Results 51 to 60 of about 17,314,856 (225)

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems

, 2017
Liver disease represents a growing global health burden. The development of in vitro liver models which allow the study of disease and the prediction of metabolism and drug-induced liver injury in humans remains a challenge.
David J Hughes, Emma L Sceats, Tomasz Kostrzewski   +2 more
core   +1 more source

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

Advanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo   +3 more
wiley   +1 more source

Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system

, 2021
Kostrzewski et al. introduce an in vitro microphysiological model of non-alcoholic steatohepatitis (NASH), consisting of co-cultured primary human liver cells. The authors characterised the transcriptomic, inflammatory and fibrotic phenotype of the model
Surakala, M., Bornot, A., Battle, A. L., Clausen, M., Corrigan, A., Maass, C., Snow, S., Hughes, D., Ahmad, Z., Ryaboshapkina, M., Kostrzewski, T., Lindgren, J., Lindén, Daniel,, Basak, J., Peel, S., Young, L. M., Ewart, L.   +16 more
core   +1 more source

Adipose Tissue-Derived Stem Cells Retain Their Adipocyte Differentiation Potential in Three-Dimensional Hydrogels and Bioreactors

Biomolecules, 2020
Osteoarthritis (OA) is a common joint disorder with a significant economic and healthcare impact. The knee joint is composed of cartilage and the adjoining bone, a synovial capsule, the infrapatellar fat pad (IPFP), and other connective tissues such as ...
Benjamen T. O'Donnell, Sara Al-Ghadban, Clara J. Ives, Michael P. L'Ecuyer, Tia A. Monjure, Monica Romero-Lopez, Zhong Li, Stuart B. Goodman, Hang Lin, Rocky S. Tuan, Bruce A. Bunnell   +10 more
doaj   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Patient‐Derived Microphysiological Systems for Precision Medicine

Advanced Healthcare Materials, 2023
AbstractPatient‐derived microphysiological systems (P‐MPS) have emerged as powerful tools in precision medicine that provide valuable insight into individual patient characteristics. This review discusses the development of P‐MPS as an integration of patient‐derived samples, including patient‐derived cells, organoids, and induced pluripotent stem cells,
Jihoon Ko, Jiyoung Song, Nakwon Choi, Hong Nam Kim   +3 more
openaire   +2 more sources

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Modelling the innate immune system in microphysiological systems

Lab on a Chip
Integration of an immune component moves the field closer to a physiologically relevant human-on-a-chip.
Michael J. Rupar, Hannah Hanson, Stephanie Rogers, Brianna Botlick, Steven Trimmer, James J. Hickman   +5 more
openaire   +2 more sources

Improved functionality of hepatic spheroids cultured in acoustic levitation compared to existing 2D and 3D models

Scientific Reports
Hepatic spheroids are of high interest in basic research, drug discovery and cell therapy. Existing methods for spheroid culture present advantages and drawbacks.
Lucile Rabiet, Nathan Jeger-Madiot, Duván Rojas García, Lucie Tosca, Gérard Tachdjian, Sabrina Kellouche, Rémy Agniel, Jérôme Larghero, Jean-Luc Aider, Lousineh Arakelian   +9 more
doaj   +1 more source