Results 11 to 20 of about 17,314,856 (225)
A Microphysiological System for Studying Nonalcoholic Steatohepatitis [PDF]
Hepatology Communications, 2020 Nonalcoholic steatohepatitis (NASH) is the most severe form of nonalcoholic fatty liver disease (NAFLD), which to date has no approved drug treatments. There is an urgent need for better understanding of the genetic and molecular pathways that underlie ...
Tomasz Kostrzewski +7 more
doaj +6 more sources
Gastrointestinal microphysiological systems [PDF]
Experimental Biology and Medicine, 2017 Gastrointestinal diseases are a significant health care and economic burden. Prevention and treatment of these diseases have been limited by the available human biologic models. Microphysiological systems comprise organ-specific human cultures that recapitulate many structural, biological, and functional properties of the organ in smaller scale ...
Sarah E, Blutt +9 more
openaire +3 more sources
Lab ChipCurrent preclinical models fail to capture human neutrophil-endothelial interactions central to sepsis, contributing to repeated failure of candidate therapeutics in clinical trials.
Liu D +7 more
europepmc +2 more sources
A microphysiological model of bone development and regeneration [PDF]
, 2023 Endochondral ossification (EO) is an essential biological process than underpins how human bones develop, grow, and heal in the event of a fracture.
Kelly, Daniel J +5 more
core +5 more sources
Biologically-Inspired Microphysiological Systems
, 2019 Microphysiological multi-organ devices are designed to mimic the physiological interaction of various interconnected organ models, by successfully imitating organismal functionality and response to substances. The first concepts of in vitro multi-organ systems were put forward in the late 1980s, demonstrating that such systems could provide mechanistic
Dehne, Eva Maria +2 more
openaire +3 more sources
Microphysiological Systems: A Pathologist’s Perspective [PDF]
Veterinary Pathology, 2020 High-throughput in vitro models lack human-relevant complexity, which undermines their ability to accurately mimic in vivo biologic and pathologic responses. The emergence of microphysiological systems (MPS) presents an opportunity to revolutionize in vitro modeling for both basic biomedical research and applied drug discovery.
Radhakrishna Sura +2 more
openaire +3 more sources
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing [PDF]
, 2018 The recent advent of microphysiological systems-microfluidic biomimetic devices that aspire to emulate the biology of human tissues, organs and circulation in vitro-promises to enable a global paradigm shift in drug development.
Cirit, Murat
core +4 more sources
Modeling immunity in microphysiological systems
Experimental Biology and Medicine, 2023 There is a need for better predictive models of the human immune system to evaluate safety and efficacy of immunomodulatory drugs and biologics for successful product development and regulatory approvals. Current in vitro models, which are often tested in two-dimensional (2D) tissue culture polystyrene, and preclinical animal models fail to fully ...
Brian J Kwee +5 more
openaire +2 more sources
Mera: A scalable high throughput automated micro-physiological system
SLAS Technology, 2023 There is an urgent need for scalable Microphysiological Systems (MPS's)11 Microphysiological systems (MPSs), Microtissue (MT), Polyetheretherketone (PEEK), Polytetrafluoroethylene (PTFE), Polystyrene (PS) that can better predict drug efficacy and ...
Finola E. Cliffe +12 more
doaj +1 more source
Vascular microphysiological systems to model diseases [PDF]
Cell and Gene Therapy Insights, 2020 Human vascular microphysiological systems (MPS) represent promising three-dimensional in vitro models of normal and diseased vascular tissue. These systems build upon advances in tissue engineering, microfluidics, and stem cell differentiation and replicate key functional units of organs and tissues.
Qiao, Zhang +2 more
openaire +2 more sources