Results 51 to 60 of about 4,549 (220)
Establishment of a Human iPSC- and Nanofiber-Based Microphysiological Blood–Brain Barrier System [PDF]
, 2018 The blood–brain barrier (BBB) is an active and complex diffusion barrier that separates the circulating blood from the brain and extracellular fluid, regulates nutrient transportation, and provides protection against various toxic compounds and pathogens.
Chi Zhang (9857) +10 more
core +4 more sources
Neodymium‐Doped Nanocrystals for Sensing Cellular Temperature at the Nanoscale
Advanced Optical Materials, EarlyView.Neodymium‐doped NaYF4 nanocrystals are engineered as bright, biocompatible nanothermometers for intracellular temperature mapping. Their ratiometric near‐infrared emission enables highly sensitive, nanoscale thermal readouts in living cells. Combined with gold nanostars for photothermal therapy, they reveal pronounced subcellular heating heterogeneity ...
Maria Bravo +13 more
wiley +1 more source
Patient‐Derived Microphysiological Systems for Precision Medicine
Advanced Healthcare Materials, 2023 AbstractPatient‐derived microphysiological systems (P‐MPS) have emerged as powerful tools in precision medicine that provide valuable insight into individual patient characteristics. This review discusses the development of P‐MPS as an integration of patient‐derived samples, including patient‐derived cells, organoids, and induced pluripotent stem cells,
Jihoon Ko +3 more
openaire +2 more sources
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system [PDF]
, 2023 Atherosclerosis is a primary precursor of cardiovascular disease (CVD), the leading cause of death worldwide. While proprotein convertase subtilisin/kexin 9 (PCSK9) contributes to CVD by degrading low-density lipoprotein receptors (LDLR) and altering ...
Adarsh R. Ettyreddy +12 more
core +1 more source
Human in vitro endometriosis microphysiological system
Current Directions in Biomedical EngineeringEndometriosis is a debilitating condition that causes severe pain and infertility, among other morbidities. It affects 10% of reproductive-aged women worldwide and poses a significant public health challenge due to its prevalence and the lack of ...
Pinheiro Marques Joao +5 more
doaj +1 more source
Biomolecules, 2020 Osteoarthritis (OA) is a common joint disorder with a significant economic and healthcare impact. The knee joint is composed of cartilage and the adjoining bone, a synovial capsule, the infrapatellar fat pad (IPFP), and other connective tissues such as ...
Benjamen T. O'Donnell +10 more
doaj +1 more source
Advanced Science, EarlyView.Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk +9 more
wiley +1 more source
Advances in 3D neuronal microphysiological systems : towards a functional nervous system on a chip [PDF]
, 2021 Microphysiological systems (MPS) designed to study the complexities of the peripheral and central nervous systems have made marked improvements over the years and have allowed researchers to assess in two and three dimensions the functional ...
Bosak, Alexander +4 more
core +1 more source
Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source