Results 71 to 80 of about 4,549 (220)

Trends in Amyotrophic Lateral Sclerosis Microphysiological Systems and the Challenges [PDF]

한국정밀공학회지
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder marked by the progressive degeneration of motor neurons and muscle atrophy. Despite extensive clinical research, effective treatments remain scarce due to the complexity of the ...
Hee-Gyeong Yi, Sang-Jin Lee, Yeong-Jin Choi, Jin-A Kim   +3 more
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Improved functionality of hepatic spheroids cultured in acoustic levitation compared to existing 2D and 3D models

Scientific Reports
Hepatic spheroids are of high interest in basic research, drug discovery and cell therapy. Existing methods for spheroid culture present advantages and drawbacks.
Lucile Rabiet, Nathan Jeger-Madiot, Duván Rojas García, Lucie Tosca, Gérard Tachdjian, Sabrina Kellouche, Rémy Agniel, Jérôme Larghero, Jean-Luc Aider, Lousineh Arakelian   +9 more
doaj   +1 more source

Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System

Advanced Electronic Materials, EarlyView.
This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella, Katelyn Neuman, Nolan Burson, Abigail N. Koppes, Ryan A. Koppes   +4 more
wiley   +1 more source

Foreword—Microphysiological Systems

Microphysiological Systems, 2017
It has been increasingly realized that the conventional planar cell cultures do not necessarily reproduce human physiology in vitro due to their limited ability to reproduce the structural and functional complexity of the in vivo counterparts, often resulting in biased outcomes of biological and pharmacological interrogations.
openaire   +1 more source

Microphysiological systems for human aging research

Aging Cell
AbstractRecent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip (OoC), enable the recapitulation of more complex organ and tissue functions on a smaller scale in vitro. MPS therefore provide the potential to better understand human diseases and physiology.
Seungman Park, Thomas C. Laskow, Jingchun Chen, Prasun Guha, Buddhadeb Dawn, Deok‐Ho Kim   +5 more
openaire   +2 more sources

Implantation‐On‐Chip: An AI‐Based Platform for Monitoring the Embryo Trophoblast–Endometrial Stroma Cross Talk With Xenobiotics Interference

Advanced Intelligent Systems, EarlyView.
We present a novel AI‐integrated implantation‐on‐chip platform that enables mimicking and monitoring the maternal–fetal interactions at the early phases of human embryo implantation with high spatiotemporal resolution. The complexity of the trophoblast invasion process was addressed by conducting the analysis at global (rate of invasion) and local ...
Joanna Filippi, Valentina Lacconi, Arianna Mencattini, Micol Massimiani, Dolores Lobresca, Gaia Posanzini, Alessia Riccardi, Paola Casti, Michele D’Orazio, Gianni Antonelli, Giorgia Curci, Luisa Campagnolo, Eugenio Martinelli   +12 more
wiley   +1 more source

A microphysiological systems approach to design gastrointestinal system

Journal of Biomaterials Science, Polymer Edition
The gastrointestinal (GI) system is a complex and dynamic organ system, with the anatomy and varied physiological functionality adding complexity to nutrient absorption, immune function, and maintenance of overall health. This review begins with an overview of the anatomy, highlighting key organs and their respective roles, followed by an exploration ...
Vidhi Mathur, Mrunmayi Gadre, Amrutha H. K., Kirthanashri S. Vasanthan   +3 more
openaire   +2 more sources

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

An Immune-Liver Microphysiological System Method for Evaluation of Hepatotoxicity Induced by Polygonum multiflorum Extract [PDF]

Polygonum multiflorum Thunb. (PMT) has occasionally demonstrated adverse effects on liver function in clinical applications. These instances of hepatotoxicity have been linked to PMT samples.
Zhang, X (via Mendeley Data)
core   +1 more source