2018 Microphysiological systems (MPS) hold promise for improving therapeutic drug approval rates by providing more physiological, human-based, in vitro assays for preclinical drug development activities compared to traditional in vitro and animal models. Here,
Cirit, Murat, Stokes, Cynthia L.
core +1 more source
Microphysiologic systems in female reproductive biology [PDF]
Experimental Biology and Medicine, 2017 Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a
Alexandria N, Young +3 more
openaire +2 more sources
Autologous induced pluripotent stem cell-derived four-organ-chip
Future Science OA, 2019 Microphysiological systems play a pivotal role in progressing toward a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents. All four organ models
Anja Patricia Ramme +17 more
doaj +1 more source
Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused 3D human liver bioreactor [PDF]
, 2015 Endotoxin lipopolysaccharide (LPS) is known to cause liver injury primarily involving inflammatory cells such as Kupffer cells, but few in vitro culture models are applicable for investigation of inflammatory effects on drug metabolism. We have developed
Dyer, Rachel Lee +9 more
core +1 more source
Rapid Prototyping of Multilayer Microphysiological Systems
ACS Biomaterials Science & Engineering, 2020 Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared to traditional two-dimensional (2D) static cell culture. Often such devices are fabricated via poly(dimethylsiloxane) (PDMS) soft lithography, which offers benefits (e.g., high feature resolution) along with drawbacks (e.g., prototyping time/costs).
Sanjin Hosic +9 more
openaire +3 more sources