Results 131 to 140 of about 4,549 (220)

Engineering Challenges in Microphysiological Systems [PDF]

Future Science OA, 2017
openaire   +2 more sources

Neutrophil Macrophage Crosstalk via Extracellular Vesicles Drives Reverse Migration in a Fully Human Model of Wound Healing

Advanced Science
Persistent neutrophilic inflammation can lead to tissue damage and chronic inflammation, contributing to non‐healing wounds. The resolution phase of neutrophilic inflammation is critical to preventing tissue damage.
Kehinde Adebayo Babatunde, Oluwadamilola Fatimat Babatunde, Adeel Ahmed, Wilmara Salgado‐Pabon, David J Beebe, Sheena C. Kerr   +5 more
doaj   +1 more source

Development of a Novel Microphysiological System for Peripheral Neurotoxicity Prediction Using Human iPSC-Derived Neurons with Morphological Deep Learning

Toxics
A microphysiological system (MPS) is an in vitro culture technology that reproduces the physiological microenvironment and functionality of humans and is expected to be applied for drug screening.
Xiaobo Han, Naoki Matsuda, Makoto Yamanaka, Ikuro Suzuki   +3 more
doaj   +1 more source

Ultrastructural Study of Microphysiological Systems of the Tumor Microenvironment

Small Science
The importance of studying the ultrastructure is underwritten by decades of research. Ultrastructural features help to understand pathological processes or inform disease diagnosis. However, ultrastructural studies in the promising cancer‐on‐a‐chip models are practically nonexistent because of the complexity of sample preparation for electron ...
Paula Guerrero‐López, Karinna Georgiana Pele, Mariano Barrado, Pilar Alamán‐Díez, José Manuel García‐Aznar, Elena García‐Gareta   +5 more
openaire   +2 more sources

Organ-on-a-Chip Models—New Possibilities in Experimental Science and Disease Modeling

Biomolecules
‘Organ-on-a-chip’ technology is a promising and rapidly evolving model in biological research. This innovative microfluidic cell culture device was created using a microchip with continuously perfused chambers, populated by living cells arranged to ...
Bartłomiej Wysoczański, Marcin Świątek, Anna Wójcik-Gładysz   +2 more
doaj   +1 more source

Modelling cardiovascular diseases using human microphysiological systems [PDF]

Despite pharmacological-, technological- and medical- advances, cardiovascular diseases (CVDs) remain the main cause of death and disability in the world.
Inácio, José Manuel, Vital, Carlos Miguel, Rybak-Wolf, Agnieszka, Marques, André R.A., Belo, José António, Lopes, Elizeth, Ferreira, Inês S., Guerreiro Simões, Catarina, Ribeiro, Quélia Ribeiro, Vieira, Otília V.   +9 more
core   +1 more source

Engineering a microphysiological model for regenerative endodontic studies [PDF]

Dental pulp infections are common buccal diseases. When this happens, endodontic treatments are needed to disinfect and prepare the root canal for subsequent procedures.
Diana Sanz-Serrano, Sanz-Serrano, Diana, Mercadé Bellido, Montserrat, Francesc Ventura, Ventura Pujol, Francesc, Sánchez de Diego, Cristina, Cristina Sánchez-de-Diego, Montse Mercade   +7 more
core   +1 more source

Development of a kidney microphysiological system hardware platform for microgravity studies

npj Microgravity
Determining the physiological effects of microgravity on the human kidney is limited to relatively insensitive tests of biofluids (blood and urine) that do not return abnormal results until more than 50% of kidney function is lost.
Kendan A. Jones-Isaac, Kevin A. Lidberg, Catherine K. Yeung, Jade Yang, Jacelyn Bain, Micaela Ruiz, Greta Koenig, Paul Koenig, Stefanie Countryman, Jonathan Himmelfarb, Edward J. Kelly   +10 more
doaj   +1 more source

De novo establishment of an ex vivo culture for living myocardial slices applying a microphysiological system – MPSlms

Current Directions in Biomedical Engineering
Cardiovascular disease is a global health burden. To develop novel treatment options complex in vitro model systems are needed that resemble the pathophysiological situation ex vivo.
Jordan Maria, Schmieder Florian, Waleczek Florian J. G., Polk Christoph, Stucki-Koch Angelika, Philipp Jürgen, Dietzel Leila, Clement Alexander, Behrens Stephan, Thum Thomas, Sonntag Frank, Fiedler Jan   +11 more
doaj   +1 more source

Effects of Sevoflurane on the Development of a Human Brain Microphysiological System. [PDF]

Int J Mol Sci
Li Q, Ding L, Morales Pantoja IE, Modiri N, Smirnova L, Mintz CD.   +5 more
europepmc   +1 more source