Results 111 to 120 of about 4,549 (220)
Interleukin-6 regulates the neutrophil response to diverse bacteria
Frontiers in ImmunologyNeutrophils are critical mediators of the innate immune response, and their antimicrobial functions are tightly regulated by a myriad of cytokines. Interleukin-6 (IL-6) is known to be essential for an effective immune response; however, how varying IL-6 ...
Justin M. Owens +4 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont +3 more
wiley +1 more source
Towards modeling enteric hyperoxaluria in a tripartite microbiota-gut-kidney microphysiological system [PDF]
Hyperoxaluria is a pathological condition characterized by increased levels of oxalate in the urine, which may result in the deposition of oxalate stones, first in the kidneys, with the risk of incurring chronic kidney disease, and, in the most severe ...
Luigina Romani +8 more
core +1 more source
A path forward advancing microphysiological systems
ALTEXMicrophysiological systems (MPS), including organ-on-chip platforms and complex organoid models, represent a transformative approach to human-relevant in vitro modeling. These technol-ogies bioengineer aspects of organ architecture and functionality, revolutionizing drug development, reducing animal testing, and enabling personalized medicine ...
Thomas, Hartung, Lena, Smirnova
openaire +2 more sources
Methods for processing and analyzing images of vascularized micro-organ and tumor systems
Frontiers in Bioengineering and BiotechnologyOur group has developed and validated an advanced microfluidic platform to improve preclinical modeling of healthy and disease states, enabling extended culture and detailed analysis of tissue-engineered miniaturized organ constructs, or “organs-on-chips.
Stephanie J. Hachey +14 more
doaj +1 more source
Journal of Applied Toxicology, Volume 46, Issue 8, Page 2599-2622, August 2026.ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza +2 more
wiley +1 more source
Microphysiological Systems of Lymphatics and Immune Organs
Advanced Healthcare MaterialsAbstract Microphysiological systems (MPS) that incorporate engineered blood vasculatures have enabled new opportunities to study human physiology and disease, offering platforms for drug development, tissue modeling, and regenerative medicine.
Ishita Jain +2 more
openaire +2 more sources
Fluorescent protein biosensors applied to microphysiological systems
Experimental Biology and Medicine, 2015 This mini-review discusses the evolution of fluorescence as a tool to study living cells and tissues in vitro and the present role of fluorescent protein biosensors (FPBs) in microphysiological systems (MPSs). FPBs allow the measurement of temporal and spatial dynamics of targeted cellular events involved in normal and perturbed cellular assay systems ...
Nina, Senutovitch +5 more
openaire +3 more sources
Farewell to Animal Testing: Innovations on Human Intestinal Microphysiological Systems
Micromachines, 2016 The human intestine is a dynamic organ where the complex host-microbe interactions that orchestrate intestinal homeostasis occur. Major contributing factors associated with intestinal health and diseases include metabolically-active gut microbiota ...
Tae Hyun Kang, Hyun Jung Kim
doaj +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, Volume 13, Issue 37, 3 July 2026.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source