Results 111 to 120 of about 6,388 (235)

Evaluating biomaterial-and microfluidic-based 3D tumor models [PDF]

, 2015
Cancer is a major cause of morbidity and mortality worldwide, with a disease burden estimated to increase in the coming decades. Disease heterogeneity and limited information on cancer biology and disease mechanisms are aspects that 2D cell cultures fail
Carvalho, Mariana R., Correlo, V. M., Lima, Daniela, Oliveira, J. M., Reis, R. L.   +4 more
core   +1 more source

A microphysiological systems approach to design gastrointestinal system

Journal of Biomaterials Science, Polymer Edition
The gastrointestinal (GI) system is a complex and dynamic organ system, with the anatomy and varied physiological functionality adding complexity to nutrient absorption, immune function, and maintenance of overall health. This review begins with an overview of the anatomy, highlighting key organs and their respective roles, followed by an exploration ...
Vidhi Mathur, Mrunmayi Gadre, Amrutha H. K., Kirthanashri S. Vasanthan   +3 more
openaire   +2 more sources

The use of microphysiological systems to model metastatic cancer [PDF]

Biofabrication
Abstract Cancer is one of the leading causes of death in the 21st century, with metastasis of cancer attributing to 90% of cancer-related deaths. Therefore, to improve patient outcomes there is a need for better preclinical models to increase the success of translating oncological therapies into the clinic.
Caitlin E Jackson, Nicola H Green, William R English, Frederik Claeyssens   +3 more
openaire   +4 more sources

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, EarlyView.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source

Mechanical stimulation and monitoring of artificial collagen membranes for Organ-on Chip applications

Current Directions in Biomedical Engineering
A novel tool to create artificial, cell-based model systems of biological barriers for preclinical drug testing and basic research are artificial collagen membranes (ACM).
Behrens Stephan, Golde Jonas, Schöps Yvo, Polk Christoph, Seidel Gloria, Goerke Felix, Sonntag Frank, Schmieder Florian   +7 more
doaj   +1 more source

Collagen concentration regulates neutrophil extravasation and migration in response to infection in an endothelium dependent manner

Frontiers in Immunology
IntroductionAs the body’s first line of defense against disease and infection, neutrophils must efficiently navigate to sites of inflammation; however, neutrophil dysregulation contributes to the pathogenesis of numerous diseases that leave people ...
Christopher J. Calo, Tanvi Patil, Mallory Palizzi, Nicola Wheeler, Laurel E. Hind   +4 more
doaj   +1 more source

Metabolic origins of spatial organization in the tumor microenvironment. [PDF]

, 2017
The genetic and phenotypic diversity of cells within tumors is a major obstacle for cancer treatment. Because of the stochastic nature of genetic alterations, this intratumoral heterogeneity is often viewed as chaotic.
Akkari, L., Carmona-Fontaine, C., Deforet, M., Joyce, J.A., Thompson, C.B., Xavier, J.B.   +5 more
core   +2 more sources

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source

DB-ALM Report, 2016 [PDF]

, 2016
This deliverable report outlines the activities performed during January 2014-June 2016 for the DB-ALM (EURL ECVAM DataBase service on advanced and Alternative Methods) enhancements regarding: information content, system evolution and innovation, as well
COE ANTHONY, FLEGO Manuela, JANUSCH ROI Annett, SWIATEK AGNIESZKA LIDIA   +3 more
core   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source