Results 111 to 120 of about 8,980,611 (179)

Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Organoids are self‐organized, in vitro 3D structures derived from progenitor or pluripotent stem cells. During culture, these tissues secrete small extracellular vesicles (sEVs)—functional bioactive molecules—into their microenvironment. Here, we differentiated iPSC‐derived cerebral organoids (COs) under three culture conditions (static ...
Elifsu Polatlı, Burak Kahveci, Çağla Kiser, Nurhan Özlü, Gökhan Karakülah, Şermin Genç, Sinan Güven   +6 more
wiley   +1 more source

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

, 2018
The recent advent of microphysiological systems-microfluidic biomimetic devices that aspire to emulate the biology of human tissues, organs and circulation in vitro-promises to enable a global paradigm shift in drug development.
Cirit, Murat
core   +1 more source

Organoids: Current Applications and Future Directions

MedComm, Volume 7, Issue 10, October 2026.
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng, Yue Wang, Canhui Cao, Feng Deng, Weisi Lian, Xingtong Chen, Mingmei Lin, Zhonghong Zeng, Dan Mo, Shangqi Li, Yilei He, Yang Yu, Heng Pan, Ping Zhou, Rong Li   +14 more
wiley   +1 more source

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, Volume 81, Issue 10, Page 3488-3503, October 2026.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, Volume 604, Issue 19, Page 8069-8099, 1 October 2026.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source

Towards more effective testing of communications-critical large scale systems [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.A publication based on the research from this thesis has been published and can be cited as Nabulsi, MA and Hierons, RM (2014), A new test framework for ...
Nabulsi, Mohammad
core   +1 more source

An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery

Microsystems & Nanoengineering
Physiological supporting systems, such as the vascular network and excretion system, are crucial for the effective functioning of organs. This study demonstrates that when a body-on-a-chip microdevice is coupled with miniaturized physiological support ...
Jing Wang, Huixue Zhang, Yueyang Qu, Yang Yang, Shuhui Xu, Zhenni Ji, Yuxiu Wang, Xiuli Zhang, Yong Luo   +8 more
doaj   +1 more source

Estradiol and dihydrotestosterone exert sex-specific effects on human fibroblast and endothelial proliferation, bioenergetics, and vasculogenesis

Communications Biology
Sex-specific cell culture methods and microphysiological systems can enhance our understanding of how biological sex influences health and disease. Here, we investigated the effects of estradiol and dihydrotestosterone on primary human lung and ocular ...
Ashley T. Martier, Yasmin V. Maurice, K. Michael Conrad, Delia A. Carlino, Franck Mauvais-Jarvis, Mark J. Mondrinos   +5 more
doaj   +1 more source

Microphysiological systems

APL Bioengineering, 2019
James J. Hickman, Dongeun Huh, Roger D. Kamm   +2 more
doaj   +1 more source

Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit

Journal of Neurodevelopmental Disorders
Background Tuberous sclerosis complex (TSC) is a multi-system genetic disease that causes benign tumors in the brain and other vital organs. The most debilitating symptoms result from involvement of the central nervous system and lead to a multitude of ...
Jacquelyn A. Brown, Shannon L. Faley, Monika Judge, Patricia Ward, Rebecca A. Ihrie, Robert Carson, Laura Armstrong, Mustafa Sahin, John P. Wikswo, Kevin C. Ess, M. Diana Neely   +10 more
doaj   +1 more source