Results 121 to 130 of about 17,314,856 (225)

Organoids: Current Applications and Future Directions

MedComm, Volume 7, Issue 10, October 2026.
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng, Yue Wang, Canhui Cao, Feng Deng, Weisi Lian, Xingtong Chen, Mingmei Lin, Zhonghong Zeng, Dan Mo, Shangqi Li, Yilei He, Yang Yu, Heng Pan, Ping Zhou, Rong Li   +14 more
wiley   +1 more source

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, Volume 81, Issue 10, Page 3488-3503, October 2026.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source

Facile photopatterning of perfusable microchannels in hydrogels for microphysiological systems

Perfusable hydrogels have garnered substantial attention in recent years for the fabrication of microphysiological systems. However, current methodologies to fabricate microchannels in hydrogel platforms involve sophisticated equipment and techniques ...
Garc\ueda, Andr\ue9s J., Mora-Boza, Ana, Singh, Ankur, Burdick, Jason A., Mulero-Russe, Adriana, Di Caprio, Nikolas, O\u2019Neill, Eric   +6 more
core   +1 more source

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, Volume 604, Issue 19, Page 8069-8099, 1 October 2026.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source

Comprehensive annual financial report for the year ended ... (Online); Comprehensive annual financial report

, 2003
Annual; Dec. 31, 2002-; Description based on: 2002; title from PDF cover (viewed on Jan.
Ohio Public Employees Retirement System.
core  

A multi-organ microphysiological system for radiopharmaceutical biodistribution studies

Current Directions in Biomedical Engineering
Radiopharmaceuticals play a crucial role in positron emission tomography for diagnostic imaging and targeted cancer therapy. Their biodistribution and metabolism must be thoroughly characterized during preclinical development.
Petzold Mandy, Sihver Wiebke, Dzekhtsiarova Yuliya, Nitt-Weber Anne-Kathrin, Behrens Stephan, Maxová Hedvika, Schmieder Florian   +6 more
doaj   +1 more source

Evaluation of Perfusion Cell Culture Conditions in a Double-Layered Microphysiological System Using AI-Assisted Morphological Analysis

Micromachines
In recent years, microphysiological systems (MPS) using microfluidic technology as a new in vitro experimental system have shown promise as an alternative to animal experiments in the development of drugs, especially in the field of drug discovery, and ...
Naokata Kutsuzawa, Tomomi Goto, Hiroko Nakamura, Miwa Maeda, Masaki Kinehara, Junko Sakagami, Hiroshi Kimura   +6 more
doaj   +1 more source

Perspective of using in vitro models to understand immunotherapy-induced cytokine release syndrome

Frontiers in Immunology
Since the TGN1412 clinical trial failure to predict cytokine release syndrome (CRS) during preclinical trials, alternative in vitro models have become increasingly important for identifying potential adverse outcomes in early drug development ...
Ethan Perkins, Ethan Perkins, Christopher Cooper, Emma Lund, Miriam Alb, Hannah Morgan, Birgit Fogal, Philip Hewitt, Alexander Mazein, Marek Ostaszewski, Katherina Sewald   +10 more
doaj   +1 more source

An Immune-Liver Microphysiological System Method for Evaluation of Hepatotoxicity Induced by Polygonum multiflorum Extract

Polygonum multiflorum Thunb. (PMT) has occasionally demonstrated adverse effects on liver function in clinical applications. These instances of hepatotoxicity have been linked to PMT samples.
Zhang, X (via Mendeley Data)
core   +1 more source

A Microphysiological System with an Anaerobic Air‐Liquid Interface and Functional Mucus Layer for Coculture of Intestinal Bacteria and Primary Human Colonic Epithelium

Advanced Materials Interfaces
Coculture of intestinal bacteria with primary human intestinal epithelium provides a valuable tool for investigating host‐colon bacterial interactions and for testing and screening therapeutics.
Raehyun Kim, Nancy L. Allbritton
doaj   +1 more source