Results 61 to 70 of about 17,314,856 (225)

“Good Fences Make Good Neighbors”: How does the Human Gut Microchip Unravel Mechanism of Intestinal Inflammation?

Gut Microbes, 2020
A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-microbiome interactions in vitro.
Woojung Shin, Landon A. Hackley, Hyun Jung Kim   +2 more
doaj   +1 more source

Organoids and Microphysiological Systems: New Tools for Ophthalmic Drug Discovery

Frontiers in Pharmacology, 2020
Organoids are adept at preserving the inherent complexity of a given cellular environment and when integrated with engineered micro-physiological systems (MPS) present distinct advantages for simulating a precisely controlled geometrical, physical, and ...
Jing Bai, Chunming Wang
doaj   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

A microphysiological systems approach to design gastrointestinal system

Journal of Biomaterials Science, Polymer Edition
The gastrointestinal (GI) system is a complex and dynamic organ system, with the anatomy and varied physiological functionality adding complexity to nutrient absorption, immune function, and maintenance of overall health. This review begins with an overview of the anatomy, highlighting key organs and their respective roles, followed by an exploration ...
Vidhi Mathur, Mrunmayi Gadre, Amrutha H. K., Kirthanashri S. Vasanthan   +3 more
openaire   +2 more sources

Laser-induced cell injury in closed microphysiological systems: A novel method to study regeneration processes

, 2022
S.S214Closed microphysiological systems are miniaturized, chip-sized platforms that can be used as cellularized organoid systems to study cellular processes like migration, regeneration or proliferation in-vitro.
Sradnick, Jan, Schmieder, Florian, Förster, Deborah, Hohenstein, Bernd, Sonntag, Frank   +4 more
core   +1 more source

Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip

Frontiers in Toxicology
Microphysiological systems (MPS) and Organs-on-Chips (OoCs) hold significant potential for replicating complex human biological processes in vitro. However, their widespread adoption by industry and regulatory bodies depends on effective qualification to
Huub J. Weener, Heleen H. T. Middelkamp, Heleen H. T. Middelkamp, Andries D. Van der Meer   +3 more
doaj   +1 more source

Long‐Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

Advanced Science, EarlyView.
An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma, Evelien Schaafsma, Elysia Anderson, Jocelyn Chiari, Paige Thompson, Erin Galt, Sunghoon Lee, Jason Holsapple, Sai Hein, Bailey L. Coates, Jade Michaud, Sabrina Zuccaro, Lia Kent, Chris Hinojosa, Kyung‐Jin Jang   +14 more
wiley   +1 more source

Potential value of animal microphysiological systems

ALTEX
Microphysiological systems (MPS) are designed to recapitulate aspects of tissue/organ physiology in vivo, thereby providing potential value in safety and efficacy assessments of FDA-regulated products and regulatory decision-making. While there have been significant advances in the development, use, and proposals of qualification criteria for human ...
Paul C, Brown, Barry H, Hooberman, Brianna L, Skinner, Claudia, Wrzesinski, Dayton M, Petibone, Kevin A, Ford, Kristi L, Muldoon-Jacobs, Kyung E, Sung, Luis G, Valerio, Nakissa N, Sadrieh, Paul C, Howard, Peter L, Goering, Shelby A, Skoog, Suzanne C, Fitzpatrick, Tracy, Chen, Tracy C, MacGill, Donna L, Mendrick   +16 more
openaire   +2 more sources

Mechanical stimulation and monitoring of artificial collagen membranes for Organ-on Chip applications

Current Directions in Biomedical Engineering
A novel tool to create artificial, cell-based model systems of biological barriers for preclinical drug testing and basic research are artificial collagen membranes (ACM).
Behrens Stephan, Golde Jonas, Schöps Yvo, Polk Christoph, Seidel Gloria, Goerke Felix, Sonntag Frank, Schmieder Florian   +7 more
doaj   +1 more source

Collagen concentration regulates neutrophil extravasation and migration in response to infection in an endothelium dependent manner

Frontiers in Immunology
IntroductionAs the body’s first line of defense against disease and infection, neutrophils must efficiently navigate to sites of inflammation; however, neutrophil dysregulation contributes to the pathogenesis of numerous diseases that leave people ...
Christopher J. Calo, Tanvi Patil, Mallory Palizzi, Nicola Wheeler, Laurel E. Hind   +4 more
doaj   +1 more source