Results 91 to 100 of about 6,641 (226)

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Patient-Derived Microphysiological Systems for Precision Medicine. [PDF]

Adv Healthc Mater, 2023
AbstractPatient‐derived microphysiological systems (P‐MPS) have emerged as powerful tools in precision medicine that provide valuable insight into individual patient characteristics. This review discusses the development of P‐MPS as an integration of patient‐derived samples, including patient‐derived cells, organoids, and induced pluripotent stem cells,
Ko J, Song J, Choi N, Kim HN.
europepmc   +3 more sources

Ten Quick Tips for Using a Raspberry Pi

, 2019
Much of biology (and, indeed, all of science) is becoming increasingly computational. We tend to think of this in regards to algorithmic approaches and software tools, as well as increased computing power.
Fletcher, Anthony C, Mura, Cameron
core   +1 more source

Systems toxicology: real world applications and opportunities [PDF]

, 2017
Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Amin Rostami-Hodjegan, Coecke S., Gary R. Mirams, Hartung T., Imran Shah, Manuel C. Peitsch, Martin F. Wilks, National Institute of Environmental Health Sciences, OECD, Paul Jennings, Rex E. FitzGerald, Shana J. Sturla, Thomas Hartung, van Vliet E., Wilmes A.   +14 more
core   +2 more sources

Foreword—Microphysiological Systems

Microphysiological Systems, 2017
It has been increasingly realized that the conventional planar cell cultures do not necessarily reproduce human physiology in vitro due to their limited ability to reproduce the structural and functional complexity of the in vivo counterparts, often resulting in biased outcomes of biological and pharmacological interrogations.
openaire   +1 more source

Developing Micro/Nanostructured Fluidic Mixing Technology for Biomedical Applications

Advanced Science, EarlyView.
This review critically evaluates how micro/nanostructured mixing technologies are redefining biomedical research. By synergizing fundamental analysis, numerical modeling, structural design, and external field manipulation, these systems attain unprecedented control over mass transport.
Junkai Wang, Hanxu Chen, Yile Fang, Yuanjin Zhao   +3 more
wiley   +1 more source

Big bottlenecks in cardiovascular tissue engineering. [PDF]

, 2018
Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of ...
Abilez, Oscar J, Huang, Ngan F, Morris, Viola B, Nakayama, Karina H, Pardon, Gaspard, Pruitt, Beth L, Sayed, Nazish, Serpooshan, Vahid, Wu, Joseph C, Wu, Sean M, Yoon, Young-Sup, Zhang, Jianyi   +11 more
core  

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine [PDF]

, 2019
A high throughput histology (microTMA) platform was applied for testing drugs against tumors in a novel 3D heterotypic glioblastoma brain sphere (gBS) model consisting of glioblastoma tumor cells, iPSC-derived neurons, glial cells and astrocytes grown in
Ball, Graeme, Hartung, Thomas, Lloyd, Roslyn, Pamies, David, Plummer, Simon, Quiñones-Hinojosa, Alfredo, Schiapparelli, Paula, Wallace, Stephanie   +7 more
core   +4 more sources

Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System

Advanced Electronic Materials, EarlyView.
This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella, Katelyn Neuman, Nolan Burson, Abigail N. Koppes, Ryan A. Koppes   +4 more
wiley   +1 more source

Modeling Toxoplasma gondii-gut early interactions using a human microphysiological system.

PLoS Neglected Tropical Diseases
Oral transmission of parasites via environmentally resistant cyst stages in contaminated food or water is a common route of human infection, but there are no effective vaccines available for any enteric parasitic infection. Our knowledge of parasite cyst
Carlos J Ramírez-Flores, Nicole D Hryckowian, Andrew N Gale, Kehinde Adebayo Babatunde, Marcos Lares, David J Beebe, Sheena C Kerr, Laura J Knoll   +7 more
doaj   +1 more source