Multistep Fluidic Control Network toward the Automated Generation of Organ-on-a-Chip [PDF]
, 2019 Organ-on-a-chip, which mimics physiological functions of organs, is a potential tool for drug development and precision medicine. This chip, accompanied by a suitable culture environment and appropriate culture procedure, allows cells to form functional ...
Jen-Huang Huang +5 more
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Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)
Frontiers in Cell and Developmental Biology, 2021 Identification and approval of new drugs for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on in vitro experiments and animal models of human diseases.
Mridu Malik +6 more
doaj +1 more source
Towards the joint on a chip: double layered directly interfaced tissues to mimic the Osteoarthritic cartilage-subchondral interface [PDF]
, 2020 Osteoarthritis (OA) is the most diffused musculoskeletal disease and a worldwide cause of pain and disability. Although OA’s most evidently affected tissue is cartilage (AC), pathological changes regard the whole joint.
Andrea Mainardi +5 more
core
Fusing spheroids to aligned μ-tissues in a heart-on-chip featuring oxygen sensing and electrical pacing capabilities [PDF]
, 2022 Over the last decade, Organ-on-Chip (OoC) emerged as a promising technology for advanced in vitro models, recapitulating key physiological cues. OoC approaches tailored for cardiac tissue engineering resulted in a variety of platforms, some of which ...
Mayr, Torsten +10 more
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Fast electrically assisted regeneration of on-chip SERS substrates [PDF]
, 2022 S.2923-2927A microfluidic chip approach utilising integrated electrically connected stationary SERS targets based on inkjet-printed silver nanoparticles is presented.
Belder, Detlev +7 more
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Bioinspired human stomach-on-a-chip with in vivo like function and architecture [PDF]
, 2023 The lack of biomimetic in vitro models capable of reproducing the complex architecture and the dynamic environment of the gastric mucosa, delay the development of diagnostic and therapeutic tools.
Oliveira, Carla; orcid: +5 more
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Colloids and Surfaces B: BiointerfacesTraditional drug development methods have relied on 2D cell cultures and animal models, which have not been able to adequately represent human biology. Due to genetic and physiological variances in human biology, animal models cannot yield accurate results, whereas 2D cell cultures are insufficient in simulating tissue architecture and cell-to-cell ...
Aarif Ali +6 more
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Recapitulating Solid Stress on Tumor on a Chip for Nanomedicine Diffusive Transport Prediction
Advanced NanoBiomed Research, 2023 The characteristic mechanical forces at play within tumors include the abnormal solid and fluid stresses. These, together with the increased extracellular matrix (ECM) stiffness, are the major transport barriers affecting the nanomedicine delivery to ...
Alberto Martín-Asensio +8 more
doaj +1 more source
3D printed nervous system on a chip [PDF]
, 2015 Bioinspired organ-level in vitro platforms are emerging as effective technologies for fundamental research, drug discovery, and personalized healthcare. In particular, models for nervous system research are especially important, due to the complexity of ...
Meng, Fanben +6 more
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PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications [PDF]
, 2020 Polydimethylsiloxane (PDMS) is among the most widely used materials for organ-on-chip systems. Despite itsmultiple beneficial characteristics from an engineering point of view, there is a concern about the effect of PDMSon the cells cultured in such ...
Carter, Sarah-Sophia, +15 more
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