Results 11 to 20 of about 4,031 (174)
Microphysiological Systems for Neurodegenerative Diseases in Central Nervous System [PDF]
Micromachines, 2020 Neurodegenerative diseases are among the most severe problems in aging societies. Various conventional experimental models, including 2D and animal models, have been used to investigate the pathogenesis of (and therapeutic mechanisms for ...
Mihyeon Bae +3 more
doaj +4 more sources
Microphysiological systems [PDF]
APL Bioengineering, 2019 James J. Hickman +2 more
doaj +3 more sources
Modeling immunity in microphysiological systems. [PDF]
Exp Biol Med (Maywood), 2023 There is a need for better predictive models of the human immune system to evaluate safety and efficacy of immunomodulatory drugs and biologics for successful product development and regulatory approvals. Current in vitro models, which are often tested in two-dimensional (2D) tissue culture polystyrene, and preclinical animal models fail to fully ...
Kwee BJ +5 more
europepmc +3 more sources
Microphysiological Systems: A Pathologist’s Perspective [PDF]
Veterinary Pathology, 2020 High-throughput in vitro models lack human-relevant complexity, which undermines their ability to accurately mimic in vivo biologic and pathologic responses. The emergence of microphysiological systems (MPS) presents an opportunity to revolutionize in vitro modeling for both basic biomedical research and applied drug discovery.
Radhakrishna Sura +2 more
openaire +3 more sources
Vascular microphysiological systems to model diseases [PDF]
Cell and Gene Therapy Insights, 2020 Human vascular microphysiological systems (MPS) represent promising three-dimensional in vitro models of normal and diseased vascular tissue. These systems build upon advances in tissue engineering, microfluidics, and stem cell differentiation and replicate key functional units of organs and tissues.
Qiao, Zhang +2 more
openaire +2 more sources
Animal Model Alternatives in Filovirus and Bornavirus Research
Viruses, 2023 The order Mononegavirales contains a variety of highly pathogenic viruses that may infect humans, including the families Filoviridae, Bornaviridae, Paramyxoviridae, and Rhabodoviridae.
Lina Widerspick +3 more
doaj +1 more source
Autologous Human Immunocompetent White Adipose Tissue‐on‐Chip
Advanced Science, 2022 Obesity and associated diseases, such as diabetes, have reached epidemic proportions globally. In this era of “diabesity”, white adipose tissue (WAT) has become a target of high interest for therapeutic strategies.
Julia Rogal +8 more
doaj +1 more source
Microphysiological Systems of Lymphatics and Immune Organs. [PDF]
Adv Healthc MaterAbstract Microphysiological systems (MPS) that incorporate engineered blood vasculatures have enabled new opportunities to study human physiology and disease, offering platforms for drug development, tissue modeling, and regenerative medicine.
Jain I, Singh A, García AJ.
europepmc +3 more sources
3D organ-on-a-chip: The convergence of microphysiological systems and organoids
Frontiers in Cell and Developmental Biology, 2022 Medicine today faces the combined challenge of an increasing number of untreatable diseases and fewer drugs reaching the clinic. While pharmaceutical companies have increased the number of drugs in early development and entering phase I of clinical ...
Leandra S. Baptista +9 more
doaj +1 more source
A Microphysiological System for Studying Nonalcoholic Steatohepatitis [PDF]
Hepatology Communications, 2019 Nonalcoholic steatohepatitis (NASH) is the most severe form of nonalcoholic fatty liver disease (NAFLD), which to date has no approved drug treatments. There is an urgent need for better understanding of the genetic and molecular pathways that underlie NAFLD/NASH, and currently available preclinical models, be they
Kostrzewski, T +7 more
openaire +4 more sources