Results 31 to 40 of about 8,980,611 (179)

Modular Microphysiological System for Modeling of Biologic Barrier Function

Frontiers in Bioengineering and Biotechnology, 2020
Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,
Matthew Ishahak, Jordan Hill, Quratulain Amin, Laura Wubker, Adiel Hernandez, Alla Mitrofanova, Alexis Sloan, Alessia Fornoni, Alessia Fornoni, Ashutosh Agarwal, Ashutosh Agarwal   +10 more
doaj   +1 more source

Biologically-Inspired Microphysiological Systems

, 2018
Microphysiological multi-organ devices are designed to mimic the physiological interaction of various interconnected organ models, by successfully imitating organismal functionality and response to substances.
Eva-Maria Dehne, Shuler, Michael, Hickman, James, Michael Shuler, James Hickman, Dehne, Eva Maria   +5 more
core   +1 more source

Engineering and monitoring cellular barrier models

Journal of Biological Engineering, 2018
Epithelia and endothelia delineate tissue compartments and control their environments by regulating the passage of ions and solutes. This barrier function is essential for the development and maintenance of multicellular organisms, and its dysfunction is
Jose Yeste, Xavi Illa, Mar Alvarez, Rosa Villa   +3 more
doaj   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems

, 2017
Liver disease represents a growing global health burden. The development of in vitro liver models which allow the study of disease and the prediction of metabolism and drug-induced liver injury in humans remains a challenge.
David J Hughes, Emma L Sceats, Tomasz Kostrzewski   +2 more
core   +1 more source

Computation strategies and clinical applications in neoantigen discovery towards precision cancer immunotherapy

Biomarker Research
Neoantigens, which are tumor-specific peptides generated by malignant cells, can be presented to T cells to elicit immune responses. Owing to their tumor-specific properties, neoantigens have emerged as one of the most promising biomarkers and targets ...
Zhenchang Wang, Yu Gu, Xiao Sun, Hao Huang   +3 more
doaj   +1 more source

Modeling early stage atherosclerosis in a primary human vascular microphysiological system

Nature Communications, 2020
Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of several
Xu Zhang, Muath Bishawi, Ge Zhang, Varun Prasad, Ellen Salmon, Jason J. Breithaupt, Qiao Zhang, George A. Truskey   +7 more
doaj   +1 more source

3D printed scaffolds: Challenges toward developing relevant cellular in vitro models

Biomaterials and Biosystems, 2022
Three-dimensional (3D) cell culture technology has rapidly emerged, as a result of the increasing demand for improved in vitro systems that better resemble human physiology.
Beatriz Molina-Martínez, Luis M. Liz-Marzán   +1 more
doaj   +1 more source

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

Vascular microphysiological systems. [PDF]

Curr Opin Hematol
PURPOSE OF REVIEW: This review summarizes innovations in vascular microphysiological systems (MPS) and discusses the themes that have emerged from recent works.
Shelton SE.
europepmc   +2 more sources