Recent Advances in the Gastrointestinal Complex in Vitro Model for ADME Studies
Pharmaceutics, 2023 Intestinal absorption is a complex process involving the permeability of the epithelial barrier, efflux transporter activity, and intestinal metabolism.
Kazuyoshi Michiba +3 more
doaj +1 more source
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]
, 2013 Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D +6 more
core +2 more sources
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies [PDF]
, 2018 Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion.
Brij M. Bhushan +37 more
core +2 more sources
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies [PDF]
, 2017 Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development, and therefore several in vitro systems are routinely employed for this purpose.
Chen, Wen Li +5 more
core +2 more sources
Microphysiological Systems to Assess Nonclinical Toxicity [PDF]
Current Protocols in Toxicology, 2017 AbstractThe liver and the kidney are key toxicity target organs during drug development campaigns, as they typically carry the burden of drug transport and metabolism. Primary hepatocytes and proximal tubule epithelial cells grown in traditional in vitro 2‐D culture systems do not maintain transporter and metabolic functions, thus limiting their ...
Kirk P, Van Ness +5 more
openaire +2 more sources
Integration of systems biology with organs-on-chips to humanize therapeutic development [PDF]
, 2017 "Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell ...
Chen, Wen Li +6 more
core +1 more source
Chip-based human liver-intestine and liver-skin co-culture : A first step toward systemic repeated dose substance testing in vitro [PDF]
, 2015 Systemic repeated dose safety assessment and systemic efficacy evaluation of substances are currently carried out on laboratory animals and in humans due to the lack of predictive alternatives.
Ayehunie, Seyoum +12 more
core +1 more source
Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems [PDF]
, 2015 Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation.
Cirit, Murat +2 more
core +1 more source
A microphysiological system model of therapy for liver micrometastases [PDF]
, 2014 Metastasis accounts for almost 90% of cancer-associated mortality. The effectiveness of cancer therapeutics is limited by the protective microenvironment of the metastatic niche and consequently these disseminated tumors remain incurable.
Borenstein, Jeffrey T. +12 more
core +1 more source
Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models [PDF]
, 2020 Natural tissues are incorporated with vasculature, which is further integrated with a cardiovascular system responsible for driving perfusion of nutrient‐rich oxygenated blood through the vasculature to support cell metabolism within most cell‐dense ...
Bonewald, Lynda F. +8 more
core +1 more source