Results 31 to 40 of about 4,031 (174)

3D printed scaffolds: Challenges toward developing relevant cellular in vitro models

Biomaterials and Biosystems, 2022
Three-dimensional (3D) cell culture technology has rapidly emerged, as a result of the increasing demand for improved in vitro systems that better resemble human physiology.
Beatriz Molina-Martínez, Luis M. Liz-Marzán   +1 more
doaj   +1 more source

Stem cell-based vascularization of microphysiological systems [PDF]

Stem Cell Reports, 2021
Microphysiological systems (MPSs) (i.e., tissue or organ chips) exploit microfluidics and 3D cell culture to mimic tissue and organ-level physiology. The advent of human induced pluripotent stem cell (hiPSC) technology has accelerated the use of MPSs to study human disease in a range of organ systems. However, in the reduction of system complexity, the
Browne, Shane, Gill, Elisabeth L, Schultheiss, Paula, Goswami, Ishan, Healy, Kevin E   +4 more
openaire   +4 more sources

Split Ends Inhibits the Dedifferentiation of imINP to Prevent the Generation of Supernumerary Type II Neuroblasts in Drosophila

Cells
Investigating the mechanisms that maintain different types of neural stem cells is essential for brain development. While factors maintaining distinct Drosophila melanogaster neuroblasts (NBs) have been identified, additional factors remain unidentified.
Qingxia Zhou, Fuhao Zhang, Sifan Gong, Shuliu Zhang, Wenting Gong, Menglong Rui, Su Wang   +6 more
doaj   +1 more source

Modeling early stage atherosclerosis in a primary human vascular microphysiological system

Nature Communications, 2020
Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of several
Xu Zhang, Muath Bishawi, Ge Zhang, Varun Prasad, Ellen Salmon, Jason J. Breithaupt, Qiao Zhang, George A. Truskey   +7 more
doaj   +1 more source

Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses

Communications Biology, 2021
Alave-Furrer et al adapted their recently-developed 3D bioprinting platform to allow microvalve-based drop-on-demand printing of cell-laden Matrigel containing primary human muscle precursor cells.
Angela Alave Reyes-Furrer, Sonia De Andrade, Dominic Bachmann, Heidi Jeker, Martin Steinmann, Nathalie Accart, Andrew Dunbar, Martin Rausch, Epifania Bono, Markus Rimann, Hansjoerg Keller   +10 more
doaj   +1 more source

Modelling the innate immune system in microphysiological systems.

Lab Chip
Integration of an immune component moves the field closer to a physiologically relevant human-on-a-chip.
Rupar MJ, Hanson H, Rogers S, Botlick B, Trimmer S, Hickman JJ.   +5 more
europepmc   +3 more sources

Force sensing of hepatic stellate cell in real-time with photonic crystal cellular force microscopy

EngMedicine
The contractile force exerted by hepatic stellate cells (HSCs) plays a critical role in both physiological and pathological processes in the liver.
Xuan Sun, Zilin Zhang, Nankun Xiong, Shihui Xu, Wentao Zhao, Yan Wang, Boyang Song, Qiwei Li, Zhongze Gu, Zaozao Chen   +9 more
doaj   +1 more source

Engineering and monitoring cellular barrier models

Journal of Biological Engineering, 2018
Epithelia and endothelia delineate tissue compartments and control their environments by regulating the passage of ions and solutes. This barrier function is essential for the development and maintenance of multicellular organisms, and its dysfunction is
Jose Yeste, Xavi Illa, Mar Alvarez, Rosa Villa   +3 more
doaj   +1 more source

Mera: A scalable high throughput automated micro-physiological system

SLAS Technology, 2023
There is an urgent need for scalable Microphysiological Systems (MPS's)11 Microphysiological systems (MPSs), Microtissue (MT), Polyetheretherketone (PEEK), Polytetrafluoroethylene (PTFE), Polystyrene (PS) that can better predict drug efficacy and ...
Finola E. Cliffe, Conor Madden, Patrick Costello, Shane Devitt, Sumir Ramesh Mukkunda, Bhairavi Bengaluru Keshava, Howard O. Fearnhead, Aiste Vitkauskaite, Mahshid H. Dehkordi, Walter Chingwaru, Milosz Przyjalgowski, Natalia Rebrova, Mark Lyons   +12 more
doaj   +1 more source

Augmented 3D Printing for Multiscale Microphysiological Systems. [PDF]

Small
Abstract Microphysiological systems (MPS) can recapitulate physiological features of human organs; however, existing engineering techniques are limited to fabricating sophisticated and functional MPS. Although 3D printing offers the potential to enhance the complexity of MPS and simplify the fabrication process, existing 3D‐printed ...
Hwang KS, Song J, Kang HW, Kim J, Ha CW, Choi N, Bang S, Kim HN.   +7 more
europepmc   +4 more sources