Results 31 to 40 of about 4,082 (188)

Rapid Prototyping of Multilayer Microphysiological Systems

ACS Biomaterials Science & Engineering, 2020
Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared to traditional two-dimensional (2D) static cell culture. Often such devices are fabricated via poly(dimethylsiloxane) (PDMS) soft lithography, which offers benefits (e.g., high feature resolution) along with drawbacks (e.g., prototyping time/costs).
Sanjin Hosic, Adam J. Bindas, Marissa L. Puzan, Will Lake, Jonathan R. Soucy, Fanny Zhou, Ryan A. Koppes, David T. Breault, Shashi K. Murthy, Abigail N. Koppes   +9 more
openaire   +3 more sources

Omics of endothelial cell dysfunction in sepsis

Vascular Biology, 2022
During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, resulting in ...
Jordan C Langston, Michael T Rossi, Qingliang Yang, William Ohley, Edwin Perez, Laurie E Kilpatrick, Balabhaskar Prabhakarpandian, Mohammad F Kiani   +7 more
doaj   +1 more source

Split Ends Inhibits the Dedifferentiation of imINP to Prevent the Generation of Supernumerary Type II Neuroblasts in Drosophila

Cells
Investigating the mechanisms that maintain different types of neural stem cells is essential for brain development. While factors maintaining distinct Drosophila melanogaster neuroblasts (NBs) have been identified, additional factors remain unidentified.
Qingxia Zhou, Fuhao Zhang, Sifan Gong, Shuliu Zhang, Wenting Gong, Menglong Rui, Su Wang   +6 more
doaj   +1 more source

Force sensing of hepatic stellate cell in real-time with photonic crystal cellular force microscopy

EngMedicine
The contractile force exerted by hepatic stellate cells (HSCs) plays a critical role in both physiological and pathological processes in the liver.
Xuan Sun, Zilin Zhang, Nankun Xiong, Shihui Xu, Wentao Zhao, Yan Wang, Boyang Song, Qiwei Li, Zhongze Gu, Zaozao Chen   +9 more
doaj   +1 more source

Modular Microphysiological System for Modeling of Biologic Barrier Function

Frontiers in Bioengineering and Biotechnology, 2020
Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,
Matthew Ishahak, Jordan Hill, Quratulain Amin, Laura Wubker, Adiel Hernandez, Alla Mitrofanova, Alexis Sloan, Alessia Fornoni, Alessia Fornoni, Ashutosh Agarwal, Ashutosh Agarwal   +10 more
doaj   +1 more source

3D printed scaffolds: Challenges toward developing relevant cellular in vitro models

Biomaterials and Biosystems, 2022
Three-dimensional (3D) cell culture technology has rapidly emerged, as a result of the increasing demand for improved in vitro systems that better resemble human physiology.
Beatriz Molina-Martínez, Luis M. Liz-Marzán   +1 more
doaj   +1 more source

Engineering and monitoring cellular barrier models

Journal of Biological Engineering, 2018
Epithelia and endothelia delineate tissue compartments and control their environments by regulating the passage of ions and solutes. This barrier function is essential for the development and maintenance of multicellular organisms, and its dysfunction is
Jose Yeste, Xavi Illa, Mar Alvarez, Rosa Villa   +3 more
doaj   +1 more source

A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses

Advanced Healthcare Materials, EarlyView.
This study presents a novel 3D Neuron‐on‐Chip model that can maintain human PSC‐derived excitatory prefrontal cortex neurons in 3D hydrogels and can be used to monitor neuronal injury responses over time. Results show injury‐induced acute neuronal excitotoxicity, declining neuronal connectivity, and the activation of a neurodegenerative, SASP‐like ...
Ruiping Tang, Charles‐Francois Latchoumane, Avi Chopra, Md Marzan Sarkar, Chunki Kim, Nathan Gonsalves, Hsueh‐Fu Wu, John C. Sentmanat, Alan Liu, Isha Mhatre‐Winters, Aditya Mishra, Andrei G. Fedorov, Jay M. Patel, Nadja Zeltner, Steven L. Stice, Jason R. Richardson, Lohitash Karumbaiah   +16 more
wiley   +1 more source

Computation strategies and clinical applications in neoantigen discovery towards precision cancer immunotherapy

Biomarker Research
Neoantigens, which are tumor-specific peptides generated by malignant cells, can be presented to T cells to elicit immune responses. Owing to their tumor-specific properties, neoantigens have emerged as one of the most promising biomarkers and targets ...
Zhenchang Wang, Yu Gu, Xiao Sun, Hao Huang   +3 more
doaj   +1 more source

Modeling early stage atherosclerosis in a primary human vascular microphysiological system

Nature Communications, 2020
Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of several
Xu Zhang, Muath Bishawi, Ge Zhang, Varun Prasad, Ellen Salmon, Jason J. Breithaupt, Qiao Zhang, George A. Truskey   +7 more
doaj   +1 more source