Results 21 to 30 of about 8,980,611 (179)

Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems [PDF]

, 2015
Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation.
Stokes, CL, Cirit, Murat, Lauffenburger, Douglas A   +2 more
core   +1 more source

Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair

APL Bioengineering, 2019
Complex in vitro models of the tissue microenvironment, termed microphysiological systems, have enormous potential to transform the process of discovering drugs and disease mechanisms.
Hannah Viola, Jonathan Chang, Jocelyn R. Grunwell, Louise Hecker, Rabindra Tirouvanziam, James B. Grotberg, Shuichi Takayama   +6 more
doaj   +1 more source

Laser-induced cell injury in closed microphysiological systems: A novel method to study regeneration processes

, 2022
S.S214Closed microphysiological systems are miniaturized, chip-sized platforms that can be used as cellularized organoid systems to study cellular processes like migration, regeneration or proliferation in-vitro.
Sradnick, Jan, Schmieder, Florian, Förster, Deborah, Hohenstein, Bernd, Sonntag, Frank   +4 more
core   +1 more source

Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system

Nano Convergence, 2021
Hepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure, and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in excessive extracellular matrix deposition and hepatic ...
Hafiz Muhammad Umer Farooqi, Bohye Kang, Muhammad Asad Ullah Khalid, Abdul Rahim Chethikkattuveli Salih, Kinam Hyun, Sung Hyuk Park, Dongeun Huh, Kyung Hyun Choi   +7 more
doaj   +1 more source

Omics of endothelial cell dysfunction in sepsis

Vascular Biology, 2022
During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, resulting in ...
Jordan C Langston, Michael T Rossi, Qingliang Yang, William Ohley, Edwin Perez, Laurie E Kilpatrick, Balabhaskar Prabhakarpandian, Mohammad F Kiani   +7 more
doaj   +1 more source

Facile photopatterning of perfusable microchannels in hydrogels for microphysiological systems. [PDF]

Nat Protoc
Perfusable hydrogels have garnered substantial attention in recent years for the fabrication of microphysiological systems. However, current methodologies to fabricate microchannels in hydrogel platforms involve sophisticated equipment and techniques ...
Mora-Boza A, Mulero-Russe A, Di Caprio N, Burdick JA, O'Neill E, Singh A, García AJ.   +6 more
europepmc   +2 more sources

Application of microphysiological systems to unravel the mechanisms of schistosomiasis egg extravasation. [PDF]

Front Cell Infect Microbiol
Alfred MO, Ochola L, Okeyo K, Bae E, Ogongo P, Odongo D, Njaanake K, Robinson JP.   +7 more
europepmc   +2 more sources

Split Ends Inhibits the Dedifferentiation of imINP to Prevent the Generation of Supernumerary Type II Neuroblasts in Drosophila

Cells
Investigating the mechanisms that maintain different types of neural stem cells is essential for brain development. While factors maintaining distinct Drosophila melanogaster neuroblasts (NBs) have been identified, additional factors remain unidentified.
Qingxia Zhou, Fuhao Zhang, Sifan Gong, Shuliu Zhang, Wenting Gong, Menglong Rui, Su Wang   +6 more
doaj   +1 more source

Force sensing of hepatic stellate cell in real-time with photonic crystal cellular force microscopy

EngMedicine
The contractile force exerted by hepatic stellate cells (HSCs) plays a critical role in both physiological and pathological processes in the liver.
Xuan Sun, Zilin Zhang, Nankun Xiong, Shihui Xu, Wentao Zhao, Yan Wang, Boyang Song, Qiwei Li, Zhongze Gu, Zaozao Chen   +9 more
doaj   +1 more source

Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems [PDF]

, 2014
Gastrointestinal illnesses are a significant health burden for the US population, with 40 million office visits each year for gastrointestinal complaints and nearly 250,000 deaths.
Hartman, Kira G, Jhala, Nirag, Yu, Jian, Lynch, John P, Martín, Martín G, Falk, Gary W, Bortner, James D, Ginsberg, Gregory G, Rustgi, Anil K   +8 more
core   +1 more source