Results 91 to 100 of about 17,314,856 (225)

Cell‐embedded microgels as emerging miniature 3D tissue‐mimics toward biochip‐based toxicity screening

Bioengineering & Translational Medicine
Recent developments in synthetic three‐dimensional (3D) gel microenvironments for cell culture have enabled the advancement of bioengineered organ‐specific cell niches that resemble the native 3D tissue architecture and mechanics.
Margaux Delafosse, Estelle Regnault, Jasmin Gebauer‐Barrett, Andreas Manz, Baeckkyoung Sung   +4 more
doaj   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model

Frontiers in Bioengineering and Biotechnology
Colonic epithelium is situated above a layer of fibroblasts that provide supportive factors for stem cells at the crypt base and promote differentiation of cells in the upper crypt and luminal surface. To study the fibroblast-epithelial cell interactions,
Angelo Massaro, Cecilia Villegas Novoa, Yuli Wang, Nancy L. Allbritton   +3 more
doaj   +1 more source

Engineering liver organoids-on-a-chip

Frontiers in Lab on a Chip Technologies
Advances in stem cell biology and microengineering have led to the emergence of liver organoids-on-a-chip systems, hybrid platforms that integrate self-organizing three-dimensional organoids with microfluidic devices.
Jiafei Zhu, Anna Dressman, Anna Dressman, Kylee Gall, Sunghee Estelle Park   +4 more
doaj   +1 more source

Paediatric developmental safety and the ICH E11A extrapolation of safety

British Journal of Clinical Pharmacology, EarlyView.
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Rebecca Racz, Sherbet Samuels, Dionna J. Green, Lynne P. Yao   +6 more
wiley   +1 more source

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

VIEW, EarlyView.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder, Kacy Greenhalgh, Joanna Baginska, Camille Martin‐Gallausiaux, Léa Grandmougin, Rémy Villette, Mara Lucchetti, Bérénice Hansen, Marek Ostaszewski, Viacheslav A. Petrov, Koji Atarashi, Lena Weidert, Audrey Frachet Bour, Dominik Ternes, Javier Ramiro‐Garcia, Antoine Malabirade, Takeshi Tanoue, Marc Mac Giolla Eain, Elisabeth Letellier, Matthew Barrett, Jérôme Lacombe, Frederic Zenhausern, Coralie Guérin, Markus Ollert, Carole Seguin‐Devaux, Kenya Honda, Paul Wilmes   +26 more
wiley   +1 more source

Business transformation architecture project : strategic plan

, 2005
Title from p. [1] of PDF document (viewed Oct. 31, 2005).; "MAXIMUS, helping government serve the people"--P.
Ohio Administrative Knowledge System.
core  

The Role of 3D Printing in Organ-on-a-chip Development: Fabrication Strategies and Biomedical Applications [PDF]

한국정밀공학회지
Microphysiological systems (MPS) are advanced platforms that mimic the functions of human tissues and organs, aiding in drug development and disease modeling.
Seonghyuk Park, Jiyoung Song, Noo Li Jeon, Hong Nam Kim   +3 more
doaj   +1 more source

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source

Interleukin-6 regulates the neutrophil response to diverse bacteria

Frontiers in Immunology
Neutrophils are critical mediators of the innate immune response, and their antimicrobial functions are tightly regulated by a myriad of cytokines. Interleukin-6 (IL-6) is known to be essential for an effective immune response; however, how varying IL-6 ...
Justin M. Owens, Hannah K. Weppner, Aitana Ignes-Romeu, Jacob W. Burleson, Laurel E. Hind   +4 more
doaj   +1 more source