Results 51 to 60 of about 91,588,802 (303)
Evaluation of Human Performance Aiding Live Synthetically Engineered Bacteria in a Gut-on-a-Chip [PDF]
, 2022 Synbiotics are a new class of live therapeutics employing engineered genetic circuits. The rapid adoption of genetic editing tools has catalyzed the expansion of possible synbiotics, exceeding traditional testing paradigms in terms of both throughput and
Latha Narayanan (2376148) +11 more
core +1 more source
Supplementary material. Autologous iPSC-derived four-organ-chip [PDF]
, 2019 Supplementary material. Autologous iPSC-derived four-organ-chipMicrophysiological systems play a pivotal role in progressing towards a global paradigm shift in drug development.
Lin, Grace (7363457) +17 more
core +1 more source
Hemostasis-On-a-Chip: Impedance Spectroscopy Meets Microfluidics for Hemostasis Evaluation
Micromachines, 2019 In the case of vascular injury, a complex process (of clotting) starts, involving mainly platelets and coagulation factors. This process in healthy humans is known as hemostasis, but when it is deregulated (thrombosis), it can be the cause of important ...
Shadi Karimi +4 more
doaj +1 more source
Towards establishing human body-on-a-chip systems
Stem Cell Research & Therapy, 2022 Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically ...
Zhong Alan Li, Rocky S. Tuan
doaj +1 more source
Lung on a Chip Development from Off-Stoichiometry Thiol–Ene Polymer
Micromachines, 2021 Current in vitro models have significant limitations for new respiratory disease research and rapid drug repurposing. Lung on a chip (LOAC) technology offers a potential solution to these problems.
Roberts Rimsa +8 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Breakthroughs and Applications of Organ-on-a-Chip Technology
Cells, 2022 Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous advantages of OOAC over conventional systems make it highly popular.
Mufeeda C. Koyilot +14 more
openaire +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Graphical Abstract. Autologous iPSC-derived four-organ-chip [PDF]
, 2019 Microphysiological systems play a pivotal role in progressing towards a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents.
Lin, Grace (7363457) +17 more
core +1 more source
PLGA Nanofiber/PDMS Microporous Composite Membrane-Sandwiched Microchip for Drug Testing
Micromachines, 2020 Lung-on-a-chip devices could provide new strategies for a biomimetic lung cell microenvironment and construction of lung disease models in vitro, and are expected to greatly promote the development of drug evaluation, toxicological detection, and disease
Wei Li +6 more
doaj +1 more source