Results 101 to 110 of about 17,314,856 (225)

Virtual cell construction for artificial intelligence‐driven drug discovery

British Journal of Pharmacology, EarlyView.
Cells are the fundamental units through which genetic variation and pharmacological perturbations influence disease processes and therapeutic responses. However, cellular responses to intervention are strongly shaped by biological context, creating a central challenge for drug discovery: predicting how specific perturbations reshape cellular systems ...
Yuran Jia, Xiao Xing, Haoyang Han, Yuansong Zhao, Shiyao Zhou, Jingjing Chen   +5 more
wiley   +1 more source

Bioengineering ethics for the age of microphysiological systems

Frontiers in Bioengineering and Biotechnology
The development of microphysiological systems (MPS) is pushing ethical standards in biomedical research to a breaking point. This article argues that only a perspective drawing from engineering ethics will be able to address the new challenges raised by organoids and organs-on-chips.
Maxence Gaillard, Maxence Gaillard
openaire   +3 more sources

Fluorescent protein biosensors applied to microphysiological systems

Experimental Biology and Medicine, 2015
This mini-review discusses the evolution of fluorescence as a tool to study living cells and tissues in vitro and the present role of fluorescent protein biosensors (FPBs) in microphysiological systems (MPSs). FPBs allow the measurement of temporal and spatial dynamics of targeted cellular events involved in normal and perturbed cellular assay systems ...
Nina, Senutovitch, Lawrence, Vernetti, Robert, Boltz, Richard, DeBiasio, Albert, Gough, D Lansing, Taylor   +5 more
openaire   +3 more sources

Integrating an aerosolised drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system

Dataset to support publication: Integrating an aerosolised drug delivery device with conventional static cultures and a dynamic airway barrier microphysiological system.
Swindle, Emily, Fernandes, Joao, Cabaco, Morgan, Hywel, Karra, Nikita   +3 more
core   +1 more source

In vitro models of the gut-liver axis: what we’ve learned and what remains to be built

Frontiers in Immunology
The gut-liver axis maintains metabolic homeostasis and immune regulation through continuous bidirectional communication, and its dysregulation contributes to a range of metabolic, inflammatory, and immune-mediated diseases.
Jong Hwan Sung, Raehyun Kim
doaj   +1 more source

Decoding host–microbial dynamics in peri‐implantitis: Ecosystem‐specific experimental models

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is an inflammatory disease arising within a unique host–microbial–biomaterial ecosystem. Unlike periodontitis, peri‐implant tissues lack a periodontal ligament and epithelial junction integrity and interface with metal oxides on titanium surfaces.
Georgios A. Kotsakis, Davi Araújo, Asaf Wilensky, Juliana Girón Bastidas, Stella Alimperti, Flavia Pirih   +5 more
wiley   +1 more source

Human placental transfer of xenobiotics in health and disease: New approach methodologies for developmental and reproductive toxicology testing and mathematical modelling

The Journal of Physiology, EarlyView.
Abstract figure legend New approach methodologies (NAMs) to test the pharmaco‐ and chemicokinetics of compound transfer across the human placental barrier in late pregnancy. Abstract This review addresses an important and timely topic at the intersection of placental biology with respect to barrier transfer kinetics, toxicology and mathematical ...
Paul Brownbill, Eleanor Doman
wiley   +1 more source

Methods for processing and analyzing images of vascularized micro-organ and tumor systems

Frontiers in Bioengineering and Biotechnology
Our group has developed and validated an advanced microfluidic platform to improve preclinical modeling of healthy and disease states, enabling extended culture and detailed analysis of tissue-engineered miniaturized organ constructs, or “organs-on-chips.
Stephanie J. Hachey, Christopher J. Hatch, Daniela Gaebler, Alexander G. Forsythe, Makena L. Ewald, Alexander L. Chopra, Zhangying Chen, Kapil Thapa, Melvin Hodanu, Jennifer S. Fang, Jennifer S. Fang, Jennifer S. Fang, Christopher C. W. Hughes, Christopher C. W. Hughes, Christopher C. W. Hughes   +14 more
doaj   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials
Abstract Microphysiological systems (MPS) that incorporate engineered blood vasculatures have enabled new opportunities to study human physiology and disease, offering platforms for drug development, tissue modeling, and regenerative medicine.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
openaire   +2 more sources