Results 91 to 100 of about 6,388 (235)

Animal research in the UK: Regulation, implementation, welfare and development of new approach methodologies

Animal Models and Experimental Medicine, EarlyView.
Scientific research with animals in the UK is regulated by the Animals (Scientific Procedures) Act 1986 with the National Centre for the Replacement, Refinement and Reduction of Animals in Research providing support for best practice and facilitating development of new approach methodologies.
Ewan St. John Smith, James Bussell, Maggie Gentry, Elliot Lilley, Cathy Merry, Judy MacArthur Clark, William Reynolds   +6 more
wiley   +1 more source

Interleukin-6 regulates the neutrophil response to diverse bacteria

Frontiers in Immunology
Neutrophils are critical mediators of the innate immune response, and their antimicrobial functions are tightly regulated by a myriad of cytokines. Interleukin-6 (IL-6) is known to be essential for an effective immune response; however, how varying IL-6 ...
Justin M. Owens, Hannah K. Weppner, Aitana Ignes-Romeu, Jacob W. Burleson, Laurel E. Hind   +4 more
doaj   +1 more source

Systems toxicology: real world applications and opportunities [PDF]

, 2017
Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Amin Rostami-Hodjegan, Coecke S., Gary R. Mirams, Hartung T., Imran Shah, Manuel C. Peitsch, Martin F. Wilks, National Institute of Environmental Health Sciences, OECD, Paul Jennings, Rex E. FitzGerald, Shana J. Sturla, Thomas Hartung, van Vliet E., Wilmes A.   +14 more
core   +2 more sources

Exploring the synergy of CRISPR and microphysiological systems

ALTEX
Since its discovery as an innate bacterial immune system, the clustered regularly interspaced short palindromic repeats (CRISPR) associated nuclease 9 (CRISPR-Cas9) system has quickly landed on mammalian genomes to become the first-in-class editing technique.
Emanuele, Celauro, Amer F, Saleh, Prathap K, Mahalingaiah, Lisa, Mohamet, Rhiannon, David, Roberto, Nitsch   +5 more
openaire   +2 more sources

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Designing stem cell niches for differentiation and self-renewal [PDF]

, 2018
Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in
Dalby, Matthew J., Donnelly, Hannah, Salmeron-Sanchez, Manuel   +2 more
core   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Cardiac Meets Skeletal: What's New in Microfluidic Models for Muscle Tissue Engineering [PDF]

, 2016
In the last few years microfluidics and microfabrication technique principles have been extensively exploited for biomedical applications. In this framework, organs-on-a-chip represent promising tools to reproduce key features of functional tissue units ...
Bersini, Simone, Gilardi, Mara, Marsano, Anna, Moretti, Matteo, Rasponi, Marco, Visone, Roberta   +5 more
core   +2 more sources

A Combined Colon Organoid‐Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease

Phytotherapy Research, EarlyView.
Experimental workflow and main findings of the study. ABSTRACT Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity.
Francesco Margiotta, Elena Lucarini, Alessandra Toti, Maria Giovanna Cataldi, Clara Ciampi, Gina Rosalinda De Nicola, Lorenzo Di Cesare Mannelli, Carla Ghelardini   +7 more
wiley   +1 more source

Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment [PDF]

, 2016
Organs-on-chips are three-dimensional, microfluidic cell culture systems that simulate the function of tissues and organ subunits. Organ-on-chip systems are expected to contribute to drug candidate screening and the reduction of animal tests in ...
Hummel, J. Marjan, IJzerman, Maarten J., Meer, Andries D. van der, Middelkamp, Heleen H.T., Mummery, Christine L., Passier, Robert, Stamatialis, Dimitrios F.   +6 more
core   +3 more sources