Results 91 to 100 of about 4,549 (220)

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Microphysiological Systems: Next Generation Systems for Assessing Toxicity and Therapeutic Effects of Nanomaterials [PDF]

, 2019
Microphysiological systems, also known as organ-on-a-chip platforms, show promise for the development of new testing methods that can be more accurate than both conventional two-dimensional (2D) cultures and costly animal studies. The development of more
Rumeysa Tutar, Hartel, Martin C., Goudie, Marcus J., Nureddin Ashammakhi, Ali Khademhosseini, Lee, Junmin, Darabi, Mohammad Ali, Saber M. Hussein, Khademhosseini, Ali, Junmin Lee, Mercedes Brianna Cornelius, Cornelius, Mercedes Brianna, Hussein, Saber M., Ashammakhi, Nureddin, Çelebi-Saltik, BETÜL, Mehmet R. Dokmeci, Betül Çelebi‐Saltik, Tutar, Rumeysa, Mohammad Ali Darabi, Martin C. Hartel, Dokmeci, Mehmet R., Marcus J. Goudie   +21 more
core   +1 more source

Human Blood‐Brain Tumor Barrier on a Chip to Investigate Personalized Treatment for Glioblastoma Patients

Small, EarlyView.
A microfluidic model of the glioblastoma (GBM) margin was developed to mimic patient‐specific blood‐brain tumor barrier (BBTB) function and drug response. The platform revealed inter‐patient variability in barrier integrity and drug sensitivity, offering a tool for personalized therapy evaluation in GBM.
Minsu Ryoo, Gaeun Lee, Jinwoo Jung, Sujin Cho, Sharon Jeeho Ham, Nayeong Kang, Hyeongjin Ahn, Yu Jin Kim, JeongMin Sim, Jeongman Park, Juwon Kim, Sohyun Hwang, Jihwan Yoo, Youn‐Jung Kang, Jaejoon Lim, Jungho Ahn, Song Ih Ahn   +16 more
wiley   +1 more source

Bioengineering ethics for the age of microphysiological systems

Frontiers in Bioengineering and Biotechnology
The development of microphysiological systems (MPS) is pushing ethical standards in biomedical research to a breaking point. This article argues that only a perspective drawing from engineering ethics will be able to address the new challenges raised by organoids and organs-on-chips.
Maxence Gaillard, Maxence Gaillard
openaire   +3 more sources

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Continuous monitoring of isogenic blood-brain barrier integrity in a pdms-free microphysiological system [PDF]

, 2020
We present a microphysiological system (MPS) of the human blood-brain barrier (BBB) that uniquely combines three key advantages - continuous monitoring, PDMS-free fabrication, and cellular relevance - over existing MPS, and we demonstrate BBB formation ...
Matthiesen, Isabelle,, Winkler, Thomas,, Nikolakopoulou, P., Herland, Anna,, Voulgaris, Dimitrios,   +4 more
core  

Microphysiological systems [PDF]

APL Bioengineering, 2019
James J. Hickman, Dongeun Huh, Roger D. Kamm   +2 more
openaire   +3 more sources

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

VIEW, EarlyView.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder, Kacy Greenhalgh, Joanna Baginska, Camille Martin‐Gallausiaux, Léa Grandmougin, Rémy Villette, Mara Lucchetti, Bérénice Hansen, Marek Ostaszewski, Viacheslav A. Petrov, Koji Atarashi, Lena Weidert, Audrey Frachet Bour, Dominik Ternes, Javier Ramiro‐Garcia, Antoine Malabirade, Takeshi Tanoue, Marc Mac Giolla Eain, Elisabeth Letellier, Matthew Barrett, Jérôme Lacombe, Frederic Zenhausern, Coralie Guérin, Markus Ollert, Carole Seguin‐Devaux, Kenya Honda, Paul Wilmes   +26 more
wiley   +1 more source

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science
Radiation‐induced brain injury (RIBI) is caused by exposure to high doses of ionizing radiation and characterized by severe cognitive dysfunction and brain necrosis. However, the pathogenesis of RIBI is not fully understood, and no effective intervention
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
doaj   +1 more source

Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model

Frontiers in Bioengineering and Biotechnology
Colonic epithelium is situated above a layer of fibroblasts that provide supportive factors for stem cells at the crypt base and promote differentiation of cells in the upper crypt and luminal surface. To study the fibroblast-epithelial cell interactions,
Angelo Massaro, Cecilia Villegas Novoa, Yuli Wang, Nancy L. Allbritton   +3 more
doaj   +1 more source