Results 21 to 30 of about 4,549 (220)

Vascular microphysiological systems to model diseases [PDF]

Cell and Gene Therapy Insights, 2020
Human vascular microphysiological systems (MPS) represent promising three-dimensional in vitro models of normal and diseased vascular tissue. These systems build upon advances in tissue engineering, microfluidics, and stem cell differentiation and replicate key functional units of organs and tissues.
Qiao, Zhang, Xu, Zhang, George A, Truskey   +2 more
openaire   +2 more sources

A microphysiological model of bone development and regeneration [PDF]

, 2023
Endochondral ossification (EO) is an essential biological process than underpins how human bones develop, grow, and heal in the event of a fracture.
Kelly, Daniel J, Whelan, Ian T, Burdis, Ross, Shahreza, Somayeh, Moeendarbary, Emad, Hoey, David A   +5 more
core   +4 more sources

Human Mesenchymal Stem Cell‐Derived Miniature Joint System for Disease Modeling and Drug Testing

Advanced Science, 2022
Diseases of the knee joint such as osteoarthritis (OA) affect all joint elements. An in vitro human cell‐derived microphysiological system capable of simulating intraarticular tissue crosstalk is desirable for studying etiologies/pathogenesis of joint ...
Zhong Li, Zixuan Lin, Silvia Liu, Haruyo Yagi, Xiurui Zhang, Lauren Yocum, Monica Romero‐Lopez, Claire Rhee, Meagan J. Makarcyzk, Ilhan Yu, Eileen N. Li, Madalyn R. Fritch, Qi Gao, Kek Boon Goh, Benjamen O'Donnell, Tingjun Hao, Peter G. Alexander, Bhushan Mahadik, John P. Fisher, Stuart B. Goodman, Bruce A. Bunnell, Rocky S. Tuan, Hang Lin   +22 more
doaj   +1 more source

Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system [PDF]

, 2021
Kostrzewski et al. introduce an in vitro microphysiological model of non-alcoholic steatohepatitis (NASH), consisting of co-cultured primary human liver cells. The authors characterised the transcriptomic, inflammatory and fibrotic phenotype of the model
Surakala, M., Bornot, A., Battle, A. L., Clausen, M., Corrigan, A., Maass, C., Snow, S., Hughes, D., Ahmad, Z., Ryaboshapkina, M., Kostrzewski, T., Lindgren, J., Lindén, Daniel,, Basak, J., Peel, S., Young, L. M., Ewart, L.   +16 more
core   +1 more source

A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties [PDF]

, 2018
Distant metastasis is the major cause of breast cancer-related mortality, commonly emerging clinically after 5 or more years of seeming 'cure'of the primary tumor, indicating a quiescent dormancy.
Griffith, Linda G, Wheeler, S. E., Stolz, D. B., Young, Carissa L., Clark, Abigail M, Stockdale, Linda, Wells, A., Shepard, Nieman J., Zhao, Weian, Lauffenburger, Douglas A, Venkataramanan, R.   +10 more
core   +1 more source

Laser-induced cell injury in closed microphysiological systems: A novel method to study regeneration processes [PDF]

, 2022
S.S214Closed microphysiological systems are miniaturized, chip-sized platforms that can be used as cellularized organoid systems to study cellular processes like migration, regeneration or proliferation in-vitro.
Sradnick, Jan, Schmieder, Florian, Förster, Deborah, Hohenstein, Bernd, Sonntag, Frank   +4 more
core   +1 more source

Microphysiological Systems to Assess Nonclinical Toxicity [PDF]

Current Protocols in Toxicology, 2017
AbstractThe liver and the kidney are key toxicity target organs during drug development campaigns, as they typically carry the burden of drug transport and metabolism. Primary hepatocytes and proximal tubule epithelial cells grown in traditional in vitro 2‐D culture systems do not maintain transporter and metabolic functions, thus limiting their ...
Kirk P, Van Ness, Shih-Yu, Chang, Elijah J, Weber, Danielle, Zumpano, David L, Eaton, Edward J, Kelly   +5 more
openaire   +2 more sources

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System [PDF]

, 2018
In this work, we first describe the population variability in hepatic drug metabolism using cryopreserved hepatocytes from five different donors cultured in a perfused three-dimensional human liver microphysiological system, and then show how the ...
Griffith, Linda G, Hughes, D. J., Stokes, C. L., Cirit, Murat, Tsamandouras, Nikolaos, Kostrzewski, T.   +5 more
core   +1 more source

A microphysiological system model of therapy for liver micrometastases [PDF]

, 2014
Metastasis accounts for almost 90% of cancer-associated mortality. The effectiveness of cancer therapeutics is limited by the protective microenvironment of the metastatic niche and consequently these disseminated tumors remain incurable.
Borenstein, Jeffrey T., Taylor, Donald P., Stolz, Donna B., Wells, Alan, Wheeler, Sarah E., Nguyen, Transon, Young, Carissa L., Venkataramanan, Raman, Pillai, Venkateswaran C., Prantil-Baun, Rachelle, Clark, Amanda M., Griffith, Linda G., Lauffenburger, Douglas A.   +12 more
core   +1 more source

An Immunocompetent Microphysiological System to Simultaneously Investigate Effects of Anti-Tumor Natural Killer Cells on Tumor and Cardiac Microtissues

Frontiers in Immunology, 2021
Existing first-line cancer therapies often fail to cope with the heterogeneity and complexity of cancers, so that new therapeutic approaches are urgently needed.
Oanh T. P. Nguyen, Patrick M. Misun, Christian Lohasz, Jihyun Lee, Weijia Wang, Timm Schroeder, Andreas Hierlemann   +6 more
doaj   +1 more source