Results 41 to 50 of about 6,388 (235)
Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]
, 2020 Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony +3 more
core +1 more source
Gut Microbes, 2020 A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-microbiome interactions in vitro.
Woojung Shin +2 more
doaj +1 more source
, 2018 © 2017 The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases.
Beckwitt, Colin H. +6 more
core +1 more source
Organoids pharmacology and toxicology
EngMedicineModel evolution is crucial for understanding the effects and safety of drugs in pharmacological and toxicological research. Traditional cell lines and animal models have contributed significantly to drug development.
Jie Sun +7 more
doaj +1 more source
The Dormancy Dilemma: Quiescence versus Balanced Proliferation [PDF]
, 2013 Metastatic dissemination with subsequent clinical outgrowth leads to the greatest part of morbidity and mortality from most solid tumors. Even more daunting is that many of these metastatic deposits silently lie undetected, recurring years to decades ...
Griffith, Linda G. +3 more
core +2 more sources
Demineralized bone bioinks with enhanced odontogenic differentiation: Synthesis and characterization
Polymer TestingWe developed a photocrosslinkable hydrogel, DbpGMA, by chemically functionalizing demineralized bone powder (DBP) with glycidyl methacrylate (GMA). Bone particles smaller than 90 μm effectively preserved the collagenous matrix after demineralization ...
Sudarshini Nath +12 more
doaj +1 more source
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents [PDF]
, 2015 Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied substances
Bauer, Sophie +13 more
core +1 more source
Engineering Organ-on-a-Chip to Accelerate Translational Research
Micromachines, 2022 We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a form of microengineered cell culture platform that elaborates the in-vivo like organ or tissue microenvironments.
Jihoon Ko +4 more
doaj +1 more source
Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip
Frontiers in Cell and Developmental BiologyBackground: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function.
Jae Hee Byeon +5 more
doaj +1 more source
Microphysiological Systems: Design, Fabrication, and Applications
ACS Biomaterials Science & Engineering, 2020 Microphysiological systems, including organoids, 3-D printed tissue constructs and organ-on-a-chips (organ chips), are physiologically relevant in vitro models and have experienced explosive growth in the past decades. Different from conventional, tissue culture plastic-based in vitro models or animal models, microphysiological systems recapitulate key
Kai Wang +6 more
openaire +3 more sources