Results 11 to 20 of about 4,549 (220)
A Microphysiological System for Studying Nonalcoholic Steatohepatitis [PDF]
Hepatology Communications, 2020 Nonalcoholic steatohepatitis (NASH) is the most severe form of nonalcoholic fatty liver disease (NAFLD), which to date has no approved drug treatments. There is an urgent need for better understanding of the genetic and molecular pathways that underlie ...
Tomasz Kostrzewski +7 more
doaj +6 more sources
Gastrointestinal microphysiological systems [PDF]
Experimental Biology and Medicine, 2017 Gastrointestinal diseases are a significant health care and economic burden. Prevention and treatment of these diseases have been limited by the available human biologic models.
Nicholas C Zachos +9 more
core +4 more sources
Stem cell-based vascularization of microphysiological systems [PDF]
Stem Cell Reports, 2021 Microphysiological systems (MPSs) (i.e., tissue or organ chips) exploit microfluidics and 3D cell culture to mimic tissue and organ-level physiology. The advent of human induced pluripotent stem cell (hiPSC) technology has accelerated the use of MPSs to ...
Healy, Kevin E +4 more
core +6 more sources
The Development of Controllable Magnetic Driven Microphysiological System [PDF]
Frontiers in Cell and Developmental Biology, 2019 Current research has enabled the use of microphysiological systems and creation of models for alveolar and pulmonary diseases. However, bottlenecks remain in terms of medium- and long-term regulation of cell cultures and their functions in microchannel ...
Jia-Wei Yang +19 more
doaj +3 more sources
Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing [PDF]
, 2018 The recent advent of microphysiological systems-microfluidic biomimetic devices that aspire to emulate the biology of human tissues, organs and circulation in vitro-promises to enable a global paradigm shift in drug development.
Cirit, Murat
core +6 more sources
Microphysiological Systems: A Pathologist’s Perspective [PDF]
Veterinary Pathology, 2020 High-throughput in vitro models lack human-relevant complexity, which undermines their ability to accurately mimic in vivo biologic and pathologic responses. The emergence of microphysiological systems (MPS) presents an opportunity to revolutionize in vitro modeling for both basic biomedical research and applied drug discovery.
Radhakrishna Sura +2 more
openaire +3 more sources
Modeling immunity in microphysiological systems
Experimental Biology and Medicine, 2023 There is a need for better predictive models of the human immune system to evaluate safety and efficacy of immunomodulatory drugs and biologics for successful product development and regulatory approvals. Current in vitro models, which are often tested in two-dimensional (2D) tissue culture polystyrene, and preclinical animal models fail to fully ...
Brian J Kwee +5 more
openaire +2 more sources
Breast Cancer Reconstruction: Design Criteria for a Humanized Microphysiological System [PDF]
, 2021 International regulatory agencies such as the Food and Drug Administration have mandated that the scientific community develop humanized microphysiological systems (MPS) as an alternative to animal models in the near future.
Frazier, Trivia +6 more
core +3 more sources
Gravity-Based Flow Efficient Perfusion Culture System for Spheroids Mimicking Liver Inflammation
Biomedicines, 2021 The spheroid culture system provides an efficient method to emulate organ-specific pathophysiology, overcoming the traditional two-dimensional (2D) cell culture limitations.
Young-Su Kim +5 more
doaj +1 more source
Nature Communications, 2022 In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules. Here the authors show that subjecting organoids to fluid shear stress in a PKD-on-a-chip microphysiological system promotes cyst expansion via an absorptive pathway.
Sienna R. Li +7 more
doaj +1 more source