Results 111 to 120 of about 6,641 (226)

Cardiac Meets Skeletal: What's New in Microfluidic Models for Muscle Tissue Engineering [PDF]

, 2016
In the last few years microfluidics and microfabrication technique principles have been extensively exploited for biomedical applications. In this framework, organs-on-a-chip represent promising tools to reproduce key features of functional tissue units ...
Bersini, Simone, Gilardi, Mara, Marsano, Anna, Moretti, Matteo, Rasponi, Marco, Visone, Roberta   +5 more
core   +2 more sources

Microphysiological system as a promising technology for drug assay

Folia Pharmacologica Japonica, 2019
MPS (microphysiological system) is in-vitro cell-culture environment, which is precisely maintained in a micro space manufactured using MEMS (micro electro mechanical systems) technology, to derive in-vivo like functions from human cells. From the viewpoint of pharmacokinetics, it can be considered as a wet PBPK/PD simulator consisting of the micro ...
Seiichi, Ishida, Toshiyuki, Kanamori
openaire   +3 more sources

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

VIEW, EarlyView.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder, Kacy Greenhalgh, Joanna Baginska, Camille Martin‐Gallausiaux, Léa Grandmougin, Rémy Villette, Mara Lucchetti, Bérénice Hansen, Marek Ostaszewski, Viacheslav A. Petrov, Koji Atarashi, Lena Weidert, Audrey Frachet Bour, Dominik Ternes, Javier Ramiro‐Garcia, Antoine Malabirade, Takeshi Tanoue, Marc Mac Giolla Eain, Elisabeth Letellier, Matthew Barrett, Jérôme Lacombe, Frederic Zenhausern, Coralie Guérin, Markus Ollert, Carole Seguin‐Devaux, Kenya Honda, Paul Wilmes   +26 more
wiley   +1 more source

Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations [PDF]

, 2018
A smart sensor system for cell culture real-time supervision is proposed, allowing for a significant reduction in human effort applied to this type of assay. The approach converts the cell culture under test into a suitable “biological” oscillator.
Daza Navarro, María Paula, Huertas Sánchez, Gloria, Maldonado-Jacobi, Andrés, Martín Rubio, María Esther, Olmo Fernández, Alberto, Pérez García, Pablo, Rueda Rueda, Adoración (Coordinador), Serrano Viseas, Juan Alfonso, Sánchez Aguayo, Inmaculada (Coordinador), Yúfera García, Alberto   +9 more
core  

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

On-Chip AC Electrothermal Pump for Pulsatile Perfusion

Micromachines
Microphysiological systems (MPSs) have emerged as promising platforms for drug discovery and in vitro pharmacological testing. MPSs aid to reproduce physiologically relevant microenvironments, in which controlled perfusion can play important role.
Itaru Kawata, Sosuke Kobayashi, Yoshiyasu Ichikawa, Masahiro Motosuke   +3 more
doaj   +1 more source

Evaluating biomaterial-and microfluidic-based 3D tumor models [PDF]

, 2015
Cancer is a major cause of morbidity and mortality worldwide, with a disease burden estimated to increase in the coming decades. Disease heterogeneity and limited information on cancer biology and disease mechanisms are aspects that 2D cell cultures fail
Carvalho, Mariana R., Correlo, V. M., Lima, Daniela, Oliveira, J. M., Reis, R. L.   +4 more
core   +1 more source

A microphysiological systems approach to design gastrointestinal system

Journal of Biomaterials Science, Polymer Edition
The gastrointestinal (GI) system is a complex and dynamic organ system, with the anatomy and varied physiological functionality adding complexity to nutrient absorption, immune function, and maintenance of overall health. This review begins with an overview of the anatomy, highlighting key organs and their respective roles, followed by an exploration ...
Vidhi Mathur, Mrunmayi Gadre, Amrutha H. K., Kirthanashri S. Vasanthan   +3 more
openaire   +2 more sources

The use of microphysiological systems to model metastatic cancer [PDF]

Biofabrication
Abstract Cancer is one of the leading causes of death in the 21st century, with metastasis of cancer attributing to 90% of cancer-related deaths. Therefore, to improve patient outcomes there is a need for better preclinical models to increase the success of translating oncological therapies into the clinic.
Caitlin E Jackson, Nicola H Green, William R English, Frederik Claeyssens   +3 more
openaire   +4 more sources