Results 121 to 130 of about 4,549 (220)

Scalable microphysiological system to model three-dimensional blood vessels

APL Bioengineering, 2019
Blood vessel models are increasingly recognized to have value in understanding disease and drug discovery. However, continued improvements are required to more accurately reflect human vessel physiology. Realistic three-dimensional (3D) in vitro cultures
Mees N. S. de Graaf, Amy Cochrane, Francijna E. van den Hil, Wesley Buijsman, Andries D. van der Meer, Albert van den Berg, Christine L. Mummery, Valeria V. Orlova   +7 more
doaj   +1 more source

Organ Chips and Translational Research: Identifying and Examining New Ethical Issues

Ethics &Human Research, Volume 48, Issue 4, Page 39-45, July–August 2026.
ABSTRACT Organ chips, also known as organ‐on‐a‐chip devices, tissue chips, or microphysiological systems, have emerged over the last decade as a promising translational technology amidst growing concern about the translational crisis between laboratory research and patient bedside.
Melanie Jeske
wiley   +1 more source

Microphysiological modeling of the reproductive tract: A fertile endeavor [PDF]

, 2014
Preclinical toxicity testing in animal models is a cornerstone of the drug development process, yet it is often unable to predict adverse effects and tolerability issues in human subjects.
Kim, J. Julie, Burdette, Joanna E., Eddie, Sharon L., Woodruff, Teresa K.   +3 more
core   +1 more source

In vitro models of the gut-liver axis: what we’ve learned and what remains to be built

Frontiers in Immunology
The gut-liver axis maintains metabolic homeostasis and immune regulation through continuous bidirectional communication, and its dysregulation contributes to a range of metabolic, inflammatory, and immune-mediated diseases.
Jong Hwan Sung, Raehyun Kim
doaj   +1 more source

Engineered Red Blood Cell‐Derived Extracellular Vesicles With Klotho Peptide Protect the Kidney From Fibrosis

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
In this study, we engineered red blood cell–derived extracellular vesicles with a Klotho‐derived peptide (RBC‐EVKP1) to target kidney fibrosis. Engineered RBC‐EVKP1, through inhibition of TGF‐β2/TGFβ receptor binding, and downstream signaling, reduced fibrotic and mesenchymal marker expression and extracellular matrix accumulation in proximal tubular ...
Tunahan Ergunay, Alessia Brossa, Michela Arena, Stefania Bruno, Alessandro Gori, Anne Metje van Genderen, Rosalinde Masereeuw, Benedetta Bussolati   +7 more
wiley   +1 more source

An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii [PDF]

Crosstalk of microbes with human gut epithelia and immune cells is crucial for gut health. However, there is no existing system for a long-term co-culture of human innate immune cells with epithelium and oxygen-intolerant commensal microbes, hindering ...
Wright, Charles, Trapecar, Martin, Griffith, L.G., Alm, Eric J., Schneider, K., Poyet, Mathilde, Trumper, D.L., Breault, David T., Hernandez-Gordillo, Victor, Yoon, J.Y., Zhang, J.; id_orcid, Huang, Y.-J., Zhang, Jianbo, Kemmitt, John, Breault, D.T., Schneider, Kirsten, Kemmitt, J., Trapecar, M., Poyet, M., Yoon, Jun Young, Trumper, David L., Griffith, Linda G., Hernandez-Gordillo, V., Huang, Yu-Ja, Alm, E.J., Wright, C.   +25 more
core   +1 more source

A Microphysiological System with an Anaerobic Air‐Liquid Interface and Functional Mucus Layer for Coculture of Intestinal Bacteria and Primary Human Colonic Epithelium

Advanced Materials Interfaces
Coculture of intestinal bacteria with primary human intestinal epithelium provides a valuable tool for investigating host‐colon bacterial interactions and for testing and screening therapeutics.
Raehyun Kim, Nancy L. Allbritton
doaj   +1 more source

Perspective of using in vitro models to understand immunotherapy-induced cytokine release syndrome

Frontiers in Immunology
Since the TGN1412 clinical trial failure to predict cytokine release syndrome (CRS) during preclinical trials, alternative in vitro models have become increasingly important for identifying potential adverse outcomes in early drug development ...
Ethan Perkins, Ethan Perkins, Christopher Cooper, Emma Lund, Miriam Alb, Hannah Morgan, Birgit Fogal, Philip Hewitt, Alexander Mazein, Marek Ostaszewski, Katherina Sewald   +10 more
doaj   +1 more source

Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure [PDF]

Transition to extrauterine life results in a surge of catecholamines necessary for increased cardiovascular, respiratory, and metabolic activity. Mechanisms mediating adrenomedullary catecholamine release are poorly understood.
Abigail N. Koppes (4975532), Jonathan R. Soucy (7256546), Ryan A. Koppes (4975535), Kyla Nichols (18320544), Ryan Brady (2542129), Gabriel Burchett (18320542), David T. Breault (5039903)   +6 more
core   +1 more source

Development of Microphysiological Models for the Assessment of Xenobiotic and Endobiotic Absorption and Disposition [PDF]

, 2018
Thesis (Ph.D.)--University of Washington, 2018Animal models and in vitro systems have long been relied upon to provide insights into the toxicology, pharmacodynamics and pharmacokinetics of investigational drug candidates before they are administered to ...
Chapron, Brian
core