Results 21 to 30 of about 91,588,802 (303)

3D Inkjet-Bioprinted Lung-on-a-Chip [PDF]

, 2023
There is an urgent need for physiologically relevant and customizable biochip models of human lung tissue to provide a niche for lung disease modeling and drug efficacy.
Dayoon Kang, Taejeong Kwak (15334091), Hwa-Rim Lee, Wookyeom Kim (15334082), Sungjune Jung (3236640), Wookyeom Kim, Yunji Lee, Hwa-Rim Lee (9072215), Taejeong Kwak, Sungjune Jung, Yunji Lee (15334085), Dayoon Kang (15334088)   +11 more
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A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents [PDF]

, 2022
S.2688-2699Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied
Drewell, Christopher, Sambo, Naomia Sisoli, Thomas, Alexander, Lauster, Roland, Lorenz, Alexandra K., Lindner, Marcus, Maschmeyer, Ilka, Ramme, Anja P., Bauer, Sophie, Marx, Uwe, Schimek, Katharina, Hübner, Juliane, Hasenberg, Tobias, Sonntag, Frank   +13 more
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WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue [PDF]

, 2022
S.1645-1654Organ-on-a-chip systems possess a promising future as drug screening assays and as testbeds for disease modeling in the context of both single-organ systems and multi-organ-chips.
Zushin, P.J.H., Healy, K.E., Stahl, A., Reese, W.M., Loskill, P., Lee-Montiel, F.T., Jeeawoody, S., Sezhian, T., Tharp, K.M.   +8 more
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A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture [PDF]

, 2022
S.3538-3547Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, to accurately predict drug toxicity.
Lauster, R., Tonevitsky, A.G., Sakharov, D.A., Süßbier, U., Trushkin, E.V., Sonntag, F., Frädrich, C., Brincker, S., Busek, M., Wagner, I., Marx, U., Materne, E.-M.   +11 more
core   +1 more source

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

Frontiers in Bioengineering and Biotechnology, 2023
Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is
Cristian F. Rodríguez, Valentina Andrade-Pérez, María Camila Vargas, Andrés Mantilla-Orozco, Johann F. Osma, Luis H. Reyes, Juan C. Cruz   +6 more
doaj   +1 more source

High-resolution and multi-range particle separation by microscopic vibration in an optofluidic chip [PDF]

, 2017
An optofluidic chip is demonstrated in experiments for high-resolution and multi-range particle separation through the optically-induced microscopic vibration effect, where nanoparticles are trapped in loosely overdamped optical potential wells created ...
Zhang, Jing Bo, Liedberg, B., Liedberg, Bo, P. H. Yap, Y. Zhang, Yap, P. H., Zhang, Yi, Xiong, S., Zhang, Y., Chen, T. N., Y. L. Hao, Chin, Lip Ket, Chin, L. K., S. Xiong, Shi, Yu Zhi, Ser, Wee, Y. Yang, W. Ser, Liu, A. Q., J. B. Zhang, Xiong, Sha, Hao, Yi Long, J. H. Wu, Hao, Y. L., Chen, Tian Ning, A. Q. Liu, Y. Z. Shi, Wu, Jiu Hui, Zhang, J. B., B. Liedberg, Yang, Z. C., Yang, Y., Wu, J. H., Ser, W., Yang, Zhen Chuan, Yap, Peng Huat, Shi, Y. Z., Liu, Ai Qun, T. N. Chen, Z. C. Yang, L. K. Chin, Yang, Yi   +41 more
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Organ-on-a-chip Technology in Urology

Креативная хирургия и онкология, 2023
Organs-on-chips (OOC) refer to microfluidic devices used to create biomimetic systems of physiological organs. The system contains engineered or natural miniature tissues grown inside microfluidic chips.
A. G. Vardikian, S. V. Piatnitskaia, V. A. Solntsev, B. I. Shamsov, V. N. Pavlov   +4 more
doaj   +1 more source

Polylactic acid, a sustainable, biocompatible, transparent substrate material for Organ-On-Chip, and Microfluidic applications [PDF]

, 2019
Organ-on-chips are miniaturised devices aiming at replacing animal models for drug discovery, toxicology and studies of complex biological phenomena. The field of Organ-On-Chip has grown exponentially, and has led to the formation of companies providing ...
Arianna Mencatti, Alfredo E. Ongaro, Lina Ghibelli, Vanessa Mancini, Vicki Stone, Maïwenn Kersaudy-Kerhoas, MaÃwenn Kersaudy-Kerhoas, Virginia Pensabene, Allende Miguelez Crespo, Krystian L. Wlodarczyk, Duncan P. Hand, Nicola Howarth, Davide Di Giuseppe, Vincenzo La Carrubba, Ali Kermanizadeh, Eugenio Martinelli   +15 more
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From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC) [PDF]

, 2020
We present a portable, battery-operated and application-specific lab-on-a-chip (ASLOC) system that can be easily configured for a wide range of lab-on-a-chip applications. It is based on multiplexed electrical current detection that serves as the sensing
Campos, C. D. M., Manz, A., Soon, J. B. W., Neužil, P., Reboud, J., Wong, C. C.   +5 more
core   +1 more source

A guide to the organ-on-a-chip

Nature Reviews Methods Primers, 2022
Organs-on-chips (OoCs) are systems containing engineered or natural miniature tissues grown inside microfluidic chips. To better mimic human physiology, the chips are designed to control cell microenvironments and maintain tissue-specific functions.
Chak Ming Leung, Pim de Haan, Kacey Ronaldson-Bouchard, Ge-Ah Kim, Jihoon Ko, Hoon Suk Rho, Zhu Chen, Pamela Habibovic, Noo Li Jeon, Shuichi Takayama, Michael L. Shuler, Gordana Vunjak-Novakovic, Olivier Frey, Elisabeth Verpoorte, Yi-Chin Toh   +14 more
openaire   +3 more sources