Results 21 to 30 of about 4,031 (174)
Application of microphysiological systems to unravel the mechanisms of schistosomiasis egg extravasation. [PDF]
Front Cell Infect MicrobiolAlfred MO +7 more
europepmc +2 more sources
Microphysiological Systems to Assess Nonclinical Toxicity [PDF]
Current Protocols in Toxicology, 2017 AbstractThe liver and the kidney are key toxicity target organs during drug development campaigns, as they typically carry the burden of drug transport and metabolism. Primary hepatocytes and proximal tubule epithelial cells grown in traditional in vitro 2‐D culture systems do not maintain transporter and metabolic functions, thus limiting their ...
Kirk P, Van Ness +5 more
openaire +2 more sources
Microphysiological systems for solid tumor immunotherapy: opportunities and challenges
Microsystems & Nanoengineering, 2023 Immunotherapy remains more effective for hematologic tumors than for solid tumors. One of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate, which limits the cytotoxic capabilities of ...
Sara Abizanda-Campo +7 more
doaj +1 more source
Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system
Nano Convergence, 2021 Hepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure, and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in excessive extracellular matrix deposition and hepatic ...
Hafiz Muhammad Umer Farooqi +7 more
doaj +1 more source
Omics of endothelial cell dysfunction in sepsis
Vascular Biology, 2022 During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, resulting in ...
Jordan C Langston +7 more
doaj +1 more source
Microphysiologic systems in female reproductive biology [PDF]
Experimental Biology and Medicine, 2017 Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a ...
Alexandria N, Young +3 more
openaire +2 more sources
APL Bioengineering, 2019 Complex in vitro models of the tissue microenvironment, termed microphysiological systems, have enormous potential to transform the process of discovering drugs and disease mechanisms.
Hannah Viola +6 more
doaj +1 more source
Rapid Prototyping of Multilayer Microphysiological Systems
ACS Biomaterials Science & Engineering, 2020 Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared to traditional two-dimensional (2D) static cell culture. Often such devices are fabricated via poly(dimethylsiloxane) (PDMS) soft lithography, which offers benefits (e.g., high feature resolution) along with drawbacks (e.g., prototyping time/costs).
Sanjin Hosic +9 more
openaire +3 more sources
Modular Microphysiological System for Modeling of Biologic Barrier Function
Frontiers in Bioengineering and Biotechnology, 2020 Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,
Matthew Ishahak +10 more
doaj +1 more source
Microphysiological systems for human aging research. [PDF]
Aging CellAbstractRecent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip (OoC), enable the recapitulation of more complex organ and tissue functions on a smaller scale in vitro. MPS therefore provide the potential to better understand human diseases and physiology.
Park S +5 more
europepmc +3 more sources