Results 111 to 120 of about 17,314,856 (225)
Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi +10 more
wiley +1 more source
A path forward advancing microphysiological systems
ALTEXMicrophysiological systems (MPS), including organ-on-chip platforms and complex organoid models, represent a transformative approach to human-relevant in vitro modeling. These technol-ogies bioengineer aspects of organ architecture and functionality, revolutionizing drug development, reducing animal testing, and enabling personalized medicine ...
Thomas, Hartung, Lena, Smirnova
openaire +2 more sources
Advanced Materials Technologies, Volume 11, Issue 19, 7 October 2026.A collagen‐based gut‐on‐chip model replicates the intestinal extracellular matrix, supporting villi‐like structures, tight junctions, and mucin production. This biomimetic platform enables rapid epithelial differentiation and functional barrier formation.
Fernanda López García +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 55, 5 October 2026.Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang +9 more
wiley +1 more source
NEW MICROPHYSIOLOGICAL BONE MARROW MODEL SYSTEM, ALLOWING LONG-TERM PLASMA CELLS SURVIVAL, SUITABLE FOR IMMUNE DRUG TESTING New microphysiological bone marrow model system, allowing long-term plasma cells survival, suitable for immune drug testing ...
Martini, Stefania
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Vascularized joint‐on‐a‐chip: A paradigm shift for arthritis pathophysiology and clinical treatment
Rheumatology &Autoimmunity, EarlyView.
Danli Cui +6 more
wiley +1 more source
Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.Intermittent catheter use can damage the urinary tract and predispose to infection. We deployed a complex human urothelial model to investigate. Catheter contact induced compressive and shear stress causing umbrella cell disruption, reduced barrier function, inflammation and increased cell adhesion to the catheter surface.
Nazila V. Jafari, Jennifer L. Rohn
wiley +1 more source
Scalable microphysiological system to model three-dimensional blood vessels
APL Bioengineering, 2019 Blood vessel models are increasingly recognized to have value in understanding disease and drug discovery. However, continued improvements are required to more accurately reflect human vessel physiology. Realistic three-dimensional (3D) in vitro cultures
Mees N. S. de Graaf +7 more
doaj +1 more source
Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles
Developmental Neurobiology, Volume 86, Issue 4, October 2026.ABSTRACT Organoids are self‐organized, in vitro 3D structures derived from progenitor or pluripotent stem cells. During culture, these tissues secrete small extracellular vesicles (sEVs)—functional bioactive molecules—into their microenvironment. Here, we differentiated iPSC‐derived cerebral organoids (COs) under three culture conditions (static ...
Elifsu Polatlı +6 more
wiley +1 more source
State of Ohio : strategic plan
, 2005 Title from URL of PDF document (viewed Nov. 1, 2005).; "6/20/2005"--P. 1, etc.; Harvested from the web on 11/1/055.3.1.00 general ledger (135 p.) -- 5.3.2.00 accounts payable (77 p.) -- 5.3.3.00 procurement (180 p.) -- 5.3.4.00 grants, project costing ...
Ohio Administrative Knowledge System.
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