Human Microphysiological Systems and Organoids as in Vitro Models for Toxicological Studies [PDF]
Frontiers in Public Health, 2018 Organoids and microphysiological systems represent two current approaches to reproduce organ function in vitro. These systems can potentially provide unbiased assays of function which are needed to understand the mechanism of action of environmental ...
George A. Truskey
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Microphysiological systems for solid tumor immunotherapy: opportunities and challenges [PDF]
Microsystems & Nanoengineering, 2023 Immunotherapy remains more effective for hematologic tumors than for solid tumors. One of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate, which limits the cytotoxic capabilities of ...
Sara Abizanda-Campo +7 more
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Complex or not too complex? One size does not fit all in next generation microphysiological systems
iScienceSummary: In the attempt to overcome the increasingly recognized shortcomings of existing in vitro and in vivo models, researchers have started to implement alternative models, including microphysiological systems.
Simone Bersini +4 more
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Bioactive MaterialsSpheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the ...
Yuxuan Zhu +10 more
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Cardiac microphysiological systems in cardiovascular research: Construction paradigms, maturation trajectories, and translational frontiers. [PDF]
Bioeng Transl MedCardiovascular diseases remain the leading cause of global mortality, yet traditional preclinical models fail to accurately capture the physiological and genetic complexity of the human heart, hindering the development of targeted therapies.
Xie R, Zhao H, Lei Y, Wang X.
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Good Systems Network Meeting [PDF]
, 2020 You're viewing a past event from the Good Systems Grand Challenge team at The University of Texas at Austin that contains two presentations from May 19, 2020.Office of the VP for ...
Good Systems
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Stem cell-based vascularization of microphysiological systems [PDF]
, 2021 Microphysiological systems (MPSs) (i.e., tissue or organ chips) exploit microfluidics and 3D cell culture to mimic tissue and organ-level physiology. The advent of human induced pluripotent stem cell (hiPSC) technology has accelerated the use of MPSs to ...
Healy, Kevin E +4 more
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Animal Model Alternatives in Filovirus and Bornavirus Research
Viruses, 2023 The order Mononegavirales contains a variety of highly pathogenic viruses that may infect humans, including the families Filoviridae, Bornaviridae, Paramyxoviridae, and Rhabodoviridae.
Lina Widerspick +3 more
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Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration [PDF]
, 2015 Our goal in developing Microphysiological Systems (MPS) technology is to provide an improved approach for more predictive preclinical drug discovery via a highly integrated experimental/computational paradigm.
Griffith, Linda G +10 more
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3D organ-on-a-chip: The convergence of microphysiological systems and organoids
Frontiers in Cell and Developmental Biology, 2022 Medicine today faces the combined challenge of an increasing number of untreatable diseases and fewer drugs reaching the clinic. While pharmaceutical companies have increased the number of drugs in early development and entering phase I of clinical ...
Leandra S. Baptista +9 more
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