Results 31 to 40 of about 6,641 (226)
Microphysiological systems for human aging research. [PDF]
Aging CellAbstractRecent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip (OoC), enable the recapitulation of more complex organ and tissue functions on a smaller scale in vitro. MPS therefore provide the potential to better understand human diseases and physiology.
Park S +5 more
europepmc +3 more sources
Importance of vesicle release stochasticity in neuro-spike communication. [PDF]
, 2017 Aim of this paper is proposing a stochastic model for vesicle release process, a part of neuro-spike communication. Hence, we study biological events occurring in this process and use microphysiological simulations to observe functionality of these ...
Akan, Ozgur B, Ramezani, Hamideh
core +1 more source
Omics of endothelial cell dysfunction in sepsis
Vascular Biology, 2022 During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, resulting in ...
Jordan C Langston +7 more
doaj +1 more source
Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration [PDF]
, 2015 Our goal in developing Microphysiological Systems (MPS) technology is to provide an improved approach for more predictive preclinical drug discovery via a highly integrated experimental/computational paradigm.
Cilfone, Nicholas A. +10 more
core +1 more source
A microphysiological system model of therapy for liver micrometastases [PDF]
, 2014 Metastasis accounts for almost 90% of cancer-associated mortality. The effectiveness of cancer therapeutics is limited by the protective microenvironment of the metastatic niche and consequently these disseminated tumors remain incurable.
Borenstein, Jeffrey T. +12 more
core +1 more source
Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells [PDF]
, 2015 Purpose: The lung is one of the most common sites of breast cancer metastasis. While metastatic seeding is often accompanied by a dormancy-promoting mesenchymal to epithelial reverting transitions (MErT), we aimed to determine whether lung epithelial ...
Clark, AM +3 more
core +7 more sources
APL Bioengineering, 2019 Complex in vitro models of the tissue microenvironment, termed microphysiological systems, have enormous potential to transform the process of discovering drugs and disease mechanisms.
Hannah Viola +6 more
doaj +1 more source
Modular Microphysiological System for Modeling of Biologic Barrier Function
Frontiers in Bioengineering and Biotechnology, 2020 Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,
Matthew Ishahak +10 more
doaj +1 more source
Maximizing the Impact of Microphysiological Systems with in Vitro–in Vivo Translation [PDF]
, 2018 Microphysiological systems (MPS) hold promise for improving therapeutic drug approval rates by providing more physiological, human-based, in vitro assays for preclinical drug development activities compared to traditional in vitro and animal models. Here,
Cirit, Murat, Stokes, Cynthia L.
core +1 more source
Stem cell-based vascularization of microphysiological systems [PDF]
Stem Cell Reports, 2021 Microphysiological systems (MPSs) (i.e., tissue or organ chips) exploit microfluidics and 3D cell culture to mimic tissue and organ-level physiology. The advent of human induced pluripotent stem cell (hiPSC) technology has accelerated the use of MPSs to study human disease in a range of organ systems. However, in the reduction of system complexity, the
Browne, Shane +4 more
openaire +4 more sources