Results 101 to 110 of about 6,388 (235)

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations [PDF]

, 2018
A smart sensor system for cell culture real-time supervision is proposed, allowing for a significant reduction in human effort applied to this type of assay. The approach converts the cell culture under test into a suitable “biological” oscillator.
Daza Navarro, María Paula, Huertas Sánchez, Gloria, Maldonado-Jacobi, Andrés, Martín Rubio, María Esther, Olmo Fernández, Alberto, Pérez García, Pablo, Rueda Rueda, Adoración (Coordinador), Serrano Viseas, Juan Alfonso, Sánchez Aguayo, Inmaculada (Coordinador), Yúfera García, Alberto   +9 more
core  

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, lethal malignancy that invades adjacent vasculatures and spreads to distant sites before clinical detection.
Alimperti, Styliani, Chen, Christopher S., Eyckmans, Jeroen, Lee, Esak, Lee, Jake June-Koo, Nguyen, Duc-Huy T., Norgard, Robert J., Stanger, Ben Z., Wong, Alec   +8 more
core   +1 more source

Bioengineering ethics for the age of microphysiological systems

Frontiers in Bioengineering and Biotechnology
The development of microphysiological systems (MPS) is pushing ethical standards in biomedical research to a breaking point. This article argues that only a perspective drawing from engineering ethics will be able to address the new challenges raised by organoids and organs-on-chips.
Maxence Gaillard, Maxence Gaillard
openaire   +3 more sources

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

VIEW, EarlyView.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder, Kacy Greenhalgh, Joanna Baginska, Camille Martin‐Gallausiaux, Léa Grandmougin, Rémy Villette, Mara Lucchetti, Bérénice Hansen, Marek Ostaszewski, Viacheslav A. Petrov, Koji Atarashi, Lena Weidert, Audrey Frachet Bour, Dominik Ternes, Javier Ramiro‐Garcia, Antoine Malabirade, Takeshi Tanoue, Marc Mac Giolla Eain, Elisabeth Letellier, Matthew Barrett, Jérôme Lacombe, Frederic Zenhausern, Coralie Guérin, Markus Ollert, Carole Seguin‐Devaux, Kenya Honda, Paul Wilmes   +26 more
wiley   +1 more source

Microphysiological systems [PDF]

APL Bioengineering, 2019
James J. Hickman, Dongeun Huh, Roger D. Kamm   +2 more
openaire   +3 more sources

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip

Frontiers in Toxicology
Microphysiological systems (MPS) and Organs-on-Chips (OoCs) hold significant potential for replicating complex human biological processes in vitro. However, their widespread adoption by industry and regulatory bodies depends on effective qualification to
Huub J. Weener, Heleen H. T. Middelkamp, Heleen H. T. Middelkamp, Andries D. Van der Meer   +3 more
doaj   +1 more source

The Role of 3D Printing in Organ-on-a-chip Development: Fabrication Strategies and Biomedical Applications [PDF]

한국정밀공학회지
Microphysiological systems (MPS) are advanced platforms that mimic the functions of human tissues and organs, aiding in drug development and disease modeling.
Seonghyuk Park, Jiyoung Song, Noo Li Jeon, Hong Nam Kim   +3 more
doaj   +1 more source

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload. [PDF]

, 2018
The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies.
Boggess, Steven, Conklin, Bruce R, Grigoropoulos, Costas P, Healy, Kevin E, Huebsch, Nathaniel, Koo, Sangmo, Ma, Zhen, Mandegar, Mohammad A, Siemons, Brian   +8 more
core   +1 more source