Results 81 to 90 of about 6,388 (235)

Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans [PDF]

, 2015
Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and other insults.
Bakan, Ahmet, Bale, Shyam S, Berk Usta, O, Bhushan, Abhinav, Biasio, Richard, Golberg, Inna, Gough, Albert, Hegde, Manjunath, Jindal, Rohit, Lansing Taylor, D, McCarty, William J, Senutovitch, Nina, Shun, Tong Ying, Vernetti, Lawrence, Yarmush, Martin L   +14 more
core   +1 more source

Multi-scale cellular engineering: From molecules to organ-on-a-chip. [PDF]

, 2020
Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems.
Cahan, Patrick, Chaudhuri, Ovijit, Engler, Adam J, Huang, Ngan F, Khademhosseini, Ali, Kumar, Sanjay, Li, Song, Wang, Aijun, Wang, Yingxiao   +8 more
core   +2 more sources

Microphysiological systems for human aging research

Aging Cell
AbstractRecent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip (OoC), enable the recapitulation of more complex organ and tissue functions on a smaller scale in vitro. MPS therefore provide the potential to better understand human diseases and physiology.
Seungman Park, Thomas C. Laskow, Jingchun Chen, Prasun Guha, Buddhadeb Dawn, Deok‐Ho Kim   +5 more
openaire   +2 more sources

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Human enteroids: Preclinical models of non-inflammatory diarrhea [PDF]

, 2013
Researchers need an available and easy-to-use model of the human intestine to better understand human intestinal physiology and pathophysiology of diseases, and to offer an enhanced platform for developing drug therapy.
Broughman, J.R. (James), Donowitz, M. (Mark), Estes, M. (Mary), Ettayebi, K. (Khalil), Foulke-Abel, J. (Jennifer), Hyser, J.M. (Joseph), In, J. (Julie), Jonge, H.R. (Hugo) de, Kovbasnjuk, O. (Olga), Middendorp, S., Zachos, N.C. (Nicholas C.), Zeng, X.-L. (Xi-Lei)   +11 more
core   +1 more source

Foreword—Microphysiological Systems

Microphysiological Systems, 2017
It has been increasingly realized that the conventional planar cell cultures do not necessarily reproduce human physiology in vitro due to their limited ability to reproduce the structural and functional complexity of the in vivo counterparts, often resulting in biased outcomes of biological and pharmacological interrogations.
openaire   +1 more source

Developing Micro/Nanostructured Fluidic Mixing Technology for Biomedical Applications

Advanced Science, EarlyView.
This review critically evaluates how micro/nanostructured mixing technologies are redefining biomedical research. By synergizing fundamental analysis, numerical modeling, structural design, and external field manipulation, these systems attain unprecedented control over mass transport.
Junkai Wang, Hanxu Chen, Yile Fang, Yuanjin Zhao   +3 more
wiley   +1 more source

Methods for processing and analyzing images of vascularized micro-organ and tumor systems

Frontiers in Bioengineering and Biotechnology
Our group has developed and validated an advanced microfluidic platform to improve preclinical modeling of healthy and disease states, enabling extended culture and detailed analysis of tissue-engineered miniaturized organ constructs, or “organs-on-chips.
Stephanie J. Hachey, Christopher J. Hatch, Daniela Gaebler, Alexander G. Forsythe, Makena L. Ewald, Alexander L. Chopra, Zhangying Chen, Kapil Thapa, Melvin Hodanu, Jennifer S. Fang, Jennifer S. Fang, Jennifer S. Fang, Christopher C. W. Hughes, Christopher C. W. Hughes, Christopher C. W. Hughes   +14 more
doaj   +1 more source

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine [PDF]

, 2019
A high throughput histology (microTMA) platform was applied for testing drugs against tumors in a novel 3D heterotypic glioblastoma brain sphere (gBS) model consisting of glioblastoma tumor cells, iPSC-derived neurons, glial cells and astrocytes grown in
Ball, Graeme, Hartung, Thomas, Lloyd, Roslyn, Pamies, David, Plummer, Simon, Quiñones-Hinojosa, Alfredo, Schiapparelli, Paula, Wallace, Stephanie   +7 more
core   +4 more sources

Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System

Advanced Electronic Materials, EarlyView.
This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella, Katelyn Neuman, Nolan Burson, Abigail N. Koppes, Ryan A. Koppes   +4 more
wiley   +1 more source