Results 21 to 30 of about 17,314,856 (225)
Gravity-Based Flow Efficient Perfusion Culture System for Spheroids Mimicking Liver Inflammation
Biomedicines, 2021 The spheroid culture system provides an efficient method to emulate organ-specific pathophysiology, overcoming the traditional two-dimensional (2D) cell culture limitations.
Young-Su Kim +5 more
doaj +1 more source
Microphysiological Systems to Assess Nonclinical Toxicity [PDF]
Current Protocols in Toxicology, 2017 AbstractThe liver and the kidney are key toxicity target organs during drug development campaigns, as they typically carry the burden of drug transport and metabolism. Primary hepatocytes and proximal tubule epithelial cells grown in traditional in vitro 2‐D culture systems do not maintain transporter and metabolic functions, thus limiting their ...
Kirk P, Van Ness +5 more
openaire +2 more sources
A microphysiological system model of therapy for liver micrometastases [PDF]
, 2014 Metastasis accounts for almost 90% of cancer-associated mortality. The effectiveness of cancer therapeutics is limited by the protective microenvironment of the metastatic niche and consequently these disseminated tumors remain incurable.
Borenstein, Jeffrey T. +12 more
core +1 more source
Frontiers in Immunology, 2021 Existing first-line cancer therapies often fail to cope with the heterogeneity and complexity of cancers, so that new therapeutic approaches are urgently needed.
Oanh T. P. Nguyen +6 more
doaj +1 more source
Stem cell-based vascularization of microphysiological systems [PDF]
Stem Cell Reports, 2021 Microphysiological systems (MPSs) (i.e., tissue or organ chips) exploit microfluidics and 3D cell culture to mimic tissue and organ-level physiology. The advent of human induced pluripotent stem cell (hiPSC) technology has accelerated the use of MPSs to study human disease in a range of organ systems. However, in the reduction of system complexity, the
Browne, Shane +4 more
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Microphysiologic systems in female reproductive biology [PDF]
Experimental Biology and Medicine, 2017 Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a ...
Alexandria N, Young +3 more
openaire +2 more sources
Organoids pharmacology and toxicology
EngMedicineModel evolution is crucial for understanding the effects and safety of drugs in pharmacological and toxicological research. Traditional cell lines and animal models have contributed significantly to drug development.
Jie Sun +7 more
doaj +1 more source
Recent Advances in the Gastrointestinal Complex in Vitro Model for ADME Studies
Pharmaceutics, 2023 Intestinal absorption is a complex process involving the permeability of the epithelial barrier, efflux transporter activity, and intestinal metabolism.
Kazuyoshi Michiba +3 more
doaj +1 more source
Development of a functional sarcopenia model utilizing a microcantilever microphysiological system as a phenotypic disease model. [PDF]
In Vitro ModelPURPOSE: Sarcopenia is a skeletal muscle (SKM) condition marked by reduced muscle mass and function and is often observed as a comorbidity with inflammatory conditions. METHODS: We have developed a defined in vitro functional model to study sarcopenia by
Jangir H +3 more
europepmc +2 more sources
Microphysiological Systems: Design, Fabrication, and Applications
ACS Biomaterials Science & Engineering, 2020 Microphysiological systems, including organoids, 3-D printed tissue constructs and organ-on-a-chips (organ chips), are physiologically relevant in vitro models and have experienced explosive growth in the past decades. Different from conventional, tissue culture plastic-based in vitro models or animal models, microphysiological systems recapitulate key
Kai Wang +6 more
openaire +3 more sources