Results 61 to 70 of about 4,549 (220)

Integrating an aerosolised drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system [PDF]

Dataset to support publication: Integrating an aerosolised drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system.
Swindle, Emily, Fernandes, Joao, Cabaco, Morgan, Hywel, Karra, Nikita   +3 more
core   +1 more source

In vitro microphysiological system for modeling vascular disease [PDF]

, 2018
In vitro microphysiological system utilizes engineered tissue constructs from human cells to model functional activity of human tissues or organs in both healthy and diseased state, thereby providing a more accurate drug screening than animal models ...
Ji, Hayeun
core   +2 more sources

Modelling the innate immune system in microphysiological systems

Lab on a Chip
Integration of an immune component moves the field closer to a physiologically relevant human-on-a-chip.
Michael J. Rupar, Hannah Hanson, Stephanie Rogers, Brianna Botlick, Steven Trimmer, James J. Hickman   +5 more
openaire   +2 more sources

Organoids and Microphysiological Systems: New Tools for Ophthalmic Drug Discovery

Frontiers in Pharmacology, 2020
Organoids are adept at preserving the inherent complexity of a given cellular environment and when integrated with engineered micro-physiological systems (MPS) present distinct advantages for simulating a precisely controlled geometrical, physical, and ...
Jing Bai, Chunming Wang
doaj   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Human Vascular Microphysiological Systems for Drug Screening [PDF]

, 2016
Endothelial dysfunction is the predominant pathophysiological state prior to the onset of atherosclerosis. Currently, treatments for endothelial dysfunction are evaluated in vitro using two-dimensional (2D) cell culture assays or in vivo animal models ...
Fernandez, Cristina Elena
core  

Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems [PDF]

, 2015
Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation.
Stokes, CL, Cirit, Murat, Lauffenburger, Douglas A   +2 more
core   +1 more source

“Good Fences Make Good Neighbors”: How does the Human Gut Microchip Unravel Mechanism of Intestinal Inflammation?

Gut Microbes, 2020
A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-microbiome interactions in vitro.
Woojung Shin, Landon A. Hackley, Hyun Jung Kim   +2 more
doaj   +1 more source

Super‐Resolution and High‐Data‐Density Acoustic Meta‐Hologram via Amplitude and Phase Coupling

Advanced Science, EarlyView.
A super‐resolution acoustic meta‐hologram utilizes amplitude‐phase coupling under energy conservation constraints to overcome the traditional diffraction limit. This conceptually advanced approach achieves high‐fidelity acoustic field reconstruction and dense information transmission, unlocking new potentials for high‐resolution acoustic imaging and ...
Xiao Guo, Xinzong Wang, Guoshen Tang, Haohan Zeng, Siqi Fan, Xinghao Hu, Youyu Mo, Zhenyu He, Tingting Li, Hui Xu, Jiao Shen, Haiyan Fan, Xiaoxiang Gao, Yifan Zhu, Hui Zhang, Badreddine Assouar   +15 more
wiley   +1 more source

Potential value of animal microphysiological systems

ALTEX
Microphysiological systems (MPS) are designed to recapitulate aspects of tissue/organ physiology in vivo, thereby providing potential value in safety and efficacy assessments of FDA-regulated products and regulatory decision-making. While there have been significant advances in the development, use, and proposals of qualification criteria for human ...
Paul C, Brown, Barry H, Hooberman, Brianna L, Skinner, Claudia, Wrzesinski, Dayton M, Petibone, Kevin A, Ford, Kristi L, Muldoon-Jacobs, Kyung E, Sung, Luis G, Valerio, Nakissa N, Sadrieh, Paul C, Howard, Peter L, Goering, Shelby A, Skoog, Suzanne C, Fitzpatrick, Tracy, Chen, Tracy C, MacGill, Donna L, Mendrick   +16 more
openaire   +2 more sources