Results 21 to 30 of about 4,082 (188)
Autologous Human Immunocompetent White Adipose Tissue‐on‐Chip
Advanced Science, 2022 Obesity and associated diseases, such as diabetes, have reached epidemic proportions globally. In this era of “diabesity”, white adipose tissue (WAT) has become a target of high interest for therapeutic strategies.
Julia Rogal +8 more
doaj +1 more source
Animal Model Alternatives in Filovirus and Bornavirus Research
Viruses, 2023 The order Mononegavirales contains a variety of highly pathogenic viruses that may infect humans, including the families Filoviridae, Bornaviridae, Paramyxoviridae, and Rhabodoviridae.
Lina Widerspick +3 more
doaj +1 more source
Application of microphysiological systems to unravel the mechanisms of schistosomiasis egg extravasation. [PDF]
Front Cell Infect MicrobiolAlfred MO +7 more
europepmc +2 more sources
3D organ-on-a-chip: The convergence of microphysiological systems and organoids
Frontiers in Cell and Developmental Biology, 2022 Medicine today faces the combined challenge of an increasing number of untreatable diseases and fewer drugs reaching the clinic. While pharmaceutical companies have increased the number of drugs in early development and entering phase I of clinical ...
Leandra S. Baptista +9 more
doaj +1 more source
Microphysiological Systems to Assess Nonclinical Toxicity [PDF]
Current Protocols in Toxicology, 2017 AbstractThe liver and the kidney are key toxicity target organs during drug development campaigns, as they typically carry the burden of drug transport and metabolism. Primary hepatocytes and proximal tubule epithelial cells grown in traditional in vitro 2‐D culture systems do not maintain transporter and metabolic functions, thus limiting their ...
Kirk P, Van Ness +5 more
openaire +2 more sources
A Microphysiological System for Studying Nonalcoholic Steatohepatitis [PDF]
Hepatology Communications, 2019 Nonalcoholic steatohepatitis (NASH) is the most severe form of nonalcoholic fatty liver disease (NAFLD), which to date has no approved drug treatments. There is an urgent need for better understanding of the genetic and molecular pathways that underlie NAFLD/NASH, and currently available preclinical models, be they
Kostrzewski, T +7 more
openaire +4 more sources
Microphysiological systems for solid tumor immunotherapy: opportunities and challenges
Microsystems & Nanoengineering, 2023 Immunotherapy remains more effective for hematologic tumors than for solid tumors. One of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate, which limits the cytotoxic capabilities of ...
Sara Abizanda-Campo +7 more
doaj +1 more source
APL Bioengineering, 2019 Complex in vitro models of the tissue microenvironment, termed microphysiological systems, have enormous potential to transform the process of discovering drugs and disease mechanisms.
Hannah Viola +6 more
doaj +1 more source
Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system
Nano Convergence, 2021 Hepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure, and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in excessive extracellular matrix deposition and hepatic ...
Hafiz Muhammad Umer Farooqi +7 more
doaj +1 more source
Microphysiologic systems in female reproductive biology [PDF]
Experimental Biology and Medicine, 2017 Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a ...
Alexandria N, Young +3 more
openaire +2 more sources