Results 41 to 50 of about 17,314,856 (225)
Advanced Science, EarlyView.A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li +9 more
wiley +1 more source
Advanced Science, EarlyView.A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen +15 more
wiley +1 more source
Autologous induced pluripotent stem cell-derived four-organ-chip
Future Science OA, 2019 Microphysiological systems play a pivotal role in progressing toward a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents. All four organ models
Anja Patricia Ramme +17 more
doaj +1 more source
Neuromorphic Devices and Computing for Sensing, Memory, and Control
Advanced Science, EarlyView.This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu +2 more
wiley +1 more source
, 2018 In this work, we first describe the population variability in hepatic drug metabolism using cryopreserved hepatocytes from five different donors cultured in a perfused three-dimensional human liver microphysiological system, and then show how the ...
Griffith, Linda G +5 more
core +1 more source
Light-triggered cardiac microphysiological model [PDF]
, 2023 Light is recognized as an accurate and noninvasive tool for stimulating excitable cells. Here, we report on a non-genetic approach based on organic molecular phototransducers that allows wiring- and electrode-free tissue modulation. As a proof of concept,
Lanzani, G +23 more
core +1 more source
Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System
Advanced Electronic MaterialsMicrophysiological systems hold great potential for fundamental discovery and accelerating the drug discovery pipeline through simplifying complex tissues to their first principles and enabling real‐time, high‐resolution monitoring.
Dominic Pizzarella +4 more
doaj +1 more source
The Development of Controllable Magnetic Driven Microphysiological System
Frontiers in Cell and Developmental Biology, 2019 Current research has enabled the use of microphysiological systems and creation of models for alveolar and pulmonary diseases. However, bottlenecks remain in terms of medium- and long-term regulation of cell cultures and their functions in microchannel ...
Jia-Wei Yang +19 more
doaj +1 more source
Advanced Science, EarlyView.A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang +5 more
wiley +1 more source
Human in vitro endometriosis microphysiological system
Current Directions in Biomedical EngineeringEndometriosis is a debilitating condition that causes severe pain and infertility, among other morbidities. It affects 10% of reproductive-aged women worldwide and poses a significant public health challenge due to its prevalence and the lack of ...
Pinheiro Marques Joao +5 more
doaj +1 more source