Results 81 to 90 of about 4,549 (220)

Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip

Frontiers in Toxicology
Microphysiological systems (MPS) and Organs-on-Chips (OoCs) hold significant potential for replicating complex human biological processes in vitro. However, their widespread adoption by industry and regulatory bodies depends on effective qualification to
Huub J. Weener, Heleen H. T. Middelkamp, Heleen H. T. Middelkamp, Andries D. Van der Meer   +3 more
doaj   +1 more source

Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system [Elektronisk resurs] [PDF]

Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays.
Gennemark, Peter, Clausen, Maryam, Mullers, Erik,, Leonard, Louise, Kanebratt, Kajsa P.,, Vilen, Liisa K., Rigal, Sophie,, Cairns, Jonathan, Ammala, Carina, Marx, Uwe, Hansson, Sara F.,, Vilen, Liisa K.,, Marx, Uwe,, Lofmark, Rasmus Jansson,, Casas, Belén, Gennemark, Peter,, Magnusson, Lisa U., Rigal, Sophie, Andersson, Tommy B.,, Ammala, Carina,, Leonard, Louise,, Cedersund, Gunnar, Karlsson, Fredrik, Kanebratt, Kajsa P., Andersson, Tommy B., Cairns, Jonathan,, Huldt, Charlotte Wennberg,, Karlsson, Fredrik,, Huldt, Charlotte Wennberg, Lofmark, Rasmus Jansson, Cedersund, Gunnar,, Mullers, Erik, Hansson, Sara F., Casas, Belén,, Magnusson, Lisa U.,, Clausen, Maryam,   +35 more
core   +1 more source

Mechanical stimulation and monitoring of artificial collagen membranes for Organ-on Chip applications

Current Directions in Biomedical Engineering
A novel tool to create artificial, cell-based model systems of biological barriers for preclinical drug testing and basic research are artificial collagen membranes (ACM).
Behrens Stephan, Golde Jonas, Schöps Yvo, Polk Christoph, Seidel Gloria, Goerke Felix, Sonntag Frank, Schmieder Florian   +7 more
doaj   +1 more source

Collagen concentration regulates neutrophil extravasation and migration in response to infection in an endothelium dependent manner

Frontiers in Immunology
IntroductionAs the body’s first line of defense against disease and infection, neutrophils must efficiently navigate to sites of inflammation; however, neutrophil dysregulation contributes to the pathogenesis of numerous diseases that leave people ...
Christopher J. Calo, Tanvi Patil, Mallory Palizzi, Nicola Wheeler, Laurel E. Hind   +4 more
doaj   +1 more source

A Practical Gut‐On‐Chip Workflow for Imaging‐Based Assessment of Epithelial Barrier Dynamics During E. coli Co‐Culture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The intestinal epithelium and its resident microbiota form a dynamic interface that is central to gut homeostasis, but this interface is difficult to model with conventional tools. Static Transwell cultures lack physiological fluid shear, whereas animal models are costly and poorly suited to quantitative, high‐content imaging.
Shih‐Wei Chiang, Chuan‐Yi Yang, Guan‐Yu Chen   +2 more
wiley   +1 more source

Toward clone‐on‐a‐chip: Ethical and legal considerations for organ‐on‐a‐chip evolution

BMEMat, EarlyView.
The term “clone‐on‐a‐chip (CoC)” is introduced as a conceptual warning for personalized organ‐on‐a‐chip platforms and not to suggest technological feasibility, where a CoC ethical discussion extends beyond issues arising from the requirements for informed consent, property rights, commercialization efforts, and cell sourcing to include potentially ...
Muhammed Erkan Karabekmez, Aliakbar Ebrahimi, Hamed Ghorbanpoor, Nicole Bassous, Su Ryon Shin, Yu Shrike Zhang, Huseyin Avci   +6 more
wiley   +1 more source

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications [PDF]

, 2015
Drug discovery and development are hampered by high failure rates attributed to the reliance on non-human animal models employed during safety and efficacy testing.
Huebsch, Nathaniel, Mandegar, Mohammad, Marcus, Sivan G, Conklin, Bruce R, Loskill, Peter, Healy, Kevin E, Shao, Kaifeng, Hong, SoonGweon, Mathur, Anurag, Marks, Natalie, Lee, Luke P   +10 more
core   +1 more source

Exploring the synergy of CRISPR and microphysiological systems

ALTEX
Since its discovery as an innate bacterial immune system, the clustered regularly interspaced short palindromic repeats (CRISPR) associated nuclease 9 (CRISPR-Cas9) system has quickly landed on mammalian genomes to become the first-in-class editing technique.
Emanuele, Celauro, Amer F, Saleh, Prathap K, Mahalingaiah, Lisa, Mohamet, Rhiannon, David, Roberto, Nitsch   +5 more
openaire   +2 more sources

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Oxidative low-density lipoprotein and shear induced calcification within a calcific aortic valve disease-on-a-chip platform

Frontiers in Cardiovascular Medicine
BackgroundEarly-stage calcific aortic valve disease (CAVD) has been characterized by the infiltration of immune cells, reorganization of the extracellular matrix, and the deposition and oxidation of low-density lipoproteins (oxLDL).
Melissa Mendoza-Seale, Mei-Hsiu Chen, Peter Huang, Gretchen J. Mahler   +3 more
doaj   +1 more source