Results 11 to 20 of about 4,082 (188)

Strategies to control cellular spatial organization in microphysiological systems [PDF]

Microsystems & Nanoengineering
Spatial organization is fundamental to tissue physiology, as it governs how cells migrate, grow, differentiate, and interact within their native environments.
Hung Dong Truong, Zhixing Ge, Elgene Chng, Y-Van Tran, Yusheng Zhang, Chwee Teck Lim   +5 more
doaj   +2 more sources

Microphysiological systems: What it takes for community adoption

Experimental Biology and Medicine, 2021
Microphysiological systems (MPS) are promising in vitro tools which could substantially improve the drug development process, particularly for underserved patient populations such as those with rare diseases, neural disorders, and diseases impacting pediatric populations.
Lucie Low, Passley Hargrove-Grimes, Danilo Tagle   +2 more
exaly   +3 more sources

Pillar arrays as tunable interfacial barriers for microphysiological systems [PDF]

Communications Engineering
We report on the design and fabrication of a circular pillar array as an interfacial barrier for microfluidic microphysiological systems (MPS). Traditional barrier interfaces, such as porous membranes and microchannel arrays, present limitations due to ...
Ishan Goswami, Yongdeok Kim, Gabriel Neiman, Brian Siemons, Jazmin I. Velazquez, Kerem Yazgan, Tammy Ng, Sudipta Ashe, Kevin E. Healy   +8 more
doaj   +2 more sources

Microphysiological Systems for Neurodegenerative Diseases in Central Nervous System [PDF]

Micromachines, 2020
Neurodegenerative diseases are among the most severe problems in aging societies. Various conventional experimental models, including 2D and animal models, have been used to investigate the pathogenesis of (and therapeutic mechanisms for ...
Mihyeon Bae, Hee-Gyeong Yi, Jinah Jang, Dong-Woo Cho   +3 more
doaj   +4 more sources

Modelling the innate immune system in microphysiological systems.

Lab Chip
Integration of an immune component moves the field closer to a physiologically relevant human-on-a-chip.
Rupar MJ, Hanson H, Rogers S, Botlick B, Trimmer S, Hickman JJ.   +5 more
europepmc   +3 more sources

Microphysiological systems for human aging research. [PDF]

Aging Cell
AbstractRecent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip (OoC), enable the recapitulation of more complex organ and tissue functions on a smaller scale in vitro. MPS therefore provide the potential to better understand human diseases and physiology.
Park S, Laskow TC, Chen J, Guha P, Dawn B, Kim DH.   +5 more
europepmc   +3 more sources

Microphysiological systems as models for immunologically ‘cold’ tumors [PDF]

Frontiers in Cell and Developmental Biology
The tumor microenvironment (TME) is a diverse milieu of cells including cancerous and non-cancerous cells such as fibroblasts, pericytes, endothelial cells and immune cells.
Daniela Gaebler, Stephanie J. Hachey, Christopher C. W. Hughes, Christopher C. W. Hughes   +3 more
doaj   +2 more sources

Training the Next Generation of Researchers in the Organ-on-Chip Field

Education Sciences, 2023
Organ-on-chip (OoC) technology bridges the principles of biology and engineering to create a new generation of in vitro models and involves highly interdisciplinary collaboration across STEM disciplines.
Alessia Moruzzi, Tanvi Shroff, Silke Keller, Peter Loskill, Madalena Cipriano   +4 more
doaj   +1 more source

Microphysiological Systems: A Pathologist’s Perspective [PDF]

Veterinary Pathology, 2020
High-throughput in vitro models lack human-relevant complexity, which undermines their ability to accurately mimic in vivo biologic and pathologic responses. The emergence of microphysiological systems (MPS) presents an opportunity to revolutionize in vitro modeling for both basic biomedical research and applied drug discovery.
Radhakrishna Sura, Terry Van Vleet, Brian R. Berridge   +2 more
openaire   +3 more sources

Vascular microphysiological systems to model diseases [PDF]

Cell and Gene Therapy Insights, 2020
Human vascular microphysiological systems (MPS) represent promising three-dimensional in vitro models of normal and diseased vascular tissue. These systems build upon advances in tissue engineering, microfluidics, and stem cell differentiation and replicate key functional units of organs and tissues.
Qiao, Zhang, Xu, Zhang, George A, Truskey   +2 more
openaire   +2 more sources