Application of microphysiological systems to unravel the mechanisms of schistosomiasis egg extravasation. [PDF]
Front Cell Infect MicrobiolAlfred MO +7 more
europepmc +2 more sources
A Microphysiological System for Studying Nonalcoholic Steatohepatitis [PDF]
Hepatology Communications, 2019 Nonalcoholic steatohepatitis (NASH) is the most severe form of nonalcoholic fatty liver disease (NAFLD), which to date has no approved drug treatments. There is an urgent need for better understanding of the genetic and molecular pathways that underlie NAFLD/NASH, and currently available preclinical models, be they
Kostrzewski, T +7 more
openaire +4 more sources
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]
, 2013 Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D +6 more
core +2 more sources
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies [PDF]
, 2018 Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion.
Brij M. Bhushan +37 more
core +2 more sources
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies [PDF]
, 2017 Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development, and therefore several in vitro systems are routinely employed for this purpose.
Chen, Wen Li +5 more
core +2 more sources
Integration of systems biology with organs-on-chips to humanize therapeutic development [PDF]
, 2017 "Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell ...
Chen, Wen Li +6 more
core +1 more source
Microphysiological Systems to Assess Nonclinical Toxicity [PDF]
Current Protocols in Toxicology, 2017 AbstractThe liver and the kidney are key toxicity target organs during drug development campaigns, as they typically carry the burden of drug transport and metabolism. Primary hepatocytes and proximal tubule epithelial cells grown in traditional in vitro 2‐D culture systems do not maintain transporter and metabolic functions, thus limiting their ...
Kirk P, Van Ness +5 more
openaire +2 more sources
Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems [PDF]
, 2015 Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation.
Cirit, Murat +2 more
core +1 more source
Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system
Nano Convergence, 2021 Hepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure, and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in excessive extracellular matrix deposition and hepatic ...
Hafiz Muhammad Umer Farooqi +7 more
doaj +1 more source
Chip-based human liver-intestine and liver-skin co-culture : A first step toward systemic repeated dose substance testing in vitro [PDF]
, 2015 Systemic repeated dose safety assessment and systemic efficacy evaluation of substances are currently carried out on laboratory animals and in humans due to the lack of predictive alternatives.
Ayehunie, Seyoum +12 more
core +1 more source