Results 71 to 80 of about 6,388 (235)

Big bottlenecks in cardiovascular tissue engineering. [PDF]

, 2018
Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of ...
Abilez, Oscar J, Huang, Ngan F, Morris, Viola B, Nakayama, Karina H, Pardon, Gaspard, Pruitt, Beth L, Sayed, Nazish, Serpooshan, Vahid, Wu, Joseph C, Wu, Sean M, Yoon, Young-Sup, Zhang, Jianyi   +11 more
core  

Ten Quick Tips for Using a Raspberry Pi

, 2019
Much of biology (and, indeed, all of science) is becoming increasingly computational. We tend to think of this in regards to algorithmic approaches and software tools, as well as increased computing power.
Fletcher, Anthony C, Mura, Cameron
core   +1 more source

Potential value of animal microphysiological systems

ALTEX
Microphysiological systems (MPS) are designed to recapitulate aspects of tissue/organ physiology in vivo, thereby providing potential value in safety and efficacy assessments of FDA-regulated products and regulatory decision-making. While there have been significant advances in the development, use, and proposals of qualification criteria for human ...
Paul C, Brown, Barry H, Hooberman, Brianna L, Skinner, Claudia, Wrzesinski, Dayton M, Petibone, Kevin A, Ford, Kristi L, Muldoon-Jacobs, Kyung E, Sung, Luis G, Valerio, Nakissa N, Sadrieh, Paul C, Howard, Peter L, Goering, Shelby A, Skoog, Suzanne C, Fitzpatrick, Tracy, Chen, Tracy C, MacGill, Donna L, Mendrick   +16 more
openaire   +2 more sources

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model

Frontiers in Bioengineering and Biotechnology
Colonic epithelium is situated above a layer of fibroblasts that provide supportive factors for stem cells at the crypt base and promote differentiation of cells in the upper crypt and luminal surface. To study the fibroblast-epithelial cell interactions,
Angelo Massaro, Cecilia Villegas Novoa, Yuli Wang, Nancy L. Allbritton   +3 more
doaj   +1 more source

A Synthetic Hydrogel, VitroGel® ORGANOID-3, Improves Immune Cell-Epithelial Interactions in a Tissue Chip Co-Culture Model of Human Gastric Organoids and Dendritic Cells

Frontiers in Pharmacology, 2021
Immunosurveillance of the gastrointestinal epithelium by mononuclear phagocytes (MNPs) is essential for maintaining gut health. However, studying the complex interplay between the human gastrointestinal epithelium and MNPs such as dendritic cells (DCs ...
Michelle D. Cherne, Barkan Sidar, T. Andrew Sebrell, Humberto S. Sanchez, Kody Heaton, Francis J. Kassama, Mandi M. Roe, Andrew B. Gentry, Connie B. Chang, Seth T. Walk, Mark Jutila, James N. Wilking, Diane Bimczok   +12 more
doaj   +1 more source

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Improved functionality of hepatic spheroids cultured in acoustic levitation compared to existing 2D and 3D models

Scientific Reports
Hepatic spheroids are of high interest in basic research, drug discovery and cell therapy. Existing methods for spheroid culture present advantages and drawbacks.
Lucile Rabiet, Nathan Jeger-Madiot, Duván Rojas García, Lucie Tosca, Gérard Tachdjian, Sabrina Kellouche, Rémy Agniel, Jérôme Larghero, Jean-Luc Aider, Lousineh Arakelian   +9 more
doaj   +1 more source

Engineering liver organoids-on-a-chip

Frontiers in Lab on a Chip Technologies
Advances in stem cell biology and microengineering have led to the emergence of liver organoids-on-a-chip systems, hybrid platforms that integrate self-organizing three-dimensional organoids with microfluidic devices.
Jiafei Zhu, Anna Dressman, Anna Dressman, Kylee Gall, Sunghee Estelle Park   +4 more
doaj   +1 more source

Microphysiological system for heart tissue - going from 2D to 3D culture

Current Directions in Biomedical Engineering, 2019
Recently, we could demonstrate positive effects of microfluidic cultivation conditions on maturation of cardiomyocytes derived from human induced pluripotent stem cells (iPS-CMs) in a 2D model.
Busek Mathias, Schubert Mario, Guan Kaomei, Sonntag Frank, Schmieder Florian, Marschner Uwe, Richter Andreas   +6 more
doaj   +1 more source