Organoids, organs-on-chips and other systems, and microbiota [PDF]
, 2017 The human gut microbiome is considered an organ in its entirety and has been the subject of extensive research due to its role in physiology, metabolism, digestion, and immune regulation.
Evans, Samantha +2 more
core +2 more sources
Hemostasis-On-a-Chip: Impedance Spectroscopy Meets Microfluidics for Hemostasis Evaluation
Micromachines, 2019 In the case of vascular injury, a complex process (of clotting) starts, involving mainly platelets and coagulation factors. This process in healthy humans is known as hemostasis, but when it is deregulated (thrombosis), it can be the cause of important ...
Shadi Karimi +4 more
doaj +1 more source
3D Immunocompetent Organ‐on‐a‐Chip Models
Small Methods, 2020 AbstractIn recent years, engineering of various human tissues in microphysiologically relevant platforms, known as organs‐on‐chips (OOCs), are explored to establish in vitro tissue models that recapitulate the microenvironments found in native organs and tissues.
Sushila Maharjan +2 more
openaire +3 more sources
Towards establishing human body-on-a-chip systems
Stem Cell Research & Therapy, 2022 Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically ...
Zhong Alan Li, Rocky S. Tuan
doaj +1 more source
Lung on a Chip Development from Off-Stoichiometry Thiol–Ene Polymer
Micromachines, 2021 Current in vitro models have significant limitations for new respiratory disease research and rapid drug repurposing. Lung on a chip (LOAC) technology offers a potential solution to these problems.
Roberts Rimsa +8 more
doaj +1 more source
One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology [PDF]
Although various types of organs-on-chips have been introduced recently as tools for drug discovery, the current studies are limited in terms of fabrication methods.
Cho, DW, Lee, H
core +1 more source
Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction [PDF]
, 2016 Microfluidic organ-on-a-chip technology aims to replace animal toxicity testing, but thus far has demonstrated few advantages over traditional methods.
Bavli, D +8 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor [PDF]
, 2015 The blood-brain barrier (BBB) is a critical structure that serves as the gatekeeper between the central nervous system and the rest of the body. It is the responsibility of the BBB to facilitate the entry of required nutrients into the brain and to ...
Aaron B. Bowman +21 more
core +1 more source