Results 61 to 70 of about 6,388 (235)
Advanced Healthcare Materials, EarlyView.A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen +9 more
wiley +1 more source
, 2013 Interest in “engineering liver” arises from multiple communities: therapeutic replacement; mechanistic models of human processes; and drug safety and efficacy studies.
Griffith, Linda G. +2 more
core +1 more source
An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids
Advanced Materials Technologies, EarlyView.This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto +6 more
wiley +1 more source
Human in vitro endometriosis microphysiological system
Current Directions in Biomedical EngineeringEndometriosis is a debilitating condition that causes severe pain and infertility, among other morbidities. It affects 10% of reproductive-aged women worldwide and poses a significant public health challenge due to its prevalence and the lack of ...
Pinheiro Marques Joao +5 more
doaj +1 more source
Organoids and Microphysiological Systems: New Tools for Ophthalmic Drug Discovery
Frontiers in Pharmacology, 2020 Organoids are adept at preserving the inherent complexity of a given cellular environment and when integrated with engineered micro-physiological systems (MPS) present distinct advantages for simulating a precisely controlled geometrical, physical, and ...
Jing Bai, Chunming Wang
doaj +1 more source
The Price of Progress: Funding and Financing Alzheimer\u27s Disease Drug Development [PDF]
, 2018 Introduction Advancing research and treatment for Alzheimer\u27s disease (AD) and the search for effective treatments depend on a complex financial ecosystem involving federal, state, industry, advocacy, venture capital, and philanthropy funding ...
Cummings, Jeffrey +2 more
core +2 more sources
Advanced Science, EarlyView.A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie +7 more
wiley +1 more source
Applying Proteomics to Study Crosstalk at the Cartilage-Subchondral Bone Interface in Osteoarthritis: current Status and Future Directions [PDF]
, 2018 K
Fellows, Christopher R. +2 more
core +1 more source
Modelling the innate immune system in microphysiological systems
Lab on a ChipIntegration of an immune component moves the field closer to a physiologically relevant human-on-a-chip.
Michael J. Rupar +5 more
openaire +2 more sources
Advanced Science, EarlyView.A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min +6 more
wiley +1 more source