Results 11 to 20 of about 6,388 (235)
A Microphysiological System for Studying Nonalcoholic Steatohepatitis [PDF]
Hepatology Communications, 2020 Nonalcoholic steatohepatitis (NASH) is the most severe form of nonalcoholic fatty liver disease (NAFLD), which to date has no approved drug treatments. There is an urgent need for better understanding of the genetic and molecular pathways that underlie ...
Tomasz Kostrzewski +7 more
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The Development of Controllable Magnetic Driven Microphysiological System [PDF]
Frontiers in Cell and Developmental Biology, 2019 Current research has enabled the use of microphysiological systems and creation of models for alveolar and pulmonary diseases. However, bottlenecks remain in terms of medium- and long-term regulation of cell cultures and their functions in microchannel ...
Jia-Wei Yang +19 more
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Microphysiological Systems: A Pathologist’s Perspective [PDF]
Veterinary Pathology, 2020 High-throughput in vitro models lack human-relevant complexity, which undermines their ability to accurately mimic in vivo biologic and pathologic responses. The emergence of microphysiological systems (MPS) presents an opportunity to revolutionize in vitro modeling for both basic biomedical research and applied drug discovery.
Radhakrishna Sura +2 more
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Gastrointestinal microphysiological systems [PDF]
Experimental Biology and Medicine, 2017 Gastrointestinal diseases are a significant health care and economic burden. Prevention and treatment of these diseases have been limited by the available human biologic models. Microphysiological systems comprise organ-specific human cultures that recapitulate many structural, biological, and functional properties of the organ in smaller scale ...
Sarah E, Blutt +9 more
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Modeling immunity in microphysiological systems
Experimental Biology and Medicine, 2023 There is a need for better predictive models of the human immune system to evaluate safety and efficacy of immunomodulatory drugs and biologics for successful product development and regulatory approvals. Current in vitro models, which are often tested in two-dimensional (2D) tissue culture polystyrene, and preclinical animal models fail to fully ...
Brian J Kwee +5 more
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Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system
Nano Convergence, 2021 Hepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure, and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in excessive extracellular matrix deposition and hepatic ...
Hafiz Muhammad Umer Farooqi +7 more
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Gravity-Based Flow Efficient Perfusion Culture System for Spheroids Mimicking Liver Inflammation
Biomedicines, 2021 The spheroid culture system provides an efficient method to emulate organ-specific pathophysiology, overcoming the traditional two-dimensional (2D) cell culture limitations.
Young-Su Kim +5 more
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Nature Communications, 2022 In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules. Here the authors show that subjecting organoids to fluid shear stress in a PKD-on-a-chip microphysiological system promotes cyst expansion via an absorptive pathway.
Sienna R. Li +7 more
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Vascular microphysiological systems to model diseases [PDF]
Cell and Gene Therapy Insights, 2020 Human vascular microphysiological systems (MPS) represent promising three-dimensional in vitro models of normal and diseased vascular tissue. These systems build upon advances in tissue engineering, microfluidics, and stem cell differentiation and replicate key functional units of organs and tissues.
Qiao, Zhang +2 more
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Frontiers in Immunology, 2021 Existing first-line cancer therapies often fail to cope with the heterogeneity and complexity of cancers, so that new therapeutic approaches are urgently needed.
Oanh T. P. Nguyen +6 more
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