Results 21 to 30 of about 127,842,725 (298)
Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices
Frontiers in Bioengineering and Biotechnology, 2023 Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is
Cristian F. Rodríguez +6 more
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Toxicology Research and Application, 2017 In the last few years, considerable attention has been given to in vitro models in an attempt to reduce the use of animals and to decrease the rate of preclinical failure associated with the development of new drugs. Simple two-dimensional cultures grown in a dish are now frequently replaced by organotypic cultures with three-dimensional (3-D ...
David Bovard +4 more
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Organ-on-a-chip Technology in Urology
Креативная хирургия и онкология, 2023 Organs-on-chips (OOC) refer to microfluidic devices used to create biomimetic systems of physiological organs. The system contains engineered or natural miniature tissues grown inside microfluidic chips.
A. G. Vardikian +4 more
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, 2022 S.1866-1885Membranes play a crucial role in many microfluidic systems, enabling versatile applications in highly diverse research fields. However, the tight and robust integration of membranes into microfluidic systems requires complex fabrication ...
Schneider, S. +3 more
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Design and engineering of organ-on-a-chip
Biomedical Engineering Letters, 2023 Organ-on-a-chip (OOC) is an emerging interdisciplinary technology that reconstitutes the structure, function, and physiology of human tissues as an alternative to conventional preclinical models for drug screening. Over the last decade, substantial progress has been made in mimicking tissue- and organ-level functions on chips through technical advances
Sujin Cho, Sumi Lee, Song Ih Ahn
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Aggregate, 2023 Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more realistically compared to many animal models and conventional two‐dimensional cell cultures.
Sajjad Rahmani Dabbagh +5 more
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Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing
Micromachines, 2021 Tissue chips (TCs) and microphysiological systems (MPSs) that incorporate human cells are novel platforms to model disease and screen drugs and provide an alternative to traditional animal studies.
Leslie Donoghue +3 more
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Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery
Pharmaceutics, 2023 Drug discovery is an expensive, long, and complex process, usually with a high degree of uncertainty. In order to improve the efficiency of drug development, effective methods are demanded to screen lead molecules and eliminate toxic compounds in the ...
Jingyu Fu, Hailong Qiu, Cherie S. Tan
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Organ-on-a-chip technology for nanoparticle research [PDF]
Nano Convergence, 2021 AbstractThe last two decades have witnessed explosive growth in the field of nanoengineering and nanomedicine. In particular, engineered nanoparticles have garnered great attention due to their potential to enable new capabilities such as controlled and targeted drug delivery for treatment of various diseases.
Shawn Kang +2 more
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Microfluidic-Chip-Integrated Biosensors for Lung Disease Models
Biosensors, 2021 Lung diseases (e.g., infection, asthma, cancer, and pulmonary fibrosis) represent serious threats to human health all over the world. Conventional two-dimensional (2D) cell models and animal models cannot mimic the human-specific properties of the lungs.
Shuang Ding, Haijun Zhang, Xuemei Wang
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