Results 101 to 110 of about 4,549 (220)
Allergy, EarlyView.Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert +9 more
wiley +1 more source
Engineering liver organoids-on-a-chip
Frontiers in Lab on a Chip TechnologiesAdvances in stem cell biology and microengineering have led to the emergence of liver organoids-on-a-chip systems, hybrid platforms that integrate self-organizing three-dimensional organoids with microfluidic devices.
Jiafei Zhu +4 more
doaj +1 more source
The Role of 3D Printing in Organ-on-a-chip Development: Fabrication Strategies and Biomedical Applications [PDF]
한국정밀공학회지Microphysiological systems (MPS) are advanced platforms that mimic the functions of human tissues and organs, aiding in drug development and disease modeling.
Seonghyuk Park +3 more
doaj +1 more source
Cancer Science, EarlyView.An interstitial lung disease model for DXd antibody‐drug conjugates was established in cynomolgus monkeys by weekly dosing of a non‐targeting DXd ADC. Integrated analysis of bronchoalveolar lavage fluid–derived extracellular vesicle proteomics and lung single‐cell RNA sequencing reveals cell‐type‐resolved molecular features of DXd ADC‐related lung ...
Kazuyoshi Kumagai +5 more
wiley +1 more source
Bioengineering & Translational MedicineRecent developments in synthetic three‐dimensional (3D) gel microenvironments for cell culture have enabled the advancement of bioengineered organ‐specific cell niches that resemble the native 3D tissue architecture and mechanics.
Margaux Delafosse +4 more
doaj +1 more source
Paediatric developmental safety and the ICH E11A extrapolation of safety
British Journal of Clinical Pharmacology, EarlyView.
Gilbert J. Burckart +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger +4 more
wiley +1 more source
A Poly-L-Lactide scaffold with continuous gradient pore size for osteochondral regeneration validated in a microphysiological tissue system bioreactor [PDF]
, 2016 A microphysiological tissue system (MPS) bioreactor has been developed to replicate in vitro the in vivo OC physiological conditions. The MPS allows separate control of the chondral and osseous environment while permitting communication between ...
LA CARRUBBA, Vincenzo +6 more
core
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida +7 more
wiley +1 more source
The use of microphysiological systems to model metastatic cancer [PDF]
BiofabricationAbstract Cancer is one of the leading causes of death in the 21st century, with metastasis of cancer attributing to 90% of cancer-related deaths. Therefore, to improve patient outcomes there is a need for better preclinical models to increase the success of translating oncological therapies into the clinic.
Caitlin E Jackson +3 more
openaire +4 more sources